Protective Value of a Folkloric Medicinal Plant Extract Against Mortality and Hemorrhage in a Life-threatening Renal Trauma Model

Objectives: To compare the efficacy of a folkloric medicinal plant extract (Ankaferd Blood Stopper [ABS]) with that of oxidized cellulose (Surgicel) in a life-threatening renal injury model. ABS is a mixture of 5 plants that has historically been used in Turkish traditional medicine. It has been approved by the Ministry of Health to manage external hemorrhage and dental surgery bleeding in Turkey. Methods: Twenty-two Wistar albino rats underwent partial nephrectomy after intravenous heparin anticoagulation (2000 U/kg). The cut surface received 1 of 3 therapies, namely no treatment, Surgicel (Johnson & Johnson, New Brunswick, NJ) or ABS (Trend Teknoloji İaç AŞ, Istanbul, Turkey). Blood pressure was continually monitored. Survival time, total blood loss, and mean arterial pressure were recorded for 60 minute or until death. Rats that were alive (mean arterial pressure ?20 mm Hg) at the end of 60 minutes were sacrificed with blood withdrawal with the help of catheters. Results: All animals that received no treatment died within 60 minutes of follow-up. One of 7 in the Surgicel group, and 5 of 7 animals in the ABS group, survived. Mean survival times for the Surgicel and ABS groups were 42.7 and 53.4 minutes, respectively. Rats in the ABS and Surgicel groups survived significantly longer than rats in the control group (P <.05). There were no significant differences between the ABS and the Surgicel groups in survival (P = .128). Conclusions: ABS is as effective as Surgicel in achieving hemostasis and lengthening survival time following partial nephrectomy in an experimental rat model. © 2010 Elsevier Inc. All rights reserved.

Yazar Tokgöz H.
Karakaya K.
Hanci V.
Abduşoglu M.
Erol B.
Türksoy Ö.
Akduman B.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/7241
Tek Biçim Adres 10.1016/j.urology.2009.12.016
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Urology
Dergi Cilt Bilgisi 75
Dergi Sayısı 6
Sayfalar 1.52E+12 - 1.52E+17
Yayın Yılı 2010
Eser Adı
[dc.title]
Protective Value of a Folkloric Medicinal Plant Extract Against Mortality and Hemorrhage in a Life-threatening Renal Trauma Model
Yazar
[dc.contributor.author]
Tokgöz H.
Yazar
[dc.contributor.author]
Karakaya K.
Yazar
[dc.contributor.author]
Hanci V.
Yazar
[dc.contributor.author]
Abduşoglu M.
Yazar
[dc.contributor.author]
Erol B.
Yazar
[dc.contributor.author]
Türksoy Ö.
Yazar
[dc.contributor.author]
Akduman B.
Yayın Yılı
[dc.date.issued]
2010
Yayıncı
[dc.publisher]
Elsevier Inc.
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objectives: To compare the efficacy of a folkloric medicinal plant extract (Ankaferd Blood Stopper [ABS]) with that of oxidized cellulose (Surgicel) in a life-threatening renal injury model. ABS is a mixture of 5 plants that has historically been used in Turkish traditional medicine. It has been approved by the Ministry of Health to manage external hemorrhage and dental surgery bleeding in Turkey. Methods: Twenty-two Wistar albino rats underwent partial nephrectomy after intravenous heparin anticoagulation (2000 U/kg). The cut surface received 1 of 3 therapies, namely no treatment, Surgicel (Johnson & Johnson, New Brunswick, NJ) or ABS (Trend Teknoloji İaç AŞ, Istanbul, Turkey). Blood pressure was continually monitored. Survival time, total blood loss, and mean arterial pressure were recorded for 60 minute or until death. Rats that were alive (mean arterial pressure ?20 mm Hg) at the end of 60 minutes were sacrificed with blood withdrawal with the help of catheters. Results: All animals that received no treatment died within 60 minutes of follow-up. One of 7 in the Surgicel group, and 5 of 7 animals in the ABS group, survived. Mean survival times for the Surgicel and ABS groups were 42.7 and 53.4 minutes, respectively. Rats in the ABS and Surgicel groups survived significantly longer than rats in the control group (P <.05). There were no significant differences between the ABS and the Surgicel groups in survival (P = .128). Conclusions: ABS is as effective as Surgicel in achieving hemostasis and lengthening survival time following partial nephrectomy in an experimental rat model. © 2010 Elsevier Inc. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0090-4295
İlk Sayfa Sayısı
[dc.identifier.startpage]
1.52E+12
Son Sayfa Sayısı
[dc.identifier.endpage]
1.52E+17
Dergi Adı
[dc.relation.journal]
Urology
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
75
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.urology.2009.12.016
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7241
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
26
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
10 Şubat 2024 00:50
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Surgicel pressure survival minutes groups nephrectomy treatment survived animals arterial partial received Results catheters Objectives withdrawal sacrificed minute recorded within experimental effective achieving hemostasis lengthening following Elsevier rights reserved Conclusions follow-up significantly respectively longer between
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