Cavernous hemangioma-like Kaposi sarcoma: Histomorphologic features and differential diagnosis

Aim. Cavernous hemangioma-like Kaposi sarcoma is a rare morphologic type of Kaposi sarcoma. So far there are no cases in the literature defining the histological features of this morphologic spectrum in detail. In this study we presented two classical-type cutaneous Kaposi sarcoma cases with histologic findings resembling cavernous hemangioma in company with clinical and histopathological data. Cases. One hundred and eighty-five classical-type cutaneous Kaposi sarcoma lesions in 79 patients were assessed retrospectively in terms of histopathological features. Findings of two cases showing features of cavernous hemangioma-like Kaposi sarcoma whose clinical data could be accessed were presented in accompany with the literature data. Both cases were detected to have bluish-purple, protruded, irregularly bordered cutaneous lesions. Histopathological examination revealed a lesion formed by cavernous hemangioma-like vascular structures organized in a lobular pattern that became dilated and filled with blood. Typical histological findings of early-stage KS, consisting of mononuclear inflammation, extravasated erythrocytes, and a few immature vascular structures in superficial dermis, were observed. All cases were serologically HIV-1 negative. A positive reaction with HHV-8, CD31, CD34, and D2-40 monoclonal antibodies was identified at both cavernous hemangioma-like areas and in immature vascular structures. Results. Cavernous hemangioma-like Kaposi sarcoma is a rare Kaposi sarcoma variant presenting with diagnostic challenges, that may be confused with hemangioma. As characteristic morphological features may not be observed in every case, it is important for diagnostic purposes to show immunohistochemical HHV-8 positivity in this variant. © 2013 Nilüfer Onak Kandemir et al.

Yazar Onak Kandemir N.
Barut F.
Dogan Gün B.
Solak Tekin N.
Hallaç Keser S.
Oguz Özdamar Ş.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/4601
Tek Biçim Adres 10.1155/2013/959812
Koleksiyonlar Fakülteler
Tıp Fakültesi
Cerrahi Bilimler Bölümü
Makale Koleksiyonu (Cerrahi Bilimler Bölümü)
Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı Case Reports in Medicine
Dergi Cilt Bilgisi 2013
Sayfalar -
Yayın Yılı 2013
Eser Adı
[dc.title]
Cavernous hemangioma-like Kaposi sarcoma: Histomorphologic features and differential diagnosis
Yazar
[dc.contributor.author]
Onak Kandemir N.
Yazar
[dc.contributor.author]
Barut F.
Yazar
[dc.contributor.author]
Dogan Gün B.
Yazar
[dc.contributor.author]
Solak Tekin N.
Yazar
[dc.contributor.author]
Hallaç Keser S.
Yazar
[dc.contributor.author]
Oguz Özdamar Ş.
Yayın Yılı
[dc.date.issued]
2013
Yayıncı
[dc.publisher]
Hindawi Limited
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Aim. Cavernous hemangioma-like Kaposi sarcoma is a rare morphologic type of Kaposi sarcoma. So far there are no cases in the literature defining the histological features of this morphologic spectrum in detail. In this study we presented two classical-type cutaneous Kaposi sarcoma cases with histologic findings resembling cavernous hemangioma in company with clinical and histopathological data. Cases. One hundred and eighty-five classical-type cutaneous Kaposi sarcoma lesions in 79 patients were assessed retrospectively in terms of histopathological features. Findings of two cases showing features of cavernous hemangioma-like Kaposi sarcoma whose clinical data could be accessed were presented in accompany with the literature data. Both cases were detected to have bluish-purple, protruded, irregularly bordered cutaneous lesions. Histopathological examination revealed a lesion formed by cavernous hemangioma-like vascular structures organized in a lobular pattern that became dilated and filled with blood. Typical histological findings of early-stage KS, consisting of mononuclear inflammation, extravasated erythrocytes, and a few immature vascular structures in superficial dermis, were observed. All cases were serologically HIV-1 negative. A positive reaction with HHV-8, CD31, CD34, and D2-40 monoclonal antibodies was identified at both cavernous hemangioma-like areas and in immature vascular structures. Results. Cavernous hemangioma-like Kaposi sarcoma is a rare Kaposi sarcoma variant presenting with diagnostic challenges, that may be confused with hemangioma. As characteristic morphological features may not be observed in every case, it is important for diagnostic purposes to show immunohistochemical HHV-8 positivity in this variant. © 2013 Nilüfer Onak Kandemir et al.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1687-9627
Dergi Adı
[dc.relation.journal]
Case Reports in Medicine
Dergi Cilt Bilgisi
[dc.identifier.volume]
2013
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1155/2013/959812
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4601
Görüntülenme Sayısı ( Şehir )
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29
09.12.2022 tarihinden bu yana
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1
09.12.2022 tarihinden bu yana
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08 Şubat 2024 07:25
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sarcoma Kaposi hemangioma-like cavernous features vascular structures cutaneous histopathological clinical lesions hemangioma findings diagnostic variant presented classical-type observed Cavernous morphologic immature histological literature erythrocytes monoclonal antibodies reaction superficial dermis positive serologically negative identified Kandemir Nilüfer
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