Accuracy of the 24-h urine protein excretion value in patients with preeclampsia: correlation with instant and 24-h urine protein/creatinine and albumin/creatinine ratios

The aim of this study was to determine the accuracy of the 24-h urine collection in preeclamptic pregnant women. This study included 65 singletons with preeclampsia and 53 singleton patients in a control-matched group. The ratio of inaccurate 24-h urine collection was measured by calculating expected urine creatinine excretion according to the proportion of pre-pregnancy weight and the lean body mass (LBM) of the patients. Comparisons were made between the accurately-collected 24-h urine protein excretion rates and the instant and 24-h urine protein/creatinine (P/Cr) and albumin/creatinine (A/Cr) ratios. Twenty-four-hour urine collection used to diagnose patients with preeclampsia was incorrectly collected 15–73.5% of the time among the patients and the control group. Instant and 24-h urine P/Cr and A/Cr ratios were correlated with total 24-h proteinuria among the patients in whom urine was collected correctly. Considering the 24-h urine P/Cr ratio, rather than the 24-h urine protein excretion value, is a better way to diagnose preeclampsia.IMPACT STATEMENTWhat is already known on this subject? Twenty-four-hour urine collection is considered as the gold standard of diagnosing proteinuria in preeclampsia, in case of the correctly collected. What do the results of this study add? Generally, in the literature the correctness of 24-h proteinuria is not questioned. However, it is actually quite important in daily practice to make the correct diagnosis of the proteinuria not to misdiagnose preeclampsia. What are the implications of these findings for clinical practice and/or further research? In this article, we aimed to show the importance of accurately collected 24-h urine in preeclampsia. We consider and advise to change the gold standard of this technique to 24-h protein/creatinine (P/Cr) ratio, in order to make correct diagnosis of the preeclampsia. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.

Yazar Doğan S.
Sel G.
Arıkan İ.İ.
Harma M.İ.
Harma M.
Barut A.
Özmen Ü.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/4115
Tek Biçim Adres 10.1080/01443615.2019.1586854
Konu Başlıkları 24-h urine
instant urine
preeclampsia
protein/creatinine
proteinuria
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Journal of Obstetrics and Gynaecology
Dergi Cilt Bilgisi 39
Dergi Sayısı 8
Sayfalar 1075 - 1080
Yayın Yılı 2019
Eser Adı
[dc.title]
Accuracy of the 24-h urine protein excretion value in patients with preeclampsia: correlation with instant and 24-h urine protein/creatinine and albumin/creatinine ratios
Yazar
[dc.contributor.author]
Doğan S.
Yazar
[dc.contributor.author]
Sel G.
Yazar
[dc.contributor.author]
Arıkan İ.İ.
Yazar
[dc.contributor.author]
Harma M.İ.
Yazar
[dc.contributor.author]
Harma M.
Yazar
[dc.contributor.author]
Barut A.
Yazar
[dc.contributor.author]
Özmen Ü.
Yayın Yılı
[dc.date.issued]
2019
Yayıncı
[dc.publisher]
Taylor and Francis Ltd
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
The aim of this study was to determine the accuracy of the 24-h urine collection in preeclamptic pregnant women. This study included 65 singletons with preeclampsia and 53 singleton patients in a control-matched group. The ratio of inaccurate 24-h urine collection was measured by calculating expected urine creatinine excretion according to the proportion of pre-pregnancy weight and the lean body mass (LBM) of the patients. Comparisons were made between the accurately-collected 24-h urine protein excretion rates and the instant and 24-h urine protein/creatinine (P/Cr) and albumin/creatinine (A/Cr) ratios. Twenty-four-hour urine collection used to diagnose patients with preeclampsia was incorrectly collected 15–73.5% of the time among the patients and the control group. Instant and 24-h urine P/Cr and A/Cr ratios were correlated with total 24-h proteinuria among the patients in whom urine was collected correctly. Considering the 24-h urine P/Cr ratio, rather than the 24-h urine protein excretion value, is a better way to diagnose preeclampsia.IMPACT STATEMENTWhat is already known on this subject? Twenty-four-hour urine collection is considered as the gold standard of diagnosing proteinuria in preeclampsia, in case of the correctly collected. What do the results of this study add? Generally, in the literature the correctness of 24-h proteinuria is not questioned. However, it is actually quite important in daily practice to make the correct diagnosis of the proteinuria not to misdiagnose preeclampsia. What are the implications of these findings for clinical practice and/or further research? In this article, we aimed to show the importance of accurately collected 24-h urine in preeclampsia. We consider and advise to change the gold standard of this technique to 24-h protein/creatinine (P/Cr) ratio, in order to make correct diagnosis of the preeclampsia. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
24-h urine
Konu Başlıkları
[dc.subject]
instant urine
Konu Başlıkları
[dc.subject]
preeclampsia
Konu Başlıkları
[dc.subject]
protein/creatinine
Konu Başlıkları
[dc.subject]
proteinuria
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0144-3615
İlk Sayfa Sayısı
[dc.identifier.startpage]
1075
Son Sayfa Sayısı
[dc.identifier.endpage]
1080
Dergi Adı
[dc.relation.journal]
Journal of Obstetrics and Gynaecology
Dergi Sayısı
[dc.identifier.issue]
8
Dergi Cilt Bilgisi
[dc.identifier.volume]
39
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1080/01443615.2019.1586854
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4115
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
17
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 10:16
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Tıklayınız
preeclampsia patients collected proteinuria collection excretion ratios Twenty-four-hour diagnose protein/creatinine correctly (P/Cr) standard practice correct diagnosis protein findings implications misdiagnose preeclamptic pregnant weight clinical important actually However questioned included correctness literature Generally and/or technique Francis
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