Preventive role of Pycnogenol ® against the hyperglycemia-induced oxidative stress and DNA damage in diabetic rats

Diabetes mellitus, a complex progressive metabolic disorder, leads to some oxidative stress related complications. Pycnogenol ® (PYC), a plant extract obtained from Pinus pinaster, has been suggested to be effective in many diseases including diabetes, cancer, inflammatory and immune system disorders. The mechanisms underlying the effects of PYC in diabetes need to be elucidated. The aim of this study was to determine the effects of PYC treatment (50 mg/kg/day, orally, for 28 days) on the DNA damage and biochemical changes in the blood, liver, and kidney tissues of experimental diabetic rats. Changes in the activities of catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, and glutathione-S-transferase enzymes, and the levels of 8-hydroxy-2'-deoxyguanosine, total glutathione, malondialdehyde, insulin, total bilirubin, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, high density lipoprotein, low density lipoprotein, total cholesterol, and triglyceride were evaluated. DNA damage was also determined in the whole blood cells and the liver and renal tissue cells using the alkaline comet assay. PYC treatment significantly ameliorated the oxidative stress, lipid profile, and liver function parameters as well as DNA damage in the hyperglycemic rats. The results show that PYC treatment might improve the hyperglycemia-induced biochemical and physiological changes in diabetes. © 2018

Yazar Aydın S.
Bacanlı M.
Anlar H.G.
Çal T.
Arı N.
Ündeğer Bucurgat Ü.
Başaran A.A.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/7173
Tek Biçim Adres 10.1016/j.fct.2018.11.038
Konu Başlıkları Diabetes
DNA damage
Hepatic enzymes
Oxidative stress
Pycnogenol
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı Food and Chemical Toxicology
Dergi Cilt Bilgisi 124
Sayfalar 54 - 63
Yayın Yılı 2019
Eser Adı
[dc.title]
Preventive role of Pycnogenol ® against the hyperglycemia-induced oxidative stress and DNA damage in diabetic rats
Yazar
[dc.contributor.author]
Aydın S.
Yazar
[dc.contributor.author]
Bacanlı M.
Yazar
[dc.contributor.author]
Anlar H.G.
Yazar
[dc.contributor.author]
Çal T.
Yazar
[dc.contributor.author]
Arı N.
Yazar
[dc.contributor.author]
Ündeğer Bucurgat Ü.
Yazar
[dc.contributor.author]
Başaran A.A.
Yayın Yılı
[dc.date.issued]
2019
Yayıncı
[dc.publisher]
Elsevier Ltd
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Diabetes mellitus, a complex progressive metabolic disorder, leads to some oxidative stress related complications. Pycnogenol ® (PYC), a plant extract obtained from Pinus pinaster, has been suggested to be effective in many diseases including diabetes, cancer, inflammatory and immune system disorders. The mechanisms underlying the effects of PYC in diabetes need to be elucidated. The aim of this study was to determine the effects of PYC treatment (50 mg/kg/day, orally, for 28 days) on the DNA damage and biochemical changes in the blood, liver, and kidney tissues of experimental diabetic rats. Changes in the activities of catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, and glutathione-S-transferase enzymes, and the levels of 8-hydroxy-2'-deoxyguanosine, total glutathione, malondialdehyde, insulin, total bilirubin, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, high density lipoprotein, low density lipoprotein, total cholesterol, and triglyceride were evaluated. DNA damage was also determined in the whole blood cells and the liver and renal tissue cells using the alkaline comet assay. PYC treatment significantly ameliorated the oxidative stress, lipid profile, and liver function parameters as well as DNA damage in the hyperglycemic rats. The results show that PYC treatment might improve the hyperglycemia-induced biochemical and physiological changes in diabetes. © 2018
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Diabetes
Konu Başlıkları
[dc.subject]
DNA damage
Konu Başlıkları
[dc.subject]
Hepatic enzymes
Konu Başlıkları
[dc.subject]
Oxidative stress
Konu Başlıkları
[dc.subject]
Pycnogenol
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0278-6915
Sponsor YAYINCI
[dc.description.sponsorship]
114S919
Sponsor YAYINCI
[dc.description.sponsorship]
This work was supported by The Scientific and Technological Research Council of Turkey (Grant number: 114S919 ).
İlk Sayfa Sayısı
[dc.identifier.startpage]
54
Son Sayfa Sayısı
[dc.identifier.endpage]
63
Dergi Adı
[dc.relation.journal]
Food and Chemical Toxicology
Dergi Cilt Bilgisi
[dc.identifier.volume]
124
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.fct.2018.11.038
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7173
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
22
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
10 Şubat 2024 01:37
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diabetes glutathione damage treatment aminotransferase density lipoprotein effects biochemical changes stress oxidative alkaline aspartate alanine bilirubin insulin malondialdehyde hyperglycemia-induced improve -deoxyguanosine physiological 8-hydroxy-2 levels enzymes glutathione-S-transferase reductase peroxidase gamma-glutamyl transferase tissue significantly ameliorated determined dismutase
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