The effect of generalized seizure activity on ischemia-induced cardiac arrhythmias and myocardial injury with histopathological evaluation in anesthetized rats

Background/aim: Epileptic seizure leads to sudden unexpected death in epilepsy (SUDEP) among affected patients. The causes of SUDEP are still unclear. The aim of this study was to research the effect of epilepsy on myocardial injury and arrhythmias during experimentally induced acute myocardial ischemia. Materials and methods: Wistar albino rats were divided into four groups: sham, pentylentetrazole (PTZ) + sham, ischemia, and PTZ + ischemia groups. PTZ (65 mg/kg, ip) was given 2 h before ischemia. Seizure scoring was conducted by evaluating the PTZ-induced behavioral changes in the rats. The left main coronary artery was ligated in anesthetized rats for 30 min. The incidence and the number of ventricular arrhythmias were determined. Histopathological scoring was performed for tissue injury by using a microscope. Results: Seizure scores were not different among the groups (P > 0.05). The incidence and number of ventricular tachycardia (VT) episodes were significantly higher in the PTZ + ischemia group than in the ischemia group (P ? 0.05). More prominent myocardial damage was observed in the PTZ + ischemia group than in the other groups (histopathological scores: PTZ + ischemia; 2.5 ± 0.5 versus ischemia; 1.2 ± 0.4, P ? 0.05). Conclusion: PTZ-induced seizure in rats increased myocardial injury and the incidence and number of VT episodes in myocardial ischemia. These results reveal that seizure in epilepsy patients may increase ventricular arrhythmia and myocardial injury during heart attack. © TÜBİTAK.

Dergi Adı Turkish Journal of Medical Sciences
Dergi Cilt Bilgisi 48
Dergi Sayısı 6
Sayfalar 1293 - 1301
Yayın Yılı 2018
Eser Adı
[dc.title]
The effect of generalized seizure activity on ischemia-induced cardiac arrhythmias and myocardial injury with histopathological evaluation in anesthetized rats
Yazar
[dc.contributor.author]
Gonca E.
Yazar
[dc.contributor.author]
Barut F.
Yazar
[dc.contributor.author]
Şahin D.
Yayın Yılı
[dc.date.issued]
2018
Yayıncı
[dc.publisher]
Turkiye Klinikleri Journal of Medical Sciences
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background/aim: Epileptic seizure leads to sudden unexpected death in epilepsy (SUDEP) among affected patients. The causes of SUDEP are still unclear. The aim of this study was to research the effect of epilepsy on myocardial injury and arrhythmias during experimentally induced acute myocardial ischemia. Materials and methods: Wistar albino rats were divided into four groups: sham, pentylentetrazole (PTZ) + sham, ischemia, and PTZ + ischemia groups. PTZ (65 mg/kg, ip) was given 2 h before ischemia. Seizure scoring was conducted by evaluating the PTZ-induced behavioral changes in the rats. The left main coronary artery was ligated in anesthetized rats for 30 min. The incidence and the number of ventricular arrhythmias were determined. Histopathological scoring was performed for tissue injury by using a microscope. Results: Seizure scores were not different among the groups (P > 0.05). The incidence and number of ventricular tachycardia (VT) episodes were significantly higher in the PTZ + ischemia group than in the ischemia group (P ? 0.05). More prominent myocardial damage was observed in the PTZ + ischemia group than in the other groups (histopathological scores: PTZ + ischemia; 2.5 ± 0.5 versus ischemia; 1.2 ± 0.4, P ? 0.05). Conclusion: PTZ-induced seizure in rats increased myocardial injury and the incidence and number of VT episodes in myocardial ischemia. These results reveal that seizure in epilepsy patients may increase ventricular arrhythmia and myocardial injury during heart attack. © TÜBİTAK.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Epilepsy
Konu Başlıkları
[dc.subject]
Myocardial injury
Konu Başlıkları
[dc.subject]
Pentylentetrazole
Konu Başlıkları
[dc.subject]
Rat
Konu Başlıkları
[dc.subject]
Ventricular arrhythmias
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1300-0144
Sponsor YAYINCI
[dc.description.sponsorship]
Firat University Scientific Research Projects Management Unit: 05 Bülent Ecevit Üniversitesi
Sponsor YAYINCI
[dc.description.sponsorship]
The authors disclose receipt of the following financial support for the research of this article (Research fund grant from Zonguldak Bülent Ecevit University, Scientific Research Projects Unit (No: 2015 - 84906727 - 05)).
İlk Sayfa Sayısı
[dc.identifier.startpage]
1293
Son Sayfa Sayısı
[dc.identifier.endpage]
1301
Dergi Adı
[dc.relation.journal]
Turkish Journal of Medical Sciences
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
48
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.3906/sag-1807-99
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7934
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
33
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 19:42
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Tıklayınız
ischemia myocardial injury groups ventricular number seizure incidence epilepsy episodes Seizure during arrhythmias PTZ-induced scores patients scoring performed tachycardia tissue microscope Results different Background/aim significantly TÜBİTAK attack arrhythmia increase reveal results increased higher Conclusion versus
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