Biological importance of podoplanin expression in chorionic villous stromal cells and its relationship to placental pathologies

Podoplanin, a reliable marker of lymphatic endothelium, is a mucin-type transmembrane protein. Although the human placenta is devoid of a lymphatic system, chorionic villous stromal (CVS) cells express podoplanin. In this study, the pattern of podoplanin expression in normal and pathological placental tissues and the biological role of podoplanin were investigated. In total, 198 placental tissues belonging to 184 patients, seen at the Department of Pathology of Bulent Ecevit University Education and Research Hospital, Zonguldak, Turkey, were evaluated histopathologically and determined to meet the study criteria. The tissues were assigned to control, cisternal placental disorders, inflammation and hypoxic-ischemic pathology groups. Podoplanin expression in CVS cells was graded from 0 to 3 depending on the staining intensity, as determined by an immunohistochemical evaluation of chorionic villi in the most intensively stained tissue region. Podoplanin levels in control CVS cells increased in parallel with placental maturation, whereas in molar pregnancies podoplanin expression was lower than in control tissues. In the acute placental inflammation group, podoplanin immunoreactivity was similar to that in the control group, whereas in the preeclampsia group, podoplanin expression was higher than in all other groups. Our study showed an increase in podoplanin expression in CVS cells during pregnancy. In preeclamptic patients, the increase in podoplanin expression may be a response to hypoxic-ischemic conditions, whereas in molar pregnancies the decrease in podoplanin levels may cause villous swelling by disrupting intercellular fluid homeostasis. © 2019, The Author(s).

Yazar Onak Kandemir N.
Barut F.
Barut A.
Birol İ.E.
Dogan Gun B.
Ozdamar S.O.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/4510
Tek Biçim Adres 10.1038/s41598-019-50652-9
Koleksiyonlar Fakülteler
Tıp Fakültesi
Cerrahi Bilimler Bölümü
Makale Koleksiyonu (Cerrahi Bilimler Bölümü)
Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Scientific Reports
Dergi Cilt Bilgisi 9
Dergi Sayısı 1
Sayfalar -
Yayın Yılı 2019
Eser Adı
[dc.title]
Biological importance of podoplanin expression in chorionic villous stromal cells and its relationship to placental pathologies
Yazar
[dc.contributor.author]
Onak Kandemir N.
Yazar
[dc.contributor.author]
Barut F.
Yazar
[dc.contributor.author]
Barut A.
Yazar
[dc.contributor.author]
Birol İ.E.
Yazar
[dc.contributor.author]
Dogan Gun B.
Yazar
[dc.contributor.author]
Ozdamar S.O.
Yayın Yılı
[dc.date.issued]
2019
Yayıncı
[dc.publisher]
Nature Publishing Group
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Podoplanin, a reliable marker of lymphatic endothelium, is a mucin-type transmembrane protein. Although the human placenta is devoid of a lymphatic system, chorionic villous stromal (CVS) cells express podoplanin. In this study, the pattern of podoplanin expression in normal and pathological placental tissues and the biological role of podoplanin were investigated. In total, 198 placental tissues belonging to 184 patients, seen at the Department of Pathology of Bulent Ecevit University Education and Research Hospital, Zonguldak, Turkey, were evaluated histopathologically and determined to meet the study criteria. The tissues were assigned to control, cisternal placental disorders, inflammation and hypoxic-ischemic pathology groups. Podoplanin expression in CVS cells was graded from 0 to 3 depending on the staining intensity, as determined by an immunohistochemical evaluation of chorionic villi in the most intensively stained tissue region. Podoplanin levels in control CVS cells increased in parallel with placental maturation, whereas in molar pregnancies podoplanin expression was lower than in control tissues. In the acute placental inflammation group, podoplanin immunoreactivity was similar to that in the control group, whereas in the preeclampsia group, podoplanin expression was higher than in all other groups. Our study showed an increase in podoplanin expression in CVS cells during pregnancy. In preeclamptic patients, the increase in podoplanin expression may be a response to hypoxic-ischemic conditions, whereas in molar pregnancies the decrease in podoplanin levels may cause villous swelling by disrupting intercellular fluid homeostasis. © 2019, The Author(s).
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
2045-2322
Dergi Adı
[dc.relation.journal]
Scientific Reports
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
9
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1038/s41598-019-50652-9
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4510
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
22
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 10:20
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podoplanin expression placental control tissues whereas Podoplanin increase patients lymphatic levels determined villous hypoxic-ischemic chorionic groups inflammation pregnancies maturation increased parallel stained immunohistochemical region tissue evaluation intensively response Author(s) homeostasis intercellular disrupting swelling decrease conditions
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