Apheresis-inducible cytokine pattern change in children with homozygous familial hypercholesterolemia

Familial hypercholesterolemia is a genetic disorder that leads to severe atherosclerosis related cardiovascular complications in young adults. Extracorporeal elimination is a method of LDL-lowering procedures effective in patients with homozygous or severe heterozygous FH utilized in cases. The recruitment of leucocytes into the arterial intima is dependent on a cascade of events mediated through a diverse family of adhesion molecules. Several pro-inflammatory adhesion molecules are cleared by various lipid apheresis methods. This study showed that, LDL-apheresis led to several changes in circulating inflammatory factors which induced antiinflammatory and antiatherogenic changes in the plasma profile in homozygous familial hypercholesterolemic patients. © 2013 Elsevier Ltd.

Yazar Küçükçongar A.
Yenicesu I.
Tümer L.
Kasapkara C.S.
Ezgü F.S.
Paşaoglu O.
Demirtaş C.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/4322
Tek Biçim Adres 10.1016/j.transci.2013.04.024
Konu Başlıkları Adhesion molecules
Apheresis
Children
Homozygous hypercholesterolemia
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı Transfusion and Apheresis Science
Dergi Cilt Bilgisi 48
Dergi Sayısı 3
Sayfalar 391 - 396
Yayın Yılı 2013
Eser Adı
[dc.title]
Apheresis-inducible cytokine pattern change in children with homozygous familial hypercholesterolemia
Yazar
[dc.contributor.author]
Küçükçongar A.
Yazar
[dc.contributor.author]
Yenicesu I.
Yazar
[dc.contributor.author]
Tümer L.
Yazar
[dc.contributor.author]
Kasapkara C.S.
Yazar
[dc.contributor.author]
Ezgü F.S.
Yazar
[dc.contributor.author]
Paşaoglu O.
Yazar
[dc.contributor.author]
Demirtaş C.
Yayın Yılı
[dc.date.issued]
2013
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Familial hypercholesterolemia is a genetic disorder that leads to severe atherosclerosis related cardiovascular complications in young adults. Extracorporeal elimination is a method of LDL-lowering procedures effective in patients with homozygous or severe heterozygous FH utilized in cases. The recruitment of leucocytes into the arterial intima is dependent on a cascade of events mediated through a diverse family of adhesion molecules. Several pro-inflammatory adhesion molecules are cleared by various lipid apheresis methods. This study showed that, LDL-apheresis led to several changes in circulating inflammatory factors which induced antiinflammatory and antiatherogenic changes in the plasma profile in homozygous familial hypercholesterolemic patients. © 2013 Elsevier Ltd.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Adhesion molecules
Konu Başlıkları
[dc.subject]
Apheresis
Konu Başlıkları
[dc.subject]
Children
Konu Başlıkları
[dc.subject]
Homozygous hypercholesterolemia
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1473-0502
Sponsor YAYINCI
[dc.description.sponsorship]
This study was financially supported by Gazi University .
İlk Sayfa Sayısı
[dc.identifier.startpage]
391
Son Sayfa Sayısı
[dc.identifier.endpage]
396
Dergi Adı
[dc.relation.journal]
Transfusion and Apheresis Science
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
48
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.transci.2013.04.024
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4322
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
7
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 22:20
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Tıklayınız
changes patients adhesion molecules homozygous severe Several LDL-apheresis pro-inflammatory showed cleared methods apheresis various Familial several profile Elsevier hypercholesterolemic familial plasma circulating antiatherogenic antiinflammatory induced inflammatory factors family procedures LDL-lowering method elimination Extracorporeal adults complications
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