Reasons for false-negative and false-positive diagnosis in fine needle aspiration cytology of the breast: 286 Cases with cyto-histopathologic correlation [Meme i·nce i·gne aspirasyon sitolojisinde yanliş negatif ve yanliş pozitif tani nedenleri: 286 Olguda sito-histopatolojik korelasyon]

Objective: Fine needle aspiration cytology is the first step in the diagnosing breast lesions. This study evaluated factors causing false-negative and false-positive diagnoses when evaluating breast lesions using this technique. Material and Method: In this study, we retrospectively examined 511 breast diagnoses, based on Fine needle aspiration cytology specimens, made in the Medical School of Zonguldak Karaelmas University, Department of Pathology, between 2002 and 2009. Factors affecting the reliability of fine needle aspiration cytology were evaluated by comparing the cytological and biopsy diagnoses and using the clinical parameters in the diagnosis of breast lesions. Result: In our series, the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of fine needle aspiration cytology were 77%, 99%, 95%, 93%, and 95%, respectively. The false-negative diagnosis rate was 4% and the false-positive diagnosis rate was 1%. Conclusion: Sampling errors and erroneous interpretation of cellular monomorphism are the most important reasons for false-negative diagnosis results in the evaluation of breast lesions with fine needle aspiration cytology. Increased cellularity and reactive cell atypia in benign proliferative breast lesions are the most frequent reasons for false-positive diagnosis.

Yazar Onak Kandemir N.
Bektaş S.
Barut F.
Yurdakan G.
Bahadir B.
Dogan Gün B.
Özdamar Ş.O.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/7326
Tek Biçim Adres 10.5146/tjpath.2010.01029
Konu Başlıkları Breast cancer
Cytology
Fine-needle aspiration
Koleksiyonlar Fakülteler
Tıp Fakültesi
Cerrahi Bilimler Bölümü
Makale Koleksiyonu (Cerrahi Bilimler Bölümü)
Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı Turk Patoloji Dergisi/Turkish Journal of Pathology
Dergi Cilt Bilgisi 26
Dergi Sayısı 3
Sayfalar 230 - 237
Yayın Yılı 2010
Eser Adı
[dc.title]
Reasons for false-negative and false-positive diagnosis in fine needle aspiration cytology of the breast: 286 Cases with cyto-histopathologic correlation [Meme i·nce i·gne aspirasyon sitolojisinde yanliş negatif ve yanliş pozitif tani nedenleri: 286 Olguda sito-histopatolojik korelasyon]
Yazar
[dc.contributor.author]
Onak Kandemir N.
Yazar
[dc.contributor.author]
Bektaş S.
Yazar
[dc.contributor.author]
Barut F.
Yazar
[dc.contributor.author]
Yurdakan G.
Yazar
[dc.contributor.author]
Bahadir B.
Yazar
[dc.contributor.author]
Dogan Gün B.
Yazar
[dc.contributor.author]
Özdamar Ş.O.
Yayın Yılı
[dc.date.issued]
2010
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: Fine needle aspiration cytology is the first step in the diagnosing breast lesions. This study evaluated factors causing false-negative and false-positive diagnoses when evaluating breast lesions using this technique. Material and Method: In this study, we retrospectively examined 511 breast diagnoses, based on Fine needle aspiration cytology specimens, made in the Medical School of Zonguldak Karaelmas University, Department of Pathology, between 2002 and 2009. Factors affecting the reliability of fine needle aspiration cytology were evaluated by comparing the cytological and biopsy diagnoses and using the clinical parameters in the diagnosis of breast lesions. Result: In our series, the sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of fine needle aspiration cytology were 77%, 99%, 95%, 93%, and 95%, respectively. The false-negative diagnosis rate was 4% and the false-positive diagnosis rate was 1%. Conclusion: Sampling errors and erroneous interpretation of cellular monomorphism are the most important reasons for false-negative diagnosis results in the evaluation of breast lesions with fine needle aspiration cytology. Increased cellularity and reactive cell atypia in benign proliferative breast lesions are the most frequent reasons for false-positive diagnosis.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
tur
Konu Başlıkları
[dc.subject]
Breast cancer
Konu Başlıkları
[dc.subject]
Cytology
Konu Başlıkları
[dc.subject]
Fine-needle aspiration
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1018-5615
İlk Sayfa Sayısı
[dc.identifier.startpage]
230
Son Sayfa Sayısı
[dc.identifier.endpage]
237
Dergi Adı
[dc.relation.journal]
Turk Patoloji Dergisi/Turkish Journal of Pathology
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
26
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.5146/tjpath.2010.01029
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7326
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
336
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
11 Haziran 2024 00:38
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Tıklayınız
breast diagnosis needle aspiration cytology lesions diagnoses false-positive false-negative predictive reasons evaluated specificity accuracy positive frequent proliferative benign atypia respectively negative evaluation monomorphism results series important Increased cellularity cellular interpretation erroneous errors Sampling reactive Conclusion
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