Ischemia modified albumin increase indicating cardiac damage after experimental subarachnoid hemorrhage

Background: Cardiac complications are often developed after subarachnoid hemorrhage (SAH) and may cause sudden death of the patient. There are reports in the literature addressing ischemia modified albumin (IMA) as an early and useful marker in the diagnosis of ischemic heart events. The aim of this study is to evaluate serum IMA by using the albumin cobalt binding (ACB) test in the first, second, and seventh days of experimental SAH in rats.Twenty-eight Wistar albino rats were divided into four groups each consisting of seven animals. These were classified as control group, 1st, 2nd and 7th day SAH groups. SAH was done by transclival basilar artery puncture. Blood samples were collected under anesthesia from the left ventricles of the heart using the cardiac puncture method for IMA measurement. Histopathological examinations were performed on the heart and lung tissues. Albumin with by colorimetric, creatine kinase (CK), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) were determined on an automatic analyser using the enzymatic method. IMA using by ACB test was detected with spectrophotometer.Results: Serum IMA (p = 0.044) in seventh day of SAH were higher compared to the control group. Total injury scores of heart and lung tissue, also myocytolysis at day 7 were significantly higher than control group (p = 0.001, p = 0.001, p = 0.001), day 1 (p = 0.001, p = 0.001, p = 0.001) and day 2 (p = 0.001, p = 0.007, p = 0.001). A positive correlation between IMA - myocytolysis (r = 0.48, p = 0.008), and between IMA - heart tissue total injury score (r = 0.41, p = 0.029) was found.Conclusion: The results revealed that increased serum IMA may be related to myocardial stress after SAH. © 2014 Açi{dotless}kgöz et al.; licensee BioMed Central Ltd.

Dergi Adı BMC Neuroscience
Dergi Cilt Bilgisi 15
Sayfalar -
Yayın Yılı 2014
Eser Adı
[dc.title]
Ischemia modified albumin increase indicating cardiac damage after experimental subarachnoid hemorrhage
Yazar
[dc.contributor.author]
Açikgöz S.
Yazar
[dc.contributor.author]
Edebali N.
Yazar
[dc.contributor.author]
Barut F.
Yazar
[dc.contributor.author]
Can M.
Yazar
[dc.contributor.author]
Tekin T.T.
Yazar
[dc.contributor.author]
Büyükuysal T.
Yazar
[dc.contributor.author]
Açikgöz B.
Yayın Yılı
[dc.date.issued]
2014
Yayıncı
[dc.publisher]
BioMed Central Ltd.
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: Cardiac complications are often developed after subarachnoid hemorrhage (SAH) and may cause sudden death of the patient. There are reports in the literature addressing ischemia modified albumin (IMA) as an early and useful marker in the diagnosis of ischemic heart events. The aim of this study is to evaluate serum IMA by using the albumin cobalt binding (ACB) test in the first, second, and seventh days of experimental SAH in rats.Twenty-eight Wistar albino rats were divided into four groups each consisting of seven animals. These were classified as control group, 1st, 2nd and 7th day SAH groups. SAH was done by transclival basilar artery puncture. Blood samples were collected under anesthesia from the left ventricles of the heart using the cardiac puncture method for IMA measurement. Histopathological examinations were performed on the heart and lung tissues. Albumin with by colorimetric, creatine kinase (CK), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) were determined on an automatic analyser using the enzymatic method. IMA using by ACB test was detected with spectrophotometer.Results: Serum IMA (p = 0.044) in seventh day of SAH were higher compared to the control group. Total injury scores of heart and lung tissue, also myocytolysis at day 7 were significantly higher than control group (p = 0.001, p = 0.001, p = 0.001), day 1 (p = 0.001, p = 0.001, p = 0.001) and day 2 (p = 0.001, p = 0.007, p = 0.001). A positive correlation between IMA - myocytolysis (r = 0.48, p = 0.008), and between IMA - heart tissue total injury score (r = 0.41, p = 0.029) was found.Conclusion: The results revealed that increased serum IMA may be related to myocardial stress after SAH. © 2014 Açi{dotless}kgöz et al.; licensee BioMed Central Ltd.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Cardiac damage
Konu Başlıkları
[dc.subject]
Experimental subarachnoid hemorrhage
Konu Başlıkları
[dc.subject]
Ischemia modified albumin
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1471-2202
Dergi Adı
[dc.relation.journal]
BMC Neuroscience
Dergi Cilt Bilgisi
[dc.identifier.volume]
15
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1186/1471-2202-15-33
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/6413
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52
09.12.2022 tarihinden bu yana
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1
09.12.2022 tarihinden bu yana
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control seventh injury higher between myocytolysis groups tissue method albumin puncture scores compared kinase aspartate aminotransferase dehydrogenase lactate Results determined automatic analyser enzymatic detected spectrophotometer Background increased related myocardial stress results Açi{dotless}kgöz licensee BioMed Central
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