Myocardial functional and textural findings of the right and left ventricles and their association with cellular adhesion molecules in Behcet's disease

Aim: This study was designed to assess whether ultrasonic reflectivity, evaluated by integrated backscatter analysis was associated with the severity of inflammation and diastolic dysfunction of the left (LV) and right ventricles (RV) in Behcet's disease (BD). Methods: The study consisted of 20 patients with BD and 18 healthy controls. The expression of CD11b and CD63 on the surface of granulocytes and monocytes were measured by flow cytometry. RV and LV diastolic functions were assessed by tricuspid and mitral annular tissue Doppler recordings, respectively. Backscatter cyclic variation (CV) and maximal intensity (IB) were measured in RV lateral wall, interventricular septum, and posterior LV wall from parasternal long-axis view, apex from apical four-chamber view, anterior, inferior, and lateral LV walls from parasternal short axis view. Results: The mean fluorescence intensity (MFI) of CD11b on granulocytes and CD63 on monocytes in BD patients was higher than those of controls. Patients with BD had smaller mitral and tricuspid annular early diastolic wave velocities and early/late diastolic wave velocity ratios (EIA) than controls. MFI of CD11b and CD63 was inversely correlated with tricuspid and mitral annular E/A in BD patients. CV of RV and global CV of LV were found to be diminished in BD patients than controls. CV of RV and global CV of LV showed a direct correlation with tricuspid and mitral annular EIA ratio, respectively. Conclusion: There is an association between the levels of cellular adhesion molecules, deterioration of diastolic function, and altered myocardial ultrasonic reflectivity in BD.

Yazar Yildirim, Nesligul
Tekin, Nilgun Solak
Tekin, Ishak Ozel
Dogan, Sait
Aydin, Mustafa
Gursurer, Metin
Dursun, Aydin
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2970
Tek Biçim Adres 10.1111/j.1540-8175.2007.00475.x
Konu Başlıkları Behcet's disease
inflammation
integrated backscatter
diastolic function
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
Dergi Cilt Bilgisi 24
Dergi Sayısı 7
Sayfalar 702 - 711
Yayın Yılı 2007
Eser Adı
[dc.title]
Myocardial functional and textural findings of the right and left ventricles and their association with cellular adhesion molecules in Behcet's disease
Yazar
[dc.contributor.author]
Yildirim, Nesligul
Yazar
[dc.contributor.author]
Tekin, Nilgun Solak
Yazar
[dc.contributor.author]
Tekin, Ishak Ozel
Yazar
[dc.contributor.author]
Dogan, Sait
Yazar
[dc.contributor.author]
Aydin, Mustafa
Yazar
[dc.contributor.author]
Gursurer, Metin
Yazar
[dc.contributor.author]
Dursun, Aydin
Yayın Yılı
[dc.date.issued]
2007
Yayıncı
[dc.publisher]
WILEY
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Aim: This study was designed to assess whether ultrasonic reflectivity, evaluated by integrated backscatter analysis was associated with the severity of inflammation and diastolic dysfunction of the left (LV) and right ventricles (RV) in Behcet's disease (BD). Methods: The study consisted of 20 patients with BD and 18 healthy controls. The expression of CD11b and CD63 on the surface of granulocytes and monocytes were measured by flow cytometry. RV and LV diastolic functions were assessed by tricuspid and mitral annular tissue Doppler recordings, respectively. Backscatter cyclic variation (CV) and maximal intensity (IB) were measured in RV lateral wall, interventricular septum, and posterior LV wall from parasternal long-axis view, apex from apical four-chamber view, anterior, inferior, and lateral LV walls from parasternal short axis view. Results: The mean fluorescence intensity (MFI) of CD11b on granulocytes and CD63 on monocytes in BD patients was higher than those of controls. Patients with BD had smaller mitral and tricuspid annular early diastolic wave velocities and early/late diastolic wave velocity ratios (EIA) than controls. MFI of CD11b and CD63 was inversely correlated with tricuspid and mitral annular E/A in BD patients. CV of RV and global CV of LV were found to be diminished in BD patients than controls. CV of RV and global CV of LV showed a direct correlation with tricuspid and mitral annular EIA ratio, respectively. Conclusion: There is an association between the levels of cellular adhesion molecules, deterioration of diastolic function, and altered myocardial ultrasonic reflectivity in BD.
Açıklama
[dc.description]
WOS: 000248504600007
Açıklama
[dc.description]
PubMed: 17651099
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Behcet's disease
Konu Başlıkları
[dc.subject]
inflammation
Konu Başlıkları
[dc.subject]
integrated backscatter
Konu Başlıkları
[dc.subject]
diastolic function
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0742-2822
ISSN
[dc.identifier.issn]
1540-8175
İlk Sayfa Sayısı
[dc.identifier.startpage]
702
Son Sayfa Sayısı
[dc.identifier.endpage]
711
Dergi Adı
[dc.relation.journal]
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
Dergi Sayısı
[dc.identifier.issue]
7
Dergi Cilt Bilgisi
[dc.identifier.volume]
24
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1111/j.1540-8175.2007.00475.x
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2970
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
10
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 14:44
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diastolic tricuspid mitral annular patients controls granulocytes global respectively ultrasonic monocytes reflectivity measured intensity lateral parasternal velocity ratios higher Results early/late velocities smaller fluorescence Patients myocardial altered function deterioration molecules adhesion cellular levels between association
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