Malignant melanoma associated with congenital melanocytic nevus and diagnosed with intestinal metastases: Two case reports

Congenital melanocytic nevi are hamartomatous lesions that develop from the neural crest and arise during odontogenesis. In this report, we present two malignant melanoma cases developed from congenital melanocytic nevi and revealed by gastrointestinal system metastases. The first case was a 71-year-old female who presented with pleural and peritoneal effusion and underwent biopsy due to detection of nodular lesions in the duodenum by endoscopic examination. The second case was a 36-year-old male patient who presented with abdominal pain in whom segmental ileal resection was performed due to mass lesions causing invaginations in the ileum. Histopathological examination of the lesions showed a diffuse neoplastic infiltration comprising the entire mucosal layers. In neoplastic cells having a marked atypia and pleomorphism, immunoreactions with S-100, HMB-45, and Melan A were detected. Both cases were diagnosed as malignant melanoma. Abdominal skin in the first case and the femoral region in the second case exhibited congenital melanocytic nevi, and those lesions were determined to show a transformation towards malignant melanoma in the histopathological studies. Malignant melanoma development in gastrointestinal system may have a primary or metastatic character. Definitive diagnosis always requires detailed clinical, histopathological and immunohistochemical analyses.

Yazar Onak Kandemir N.
Bahadir B.
Bektaş S.
Barut F.
Yurdakan G.
Dogan Gün B.
Engin H.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/6541
Tek Biçim Adres 10.4318/tjg.2011.0161
Konu Başlıkları Congenital melanocytic nevi
Gastrointestinal system
Malignant melanoma
Koleksiyonlar Fakülteler
Tıp Fakültesi
Cerrahi Bilimler Bölümü
Makale Koleksiyonu (Cerrahi Bilimler Bölümü)
Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı Turkish Journal of Gastroenterology
Dergi Cilt Bilgisi 22
Dergi Sayısı 1
Sayfalar 77 - 82
Yayın Yılı 2011
Eser Adı
[dc.title]
Malignant melanoma associated with congenital melanocytic nevus and diagnosed with intestinal metastases: Two case reports
Yazar
[dc.contributor.author]
Onak Kandemir N.
Yazar
[dc.contributor.author]
Bahadir B.
Yazar
[dc.contributor.author]
Bektaş S.
Yazar
[dc.contributor.author]
Barut F.
Yazar
[dc.contributor.author]
Yurdakan G.
Yazar
[dc.contributor.author]
Dogan Gün B.
Yazar
[dc.contributor.author]
Engin H.
Yayın Yılı
[dc.date.issued]
2011
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Congenital melanocytic nevi are hamartomatous lesions that develop from the neural crest and arise during odontogenesis. In this report, we present two malignant melanoma cases developed from congenital melanocytic nevi and revealed by gastrointestinal system metastases. The first case was a 71-year-old female who presented with pleural and peritoneal effusion and underwent biopsy due to detection of nodular lesions in the duodenum by endoscopic examination. The second case was a 36-year-old male patient who presented with abdominal pain in whom segmental ileal resection was performed due to mass lesions causing invaginations in the ileum. Histopathological examination of the lesions showed a diffuse neoplastic infiltration comprising the entire mucosal layers. In neoplastic cells having a marked atypia and pleomorphism, immunoreactions with S-100, HMB-45, and Melan A were detected. Both cases were diagnosed as malignant melanoma. Abdominal skin in the first case and the femoral region in the second case exhibited congenital melanocytic nevi, and those lesions were determined to show a transformation towards malignant melanoma in the histopathological studies. Malignant melanoma development in gastrointestinal system may have a primary or metastatic character. Definitive diagnosis always requires detailed clinical, histopathological and immunohistochemical analyses.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Congenital melanocytic nevi
Konu Başlıkları
[dc.subject]
Gastrointestinal system
Konu Başlıkları
[dc.subject]
Malignant melanoma
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1300-4948
İlk Sayfa Sayısı
[dc.identifier.startpage]
77
Son Sayfa Sayısı
[dc.identifier.endpage]
82
Dergi Adı
[dc.relation.journal]
Turkish Journal of Gastroenterology
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
22
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.4318/tjg.2011.0161
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/6541
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
36
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 10:24
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Tıklayınız
lesions melanoma malignant melanocytic congenital second presented system gastrointestinal examination histopathological neoplastic marked femoral layers Abdominal having detected atypia pleomorphism immunoreactions HMB-45 diagnosed Congenital region analyses immunohistochemical clinical detailed requires always diagnosis Definitive character metastatic
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