Visfatin levels in gingival crevicular fluid and serum before and after non-surgical treatment for periodontal diseases

The purpose of this study was to evaluate visfatin levels at different stages of periodontal disease and in healthy tissues. In addition, the effect of non-surgical periodontal therapy on visfatin levels in gingival crevicular fluid and serum was investigated. Forty-five patients were divided into three groups based on clinical and radiographical findings. Group 1 comprised periodontally healthy individuals (n = 15); group 2 comprised patients with gingivitis (n = 15); and group 3 was composed of patients with generalized chronic periodontitis (n = 15). Gingival crevicular fluid and serum samples were collected before treatment and at 1, 3, and 6 months after treatment. Visfatin levels were measured by enzyme-linked immunosorbent assays. Gingival crevicular fluid and serum visfatin levels were higher in patients with chronic periodontitis than those with gingivitis or healthy controls (P < 0.016). In addition, visfatin levels were higher in the gingivitis group than in healthy controls (P < 0.016). Non-surgical periodontal treatment resulted in a significant reduction in gingival crevicular fluid and serum visfatin levels. Furthermore, visfatin levels increased with inflammation and decreased following periodontal treatment. Our findings suggest that visfatin is an inflammatorybiomarker of periodontal disease. ? 2016, Universidad de Granada. All rights reserved.

Yazar Türer, Çğdem Coşkun
Ballı, U.
Güven B.
Çetinkaya, B.
Çayır Keleş, G.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/8505
Tek Biçim Adres 10.2334/josnusd.16-0116
Konu Başlıkları Gingival crevicular fluid
Periodontal disease
Post-treatment
Serum
Visfatin
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Journal of Oral Science
Dergi Cilt Bilgisi 58
Dergi Sayısı 4
Sayfalar 491 - 499
Yayın Yılı 2016
Eser Adı
[dc.title]
Visfatin levels in gingival crevicular fluid and serum before and after non-surgical treatment for periodontal diseases
Yazar
[dc.contributor.author]
Türer, Çğdem Coşkun
Yazar
[dc.contributor.author]
Ballı, U.
Yazar
[dc.contributor.author]
Güven B.
Yazar
[dc.contributor.author]
Çetinkaya, B.
Yazar
[dc.contributor.author]
Çayır Keleş, G.
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
Nihon University, School of Dentistry
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
The purpose of this study was to evaluate visfatin levels at different stages of periodontal disease and in healthy tissues. In addition, the effect of non-surgical periodontal therapy on visfatin levels in gingival crevicular fluid and serum was investigated. Forty-five patients were divided into three groups based on clinical and radiographical findings. Group 1 comprised periodontally healthy individuals (n = 15); group 2 comprised patients with gingivitis (n = 15); and group 3 was composed of patients with generalized chronic periodontitis (n = 15). Gingival crevicular fluid and serum samples were collected before treatment and at 1, 3, and 6 months after treatment. Visfatin levels were measured by enzyme-linked immunosorbent assays. Gingival crevicular fluid and serum visfatin levels were higher in patients with chronic periodontitis than those with gingivitis or healthy controls (P < 0.016). In addition, visfatin levels were higher in the gingivitis group than in healthy controls (P < 0.016). Non-surgical periodontal treatment resulted in a significant reduction in gingival crevicular fluid and serum visfatin levels. Furthermore, visfatin levels increased with inflammation and decreased following periodontal treatment. Our findings suggest that visfatin is an inflammatorybiomarker of periodontal disease. ? 2016, Universidad de Granada. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Gingival crevicular fluid
Konu Başlıkları
[dc.subject]
Periodontal disease
Konu Başlıkları
[dc.subject]
Post-treatment
Konu Başlıkları
[dc.subject]
Serum
Konu Başlıkları
[dc.subject]
Visfatin
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1343-4934
Sponsor YAYINCI
[dc.description.sponsorship]
2013-62550515-04
Sponsor YAYINCI
[dc.description.sponsorship]
This work was supported by Research Fund of Ondokuz May?s University Project (Number: 2013-62550515-04).
İlk Sayfa Sayısı
[dc.identifier.startpage]
491
Son Sayfa Sayısı
[dc.identifier.endpage]
499
Dergi Adı
[dc.relation.journal]
Journal of Oral Science
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
58
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.2334/josnusd.16-0116
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/8505
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
12
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
04 Şubat 2024 03:06
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visfatin levels periodontal patients healthy crevicular treatment gingivitis findings chronic gingival disease higher controls comprised addition Gingival periodontitis resulted Non-surgical suggest reserved rights Granada Universidad inflammatorybiomarker significant immunosorbent following decreased inflammation increased Furthermore reduction assays
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