Comparison of the effects of bupivacaine, lidocaine, and tramadol infiltration on wound healing in rats

Background and objectives: The aim of this study was to investigate the effects of saline solution, bupivacaine, lidocaine and tramadol infiltration on wound healing in rats. Method: Thirty-two male Wistar Albino rats were randomly separated into four groups, receiving 3. mL saline solution in control group (Group C, n = 8), 3. mL of 2% lidocaine in lidocaine group (Group L, n = 8), 3. mL of 0.5% bupivacaine in bupivacaine group (Group B, n = 8), and 3. mL of 5% tramadol in tramadol group (Group T, n = 8). Breaking-strength measurements, collagen bundle counting, and histopathologic evaluation were evaluated in the tissue samples taken from the rats. Results: Comparing the control group with the groups where bupivacaine and lidocaine were used for wound infiltration, collagen production was lower, breaking-strength measurements showed reduced resistance while significantly high edema, vascularity, inflammation scores were found (p < 0.0125). Between the control and the tramadol group there were no significant differences in collagen production, breaking-strength measurements, and edema, vascularity, inflammation scores (p > 0.0125). Conclusion: In our study, we found bupivacaine and lidocaine reduced the collagen production, wound breaking strength, and caused significantly high scores for edema, vascularity, and inflammation when compared to the control group. There was no significant difference between the control and the tramadol group. Results of this experimental preliminary study on rats support the idea that tramadol can be used for wound infiltration anesthesia without adverse effect on the surgical healing process. These results need to be verified in humans. © 2012 Elsevier Editora Ltda.

Yazar Hanci V.
Hakimoglu S.
Özaçmak H.
Bektaş S.
Özaçmak H.S.
Özdamar T.O.
Yurtlu S.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/4841
Tek Biçim Adres 10.1016/S0034-7094(12)70180-0
Konu Başlıkları Anesthesia, Local
Bupivacaine
Lidocaine
Tramadol
Wound Healing
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı Revista Brasileira de Anestesiologia
Dergi Cilt Bilgisi 62
Dergi Sayısı 6
Sayfalar 799 - 810
Yayın Yılı 2012
Eser Adı
[dc.title]
Comparison of the effects of bupivacaine, lidocaine, and tramadol infiltration on wound healing in rats
Yazar
[dc.contributor.author]
Hanci V.
Yazar
[dc.contributor.author]
Hakimoglu S.
Yazar
[dc.contributor.author]
Özaçmak H.
Yazar
[dc.contributor.author]
Bektaş S.
Yazar
[dc.contributor.author]
Özaçmak H.S.
Yazar
[dc.contributor.author]
Özdamar T.O.
Yazar
[dc.contributor.author]
Yurtlu S.
Yayın Yılı
[dc.date.issued]
2012
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background and objectives: The aim of this study was to investigate the effects of saline solution, bupivacaine, lidocaine and tramadol infiltration on wound healing in rats. Method: Thirty-two male Wistar Albino rats were randomly separated into four groups, receiving 3. mL saline solution in control group (Group C, n = 8), 3. mL of 2% lidocaine in lidocaine group (Group L, n = 8), 3. mL of 0.5% bupivacaine in bupivacaine group (Group B, n = 8), and 3. mL of 5% tramadol in tramadol group (Group T, n = 8). Breaking-strength measurements, collagen bundle counting, and histopathologic evaluation were evaluated in the tissue samples taken from the rats. Results: Comparing the control group with the groups where bupivacaine and lidocaine were used for wound infiltration, collagen production was lower, breaking-strength measurements showed reduced resistance while significantly high edema, vascularity, inflammation scores were found (p < 0.0125). Between the control and the tramadol group there were no significant differences in collagen production, breaking-strength measurements, and edema, vascularity, inflammation scores (p > 0.0125). Conclusion: In our study, we found bupivacaine and lidocaine reduced the collagen production, wound breaking strength, and caused significantly high scores for edema, vascularity, and inflammation when compared to the control group. There was no significant difference between the control and the tramadol group. Results of this experimental preliminary study on rats support the idea that tramadol can be used for wound infiltration anesthesia without adverse effect on the surgical healing process. These results need to be verified in humans. © 2012 Elsevier Editora Ltda.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Anesthesia, Local
Konu Başlıkları
[dc.subject]
Bupivacaine
Konu Başlıkları
[dc.subject]
Lidocaine
Konu Başlıkları
[dc.subject]
Tramadol
Konu Başlıkları
[dc.subject]
Wound Healing
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0034-7094
İlk Sayfa Sayısı
[dc.identifier.startpage]
799
Son Sayfa Sayısı
[dc.identifier.endpage]
810
Dergi Adı
[dc.relation.journal]
Revista Brasileira de Anestesiologia
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
62
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/S0034-7094(12)70180-0
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4841
Görüntülenme Sayısı ( Şehir )
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Görüntülenme
27
09.12.2022 tarihinden bu yana
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1
09.12.2022 tarihinden bu yana
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09 Şubat 2024 07:55
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tramadol lidocaine bupivacaine control (Group collagen inflammation scores measurements infiltration production vascularity breaking-strength reduced significantly significant Results healing saline solution groups adverse verified Conclusion humans differences results without Elsevier Editora difference support effect surgical preliminary
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