A case report: Liver metastasis of carcinoid tumor with gallbladder adenocarcinoma [Safra kesesi adenokarsinomu ile birlikte karacigerde karsinoid tümör metastazi: Olgu sunumu]

Majority of hepatic carcinoid tumors are metastatic, and frequently the origin of the tumor is gastrointestinal system. It is occasionally regarded as primary, after long term of clinical follow up or without any incidental finding during otopsy for focus of tumor. For carcinoid tumor cases, high frequency of secondary non-carcinoid neoplasm sourced from gastrointestinal system especially colon adenocarcinoma is well known. Though, carcinoid tumor accompany with gallbladder carcinoma is extremely rare. 73 years old woman applied to the emergency service with abdominal pain. Abdominal ultrasonography and tomography revealed multiple metastasis concordant with abdominal mass and after that, with the preliminary diagnosis 'acute cholecystitidis' and 'hepatic metastatic mass lesion' the patient underwent cholecystectomy and hepatic local mass exicision. A brown lesion in 1 cm diameter at the fundus is observed during macroscopic examination. Microscopic examination of this lesion showed adenocarcinoma infiltration up to serosa and focal reaction with musicarmine within the tumor cells. Immunohistochemically, there is positive reaction with pancytokeratin (AE1/AE3) with no chromogranin-A expression. Gross examination of hepatic mass lesion is solid with smooth surface and microscopic examination revealed tumor, composed of cells exhibiting organoid pattern, which has centrally located vesicular nucleus and large granular eosinophilic cytoplasm, and adjacent to normal liver tissue. Immunohistochemically, it is determined that there is weak reaction with pancytokeratin (AE1/AE3) within tumor cells and strong and diffuse expression of chromogranin-A and synaptophysin. With these findings, it is concluded that the hepatic mass is 'carcinoid tumor'. To rule out the possibility of a metastatic lesion because of its multiple quantity, further investigations are done to determine a primary focus but cannot be found. For the cases of carcinoid tumor, encountered with gallbladder adenocarcinoma, clinical course of the disease depends upon biologic behaviour of adenocarcinoma. Because of rarerity, we report the case.

Dergi Adı Ondokuz Mayis Universitesi Tip Dergisi
Dergi Cilt Bilgisi 25
Dergi Sayısı 1
Sayfalar 30 - 34
Yayın Yılı 2008
Eser Adı
[dc.title]
A case report: Liver metastasis of carcinoid tumor with gallbladder adenocarcinoma [Safra kesesi adenokarsinomu ile birlikte karacigerde karsinoid tümör metastazi: Olgu sunumu]
Yazar
[dc.contributor.author]
Barut F.
Yazar
[dc.contributor.author]
Özdamar Ş.O.
Yazar
[dc.contributor.author]
Kertiş G.
Yazar
[dc.contributor.author]
Bahadir B.
Yazar
[dc.contributor.author]
Cömert M.
Yazar
[dc.contributor.author]
Banu Dogan G.Ü.N.
Yayın Yılı
[dc.date.issued]
2008
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Majority of hepatic carcinoid tumors are metastatic, and frequently the origin of the tumor is gastrointestinal system. It is occasionally regarded as primary, after long term of clinical follow up or without any incidental finding during otopsy for focus of tumor. For carcinoid tumor cases, high frequency of secondary non-carcinoid neoplasm sourced from gastrointestinal system especially colon adenocarcinoma is well known. Though, carcinoid tumor accompany with gallbladder carcinoma is extremely rare. 73 years old woman applied to the emergency service with abdominal pain. Abdominal ultrasonography and tomography revealed multiple metastasis concordant with abdominal mass and after that, with the preliminary diagnosis 'acute cholecystitidis' and 'hepatic metastatic mass lesion' the patient underwent cholecystectomy and hepatic local mass exicision. A brown lesion in 1 cm diameter at the fundus is observed during macroscopic examination. Microscopic examination of this lesion showed adenocarcinoma infiltration up to serosa and focal reaction with musicarmine within the tumor cells. Immunohistochemically, there is positive reaction with pancytokeratin (AE1/AE3) with no chromogranin-A expression. Gross examination of hepatic mass lesion is solid with smooth surface and microscopic examination revealed tumor, composed of cells exhibiting organoid pattern, which has centrally located vesicular nucleus and large granular eosinophilic cytoplasm, and adjacent to normal liver tissue. Immunohistochemically, it is determined that there is weak reaction with pancytokeratin (AE1/AE3) within tumor cells and strong and diffuse expression of chromogranin-A and synaptophysin. With these findings, it is concluded that the hepatic mass is 'carcinoid tumor'. To rule out the possibility of a metastatic lesion because of its multiple quantity, further investigations are done to determine a primary focus but cannot be found. For the cases of carcinoid tumor, encountered with gallbladder adenocarcinoma, clinical course of the disease depends upon biologic behaviour of adenocarcinoma. Because of rarerity, we report the case.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
tur
Konu Başlıkları
[dc.subject]
Carcinoid tumor
Konu Başlıkları
[dc.subject]
Gallbladder adenocarcinoma
Konu Başlıkları
[dc.subject]
Synchrone tumors
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1300-2996
İlk Sayfa Sayısı
[dc.identifier.startpage]
30
Son Sayfa Sayısı
[dc.identifier.endpage]
34
Dergi Adı
[dc.relation.journal]
Ondokuz Mayis Universitesi Tip Dergisi
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
25
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3881
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
22
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 12:28
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Tıklayınız
hepatic carcinoid lesion adenocarcinoma examination reaction metastatic within chromogranin-A gallbladder gastrointestinal system during expression multiple primary (AE1/AE3) abdominal pancytokeratin revealed clinical Immunohistochemically located vesicular nucleus granular centrally Because microscopic report pattern organoid exhibiting composed cytoplasm
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