The association of total sialic acid and malondialdehyde levels with metabolic and anthropometric variables in obesity

Serum sialic acid levels are abnormally high in pathological states that exhibit tissue destruction, tissue proliferation or inflammation. We measured total serum sialic acid levels in 139 women and 125 men. Subjects were divided into quartiles according to their body mass index (BMI): Q1 (18-24.9 kg/m(2)), Q2 (25 -29.9 kg/m(2)), Q3 (30 -39.9 kg/m(2)) and Q4 (> 40 kg/m(2)). The patients in Q1 constituted the control group. Serum sialic acid levels of subjects in Q2, Q3 and Q4 were signifi cantly higher than those in Q1. Higher BMI quartiles also were associated with higher levels of serum glucose, insulin, total cholesterol, LDL-cholesterol, triglycerides, high-sensitivity C-reactive protein, malondialdehyde levels, waist circumference, blood pressure and homeostasis model assessment of insulin resistance in both women and men. Lower BMI quartiles were associated with higher levels of serum HDL-cholesterol levels in both women and men. We found positive associations among serum sialic acid levels, BMI and oxidative stress. Serum sialic acid also is related to some conventional cardiovascular risk factors including elevated lipid profile, increased blood pressure, increased serum glucose and insulin levels, and insulin resistance in obese people.

Yazar Yerlikaya, F. H.
Toker, A.
Cicekler, H.
Aribas, A.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3459
Tek Biçim Adres 10.3109/10520295.2014.937744
Konu Başlıkları body mass index
cardiovascular risk
obesity
oxidative stress
sialic acid
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı BIOTECHNIC & HISTOCHEMISTRY
Dergi Cilt Bilgisi 90
Dergi Sayısı 1
Sayfalar 31 - 37
Yayın Yılı 2015
Eser Adı
[dc.title]
The association of total sialic acid and malondialdehyde levels with metabolic and anthropometric variables in obesity
Yazar
[dc.contributor.author]
Yerlikaya, F. H.
Yazar
[dc.contributor.author]
Toker, A.
Yazar
[dc.contributor.author]
Cicekler, H.
Yazar
[dc.contributor.author]
Aribas, A.
Yayın Yılı
[dc.date.issued]
2015
Yayıncı
[dc.publisher]
TAYLOR & FRANCIS LTD
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Serum sialic acid levels are abnormally high in pathological states that exhibit tissue destruction, tissue proliferation or inflammation. We measured total serum sialic acid levels in 139 women and 125 men. Subjects were divided into quartiles according to their body mass index (BMI): Q1 (18-24.9 kg/m(2)), Q2 (25 -29.9 kg/m(2)), Q3 (30 -39.9 kg/m(2)) and Q4 (> 40 kg/m(2)). The patients in Q1 constituted the control group. Serum sialic acid levels of subjects in Q2, Q3 and Q4 were signifi cantly higher than those in Q1. Higher BMI quartiles also were associated with higher levels of serum glucose, insulin, total cholesterol, LDL-cholesterol, triglycerides, high-sensitivity C-reactive protein, malondialdehyde levels, waist circumference, blood pressure and homeostasis model assessment of insulin resistance in both women and men. Lower BMI quartiles were associated with higher levels of serum HDL-cholesterol levels in both women and men. We found positive associations among serum sialic acid levels, BMI and oxidative stress. Serum sialic acid also is related to some conventional cardiovascular risk factors including elevated lipid profile, increased blood pressure, increased serum glucose and insulin levels, and insulin resistance in obese people.
Açıklama
[dc.description]
WOS: 000351942200005
Açıklama
[dc.description]
PubMed: 25151992
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
body mass index
Konu Başlıkları
[dc.subject]
cardiovascular risk
Konu Başlıkları
[dc.subject]
obesity
Konu Başlıkları
[dc.subject]
oxidative stress
Konu Başlıkları
[dc.subject]
sialic acid
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1052-0295
ISSN
[dc.identifier.issn]
1473-7760
İlk Sayfa Sayısı
[dc.identifier.startpage]
31
Son Sayfa Sayısı
[dc.identifier.endpage]
37
Dergi Adı
[dc.relation.journal]
BIOTECHNIC & HISTOCHEMISTRY
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
90
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.3109/10520295.2014.937744
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3459
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
11
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
13 Aralık 2023 03:02
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Tıklayınız
levels sialic kg/m(2)) insulin quartiles higher associated pressure resistance glucose increased tissue malondialdehyde protein including C-reactive high-sensitivity elevated triglycerides LDL-cholesterol cholesterol profile people factors circumference related oxidative stress HDL-cholesterol associations conventional assessment cardiovascular homeostasis positive
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