Influence of Vitamin C and e supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection

Background/Aims: In our study, we aimed to assess the effect of vitamin E and C supplementation to triple and quadruple Helicobacter pylori eradication regimens. Materials and Methods: Four hundred patients with H. pylori infection were classified into four groups. Patients in group A (n=100) received amoxicillin, clarithromycin, and lansoprazole for 2 weeks. In group B, patients (n=100) received vitamins C and E for a month, in addition to amoxicillin, clarithromycin, and lansoprazole for 2 weeks. Patients in group C (n=100) received amoxicillin, clarithromycin, lansoprazole, and bismuth subcitrate for 2 weeks, whereas those in group D (n=100) received vitamins C and E for a month, in addition to amoxicillin, clarithromycin, lansoprazole, and bismuth subcitrate for 2 weeks. H. pylori eradication was assessed with the C14 urea breath test 2 months after the end of the therapy. The eradication rate was assessed using per-protocol (PP) and intention-to-treat (ITT) analyses. Results: Three hundred forty-eight patients finished the study. The eradication of H. pylori was achieved in 63 of 84 patients (75%) by PP and 63 of 100 (63%) by ITT analysis in group A, 60 of 84 (71.4%) by PP and 60 of 100 (60%) by ITT analysis in group B, 72 of 89 (80.9 %) by PP and 72 of 100 (72%) by ITT analysis in group C, and 76 of 91 (83.5%) by PP and 76 of 100 (76%) by ITT analysis in group D. There was no remarkable change between groups A and B (p>0.05). Similar results were also found between groups D and C (p>0.05). Conclusion: This study revealed that supplementing vitamins C and E to either the triple or quadruple therapies did not provide an additional advantage for achieving significantly higher eradication rates for H. pylori. © Copyright 2015 by The Turkish Society of Gastroenterology.

Yazar Demirci H.
Ilikhan S.U.
Öztürk K.
Üstünda? Y.
Kurt Ö.
Bilici M.
Köktürk F.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/6253
Tek Biçim Adres 10.5152/tjg.2015.0233
Konu Başlıkları Bismuth subcitrate
Eradication rate
Helicobacter pylori
Vitamins E and C
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı Turkish Journal of Gastroenterology
Dergi Cilt Bilgisi 26
Dergi Sayısı 6
Sayfalar 456 - 460
Yayın Yılı 2015
Eser Adı
[dc.title]
Influence of Vitamin C and e supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection
Yazar
[dc.contributor.author]
Demirci H.
Yazar
[dc.contributor.author]
Ilikhan S.U.
Yazar
[dc.contributor.author]
Öztürk K.
Yazar
[dc.contributor.author]
Üstünda? Y.
Yazar
[dc.contributor.author]
Kurt Ö.
Yazar
[dc.contributor.author]
Bilici M.
Yazar
[dc.contributor.author]
Köktürk F.
Yayın Yılı
[dc.date.issued]
2015
Yayıncı
[dc.publisher]
Turkish Society of Gastroenterology
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background/Aims: In our study, we aimed to assess the effect of vitamin E and C supplementation to triple and quadruple Helicobacter pylori eradication regimens. Materials and Methods: Four hundred patients with H. pylori infection were classified into four groups. Patients in group A (n=100) received amoxicillin, clarithromycin, and lansoprazole for 2 weeks. In group B, patients (n=100) received vitamins C and E for a month, in addition to amoxicillin, clarithromycin, and lansoprazole for 2 weeks. Patients in group C (n=100) received amoxicillin, clarithromycin, lansoprazole, and bismuth subcitrate for 2 weeks, whereas those in group D (n=100) received vitamins C and E for a month, in addition to amoxicillin, clarithromycin, lansoprazole, and bismuth subcitrate for 2 weeks. H. pylori eradication was assessed with the C14 urea breath test 2 months after the end of the therapy. The eradication rate was assessed using per-protocol (PP) and intention-to-treat (ITT) analyses. Results: Three hundred forty-eight patients finished the study. The eradication of H. pylori was achieved in 63 of 84 patients (75%) by PP and 63 of 100 (63%) by ITT analysis in group A, 60 of 84 (71.4%) by PP and 60 of 100 (60%) by ITT analysis in group B, 72 of 89 (80.9 %) by PP and 72 of 100 (72%) by ITT analysis in group C, and 76 of 91 (83.5%) by PP and 76 of 100 (76%) by ITT analysis in group D. There was no remarkable change between groups A and B (p>0.05). Similar results were also found between groups D and C (p>0.05). Conclusion: This study revealed that supplementing vitamins C and E to either the triple or quadruple therapies did not provide an additional advantage for achieving significantly higher eradication rates for H. pylori. © Copyright 2015 by The Turkish Society of Gastroenterology.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Bismuth subcitrate
Konu Başlıkları
[dc.subject]
Eradication rate
Konu Başlıkları
[dc.subject]
Helicobacter pylori
Konu Başlıkları
[dc.subject]
Vitamins E and C
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1300-4948
İlk Sayfa Sayısı
[dc.identifier.startpage]
456
Son Sayfa Sayısı
[dc.identifier.endpage]
460
Dergi Adı
[dc.relation.journal]
Turkish Journal of Gastroenterology
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
26
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.5152/tjg.2015.0233
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/6253
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
36
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
17 Nisan 2024 18:56
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Tıklayınız
eradication pylori lansoprazole clarithromycin amoxicillin received (n=100) patients analysis vitamins groups addition bismuth subcitrate between assessed Patients hundred quadruple triple remarkable Copyright Turkish Society Gastroenterology change Similar higher supplementing provide therapies additional either significantly revealed
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