The value of cytokeratin-19 immunohistochemistry in the differential diagnosis of papillary thyroid carcinomas

Objective: The gold standard for diagnosis of papillary thyroid carcinoma is conventional histology, which depends on the characteristic nuclear features, regardless of whether papillary architecture is present or not. This study was carried on to evaluate the utility of cytokeratin-19 in the diagnosis and differential diagnosis of papillary thyroid carcinoma. Material and Methods: Expression of cytokeratin-19 was tested on formalin-fixed, paraffin-embedded tissues from 380 surgically resected thyroid lesions including hyperplasic nodules (n= 243), granulomatous thyroiditis (n= 3), lymphocytic (n= 53) and Hashimoto's thyroiditis (n= 11), follicular adenomas (n= 17), Hurthle cell adenomas (n= 4), well-differentiated thyroid tumor with follicular architecture of uncertain malignant potenti al (n= 1), papillary carcinomas (n= 45), follicular carcinoma (n= 1), insular carcinoma (n= 1), and medullary carcinoma (n= 1). The immunoreactivity was scored as negative, 1+, 2+, 3+, and 4+, based on the extent of the reaction regardless of previous diagnosis. Results: Positive reaction with cytokeratin-19 was denoted in all of the 45 cases of papillary carcino mas with scores of 4+, 3+ and 2+ and the ratios were 57.8% (26/45), 33.3% (15/45) and 8.9% (4/45), respectively. There seemed to be a strong diffuse cytoplasmic reactivity with cytokeratin-19 in papillary thyroid carcinomas. The sensitivity and specificity for cytokeratin-19 in papillary carcinomas among neoplastic thyroid lesions were 91.8% and 86.2%, respectively. Conclusion: In additi on to careful histological evaluation, cytokeratin-19 seems useful for the diagnosis of papillary thyroid carcinomas. Copyright © 2009 by Türkiye Klinikleri.

Dergi Adı Turkiye Klinikleri Journal of Medical Sciences
Dergi Cilt Bilgisi 29
Dergi Sayısı 1
Sayfalar 42 - 47
Yayın Yılı 2009
Eser Adı
[dc.title]
The value of cytokeratin-19 immunohistochemistry in the differential diagnosis of papillary thyroid carcinomas
Yazar
[dc.contributor.author]
Barut F.
Yazar
[dc.contributor.author]
Bektaş S.
Yazar
[dc.contributor.author]
Bahadir B.
Yazar
[dc.contributor.author]
Onak Kandemir N.
Yazar
[dc.contributor.author]
Karadayi N.
Yazar
[dc.contributor.author]
Özdamar Ş.O.
Yayın Yılı
[dc.date.issued]
2009
Yayıncı
[dc.publisher]
Turkiye Klinikleri
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: The gold standard for diagnosis of papillary thyroid carcinoma is conventional histology, which depends on the characteristic nuclear features, regardless of whether papillary architecture is present or not. This study was carried on to evaluate the utility of cytokeratin-19 in the diagnosis and differential diagnosis of papillary thyroid carcinoma. Material and Methods: Expression of cytokeratin-19 was tested on formalin-fixed, paraffin-embedded tissues from 380 surgically resected thyroid lesions including hyperplasic nodules (n= 243), granulomatous thyroiditis (n= 3), lymphocytic (n= 53) and Hashimoto's thyroiditis (n= 11), follicular adenomas (n= 17), Hurthle cell adenomas (n= 4), well-differentiated thyroid tumor with follicular architecture of uncertain malignant potenti al (n= 1), papillary carcinomas (n= 45), follicular carcinoma (n= 1), insular carcinoma (n= 1), and medullary carcinoma (n= 1). The immunoreactivity was scored as negative, 1+, 2+, 3+, and 4+, based on the extent of the reaction regardless of previous diagnosis. Results: Positive reaction with cytokeratin-19 was denoted in all of the 45 cases of papillary carcino mas with scores of 4+, 3+ and 2+ and the ratios were 57.8% (26/45), 33.3% (15/45) and 8.9% (4/45), respectively. There seemed to be a strong diffuse cytoplasmic reactivity with cytokeratin-19 in papillary thyroid carcinomas. The sensitivity and specificity for cytokeratin-19 in papillary carcinomas among neoplastic thyroid lesions were 91.8% and 86.2%, respectively. Conclusion: In additi on to careful histological evaluation, cytokeratin-19 seems useful for the diagnosis of papillary thyroid carcinomas. Copyright © 2009 by Türkiye Klinikleri.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Carcinoma, papillary
Konu Başlıkları
[dc.subject]
Cytokeratin-19
Konu Başlıkları
[dc.subject]
Thyroid nodule
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1300-0292
İlk Sayfa Sayısı
[dc.identifier.startpage]
42
Son Sayfa Sayısı
[dc.identifier.endpage]
47
Dergi Adı
[dc.relation.journal]
Turkiye Klinikleri Journal of Medical Sciences
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
29
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/8312
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
50
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
21 Şubat 2024 03:46
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papillary thyroid cytokeratin-19 carcinoma diagnosis carcinomas follicular adenomas thyroiditis respectively lesions architecture regardless reaction (26/45) extent ratios previous Results Positive denoted scores carcino (15/45) Objective Conclusion Klinikleri Türkiye Copyright useful evaluation histological careful additi neoplastic
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