A case of Langerhans Cell Histiocytosis with Multisystemic Involvement in an Adult Patient

Langerhans cell histiocytosis (LCH) is a rare group of idiopathic diseases characterized by abnormal proliferation of bone marrow-derived dendritic cells called histiocytes. It is more common in childhood, but in the literature, some adult cases have been reported. For several reasons, the disease is more familiar to pediatricians than it is to physicians handling adult cases; therefore, the diagnosis of adult cases is often delayed or missed. The clinical course of LCH is variable, ranging from a self-healing solitary bone lesion to a widely disseminated life-threatening disease. The diagnosis of LCH should be based on histologic and immunophenotypic examination of perilesional skin. In this report, we present a case of LCH in a 66-yearold woman with bone, skin, and pituitary gland involvement; this case emphasizes that a patient with LCH should undergo careful multidisciplinary evaluation.

Langerhans cell histiocytosis (LCH) is a rare group of idiopathic diseases characterized by abnormal proliferation of bone marrow-derived dendritic cells called histiocytes. It is more common in childhood, but in the literature, some adult cases have been reported. For several reasons, the disease is more familiar to pediatricians than it is to physicians handling adult cases; therefore, the diagnosis of adult cases is often delayed or missed. The clinical course of LCH is variable, ranging from a self-healing solitary bone lesion to a widely disseminated life-threatening disease. The diagnosis of LCH should be based on histologic and immunophenotypic examination of perilesional skin. In this report, we present a case of LCH in a 66-yearold woman with bone, skin, and pituitary gland involvement; this case emphasizes that a patient with LCH should undergo careful multidisciplinary evaluation.

Dergi Adı Erciyes Medical Journal
Dergi Cilt Bilgisi 38
Dergi Sayısı 2
Sayfalar 78 - 80
Yayın Yılı 2016
Eser Adı
[dc.title]
A case of Langerhans Cell Histiocytosis with Multisystemic Involvement in an Adult Patient
Yazar
[dc.contributor.author]
Demirel, Beril Gülüş
Yazar
[dc.contributor.author]
Tekin, Nilgün Solak
Yazar
[dc.contributor.author]
Barut, Figen
Yazar
[dc.contributor.author]
Aslaner, Müzeyyen
Yazar
[dc.contributor.author]
Koca, Rafet
Yazar
[dc.contributor.author]
Gencer, Duygu
Yayın Yılı
[dc.date.issued]
2016
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Langerhans cell histiocytosis (LCH) is a rare group of idiopathic diseases characterized by abnormal proliferation of bone marrow-derived dendritic cells called histiocytes. It is more common in childhood, but in the literature, some adult cases have been reported. For several reasons, the disease is more familiar to pediatricians than it is to physicians handling adult cases; therefore, the diagnosis of adult cases is often delayed or missed. The clinical course of LCH is variable, ranging from a self-healing solitary bone lesion to a widely disseminated life-threatening disease. The diagnosis of LCH should be based on histologic and immunophenotypic examination of perilesional skin. In this report, we present a case of LCH in a 66-yearold woman with bone, skin, and pituitary gland involvement; this case emphasizes that a patient with LCH should undergo careful multidisciplinary evaluation.
Özet
[dc.description.abstract]
Langerhans cell histiocytosis (LCH) is a rare group of idiopathic diseases characterized by abnormal proliferation of bone marrow-derived dendritic cells called histiocytes. It is more common in childhood, but in the literature, some adult cases have been reported. For several reasons, the disease is more familiar to pediatricians than it is to physicians handling adult cases; therefore, the diagnosis of adult cases is often delayed or missed. The clinical course of LCH is variable, ranging from a self-healing solitary bone lesion to a widely disseminated life-threatening disease. The diagnosis of LCH should be based on histologic and immunophenotypic examination of perilesional skin. In this report, we present a case of LCH in a 66-yearold woman with bone, skin, and pituitary gland involvement; this case emphasizes that a patient with LCH should undergo careful multidisciplinary evaluation.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Genel ve Dahili Tıp
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
2149-2247
İlk Sayfa Sayısı
[dc.identifier.startpage]
78
Son Sayfa Sayısı
[dc.identifier.endpage]
80
Dergi Adı
[dc.relation.journal]
Erciyes Medical Journal
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
38
Tek Biçim Adres
[dc.identifier.uri]
http://www.trdizin.gov.tr/publication/paper/detail/TWpBMU1ETTRPQT09
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/123
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
27
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 08:51
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diagnosis should disease solitary life-threatening undergo disseminated widely lesion self-healing ranging variable careful course patient report histologic emphasizes involvement immunophenotypic examination pituitary perilesional 66-yearold present clinical therefore missed abnormal histiocytes called dendritic marrow-derived proliferation childhood
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