Endothelial nitric oxide synthase expression in gestational trophoblastic diseases

Objective: Nitric oxide is thought to play a role in the regulation of trophoblast activity. The aim of this study was to compare endothelial nitric oxide synthase expression in tissue samples taken from gestational trophoblastic diseases and placentas of normal pregnancies. Methods: The expression of endothelial nitric oxide synthase was tested in formalin-fixed, paraffin-embedded tissues from specimens including 8 first trimester placentas, 3 partial hydatidiform moles, 20 complete hydatidiform moles, 2 invasive moles, and 5 choriocarcinomas. The expression of antibody was scored by a semiquantitative scale to define staining intensity. Results: The first trimester placentas showed moderate expression in the villous. Gestational trophoblastic diseases displayed strong to very strong endothelial nitric oxide synthase expression in the syncytiotrophoblast, villous, and proliferating mononuclear trophoblasts. Conclusions: Endothelial nitric oxide synthase expression seems to have a strong correlation with proliferation of trophoblastic cells, in gestational trophoblastic diseases and in normal pregnancy. Copyright © 2010 by IGCS and ESGO.

Dergi Adı International Journal of Gynecological Cancer
Dergi Cilt Bilgisi 20
Dergi Sayısı 3
Sayfalar 337 - 340
Yayın Yılı 2010
Eser Adı
[dc.title]
Endothelial nitric oxide synthase expression in gestational trophoblastic diseases
Yazar
[dc.contributor.author]
Barut A.
Yazar
[dc.contributor.author]
Harma M.
Yazar
[dc.contributor.author]
Arikan I.
Yazar
[dc.contributor.author]
Harma M.I.
Yazar
[dc.contributor.author]
Barut F.
Yayın Yılı
[dc.date.issued]
2010
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: Nitric oxide is thought to play a role in the regulation of trophoblast activity. The aim of this study was to compare endothelial nitric oxide synthase expression in tissue samples taken from gestational trophoblastic diseases and placentas of normal pregnancies. Methods: The expression of endothelial nitric oxide synthase was tested in formalin-fixed, paraffin-embedded tissues from specimens including 8 first trimester placentas, 3 partial hydatidiform moles, 20 complete hydatidiform moles, 2 invasive moles, and 5 choriocarcinomas. The expression of antibody was scored by a semiquantitative scale to define staining intensity. Results: The first trimester placentas showed moderate expression in the villous. Gestational trophoblastic diseases displayed strong to very strong endothelial nitric oxide synthase expression in the syncytiotrophoblast, villous, and proliferating mononuclear trophoblasts. Conclusions: Endothelial nitric oxide synthase expression seems to have a strong correlation with proliferation of trophoblastic cells, in gestational trophoblastic diseases and in normal pregnancy. Copyright © 2010 by IGCS and ESGO.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Nitric oxide synthase
Konu Başlıkları
[dc.subject]
Placenta
Konu Başlıkları
[dc.subject]
Trophoblastic disease
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1048891X
İlk Sayfa Sayısı
[dc.identifier.startpage]
337
Son Sayfa Sayısı
[dc.identifier.endpage]
340
Dergi Adı
[dc.relation.journal]
International Journal of Gynecological Cancer
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
20
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1111/IGC.0b013e3181b7a35e
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5616
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
38
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 21:53
Google Kontrol
Tıklayınız
expression synthase nitric trophoblastic placentas strong endothelial diseases gestational hydatidiform normal villous trimester Conclusions Copyright semiquantitative define staining intensity Results showed moderate Gestational scored displayed pregnancy syncytiotrophoblast proliferating mononuclear proliferation correlation Endothelial trophoblasts Objective antibody
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms