The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules

Aim. Insulin-like growth factor-1 (IGF-1) is a potent mitogen for many cells. IGF-1 plays a role in the pathogenesis of various tumors with its mutagenic and antiapoptotic properties. The aim of this study was to determine both the serum and intranodular levels of IGF-1 and insulin-like growth factor binding protein-3 (IGFBP-3) in patients with nodular thyroid diseases. Materials and Methods. In this study, 80 subjects who performed fine-needle aspiration biopsy (FNAB) were required in order to investigate the effects of serum and intranodular IGF-1 and IGFBP-3 in the pathogenesis of nodules. After performing FNAB, IGF-1 and IGFBP-3 levels were determined in blood and aspiration samples. Results. The serum levels of IGF-1 (232.8 ± 12.9 ng/ml) and IGFBP-3 (4.8 µg/ml) were found significantly higher than that of the intranodular IGF-1 (39.1 ng/ml) and intranodular IGFBP-3 levels (0.173 µg/ml) (p<0.01). Intranodular levels of IGF-1 and IGFBP-3 were higher in subjects with multinodular thyroid gland than those of subjects with solitary nodules (p=0.043). A positive correlation between the nodule size and the serum IGFBP-3 levels was detected (p=0.042, r=0.23). Conclusion. This study demonstrated the possible role of both IGF-1 and IGFBP-3 in the growth and the formation of multinodularity of thyroid nodules. © 2017 Ayfer Altas et al.

Dergi Adı International Journal of Endocrinology
Dergi Cilt Bilgisi 2017
Sayfalar -
Yayın Yılı 2017
Eser Adı
[dc.title]
The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules
Yazar
[dc.contributor.author]
Altas A.
Yazar
[dc.contributor.author]
Kuzu F.
Yazar
[dc.contributor.author]
Arpaci D.
Yazar
[dc.contributor.author]
Unal M.
Yazar
[dc.contributor.author]
Can M.
Yazar
[dc.contributor.author]
Barut F.
Yazar
[dc.contributor.author]
Kokturk F.
Yayın Yılı
[dc.date.issued]
2017
Yayıncı
[dc.publisher]
Hindawi Limited
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Aim. Insulin-like growth factor-1 (IGF-1) is a potent mitogen for many cells. IGF-1 plays a role in the pathogenesis of various tumors with its mutagenic and antiapoptotic properties. The aim of this study was to determine both the serum and intranodular levels of IGF-1 and insulin-like growth factor binding protein-3 (IGFBP-3) in patients with nodular thyroid diseases. Materials and Methods. In this study, 80 subjects who performed fine-needle aspiration biopsy (FNAB) were required in order to investigate the effects of serum and intranodular IGF-1 and IGFBP-3 in the pathogenesis of nodules. After performing FNAB, IGF-1 and IGFBP-3 levels were determined in blood and aspiration samples. Results. The serum levels of IGF-1 (232.8 ± 12.9 ng/ml) and IGFBP-3 (4.8 µg/ml) were found significantly higher than that of the intranodular IGF-1 (39.1 ng/ml) and intranodular IGFBP-3 levels (0.173 µg/ml) (p<0.01). Intranodular levels of IGF-1 and IGFBP-3 were higher in subjects with multinodular thyroid gland than those of subjects with solitary nodules (p=0.043). A positive correlation between the nodule size and the serum IGFBP-3 levels was detected (p=0.042, r=0.23). Conclusion. This study demonstrated the possible role of both IGF-1 and IGFBP-3 in the growth and the formation of multinodularity of thyroid nodules. © 2017 Ayfer Altas et al.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1687-8337
Dergi Adı
[dc.relation.journal]
International Journal of Endocrinology
Dergi Cilt Bilgisi
[dc.identifier.volume]
2017
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1155/2017/3145234
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7866
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
32
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
18 Şubat 2024 08:19
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IGFBP-3 levels intranodular subjects thyroid nodules growth higher aspiration ng/ml) pathogenesis µg/ml) multinodular Intranodular significantly multinodularity formation possible demonstrated Conclusion solitary detected nodule between correlation positive various factor insulin-like determine properties antiapoptotic mutagenic tumors protein-3
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