Lymphatic differentiation in classic Kaposi's sarcoma: Patterns of D2-40 immunoexpression in the course of tumor progression

The recent development of lymphatic endotheliumspecific immuno-indicators has given rise to research on the histogenesis of Kaposi sarcoma (KS), specifically focusing on its lymphatic root and differentiation. D2-40 is a new lymphatic marker that recognizes podoplanin and is easily applied to formalin-fixed paraffin-embedded human tissues. This study examined D2-40 immunoexpression in 178 classical KS lesions using immunohistochemical methods. D2-40 immunoexpression was also examined in 63 non-KS soft tissue lesions to test the reliability of D2-40 monoclonal antibody in the pathological diagnosis of KS. D2-40 immunoreactivity was detected at all of the KS lesions and in lymphangioma and nonneoplastic lymphatic endothelium. There was no significant relationship between the extent of D2-40 staining and histopathological stage;however, there was a positive correlation between the staining intensity and histopathological stage in KS cases. D2-40 immunoreactivity was detected at all histopathological stages of KS and may be added to the routine immunohistochemical panel used for the differential diagnosis of KS. Widespread D2-40 protein expression is evidence of a lymphatic origin or the differentiation of neoplastic cells in KS, and D2-40 expression increases with tumor progression. © Arányi Lajos Foundation 2011.

Dergi Adı Pathology and Oncology Research
Dergi Cilt Bilgisi 17
Dergi Sayısı 4
Sayfalar 843 - 851
Yayın Yılı 2011
Eser Adı
[dc.title]
Lymphatic differentiation in classic Kaposi's sarcoma: Patterns of D2-40 immunoexpression in the course of tumor progression
Yazar
[dc.contributor.author]
Kandemir N.O.
Yazar
[dc.contributor.author]
Barut F.
Yazar
[dc.contributor.author]
Gun B.D.
Yazar
[dc.contributor.author]
Keser S.H.
Yazar
[dc.contributor.author]
Karadayi N.
Yazar
[dc.contributor.author]
Gun M.
Yazar
[dc.contributor.author]
Ozdamar S.O.
Yayın Yılı
[dc.date.issued]
2011
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
The recent development of lymphatic endotheliumspecific immuno-indicators has given rise to research on the histogenesis of Kaposi sarcoma (KS), specifically focusing on its lymphatic root and differentiation. D2-40 is a new lymphatic marker that recognizes podoplanin and is easily applied to formalin-fixed paraffin-embedded human tissues. This study examined D2-40 immunoexpression in 178 classical KS lesions using immunohistochemical methods. D2-40 immunoexpression was also examined in 63 non-KS soft tissue lesions to test the reliability of D2-40 monoclonal antibody in the pathological diagnosis of KS. D2-40 immunoreactivity was detected at all of the KS lesions and in lymphangioma and nonneoplastic lymphatic endothelium. There was no significant relationship between the extent of D2-40 staining and histopathological stage;however, there was a positive correlation between the staining intensity and histopathological stage in KS cases. D2-40 immunoreactivity was detected at all histopathological stages of KS and may be added to the routine immunohistochemical panel used for the differential diagnosis of KS. Widespread D2-40 protein expression is evidence of a lymphatic origin or the differentiation of neoplastic cells in KS, and D2-40 expression increases with tumor progression. © Arányi Lajos Foundation 2011.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
D2-40
Konu Başlıkları
[dc.subject]
Immunohistochemistry
Konu Başlıkları
[dc.subject]
Kaposi sarcoma
Konu Başlıkları
[dc.subject]
Lymphatic
Konu Başlıkları
[dc.subject]
Podoplanin
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1219-4956
İlk Sayfa Sayısı
[dc.identifier.startpage]
843
Son Sayfa Sayısı
[dc.identifier.endpage]
851
Dergi Adı
[dc.relation.journal]
Pathology and Oncology Research
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
17
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/s12253-011-9392-9
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/6522
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
23
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 13:13
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Tıklayınız
lymphatic lesions histopathological expression differentiation immunohistochemical immunoexpression staining examined diagnosis between detected immunoreactivity correlation positive intensity extent however significant relationship endothelium Foundation Arányi progression increases neoplastic origin stages evidence protein Widespread differential nonneoplastic routine tissue
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