Promoter polymorphisms of IL18 gene in chronic hepatitis C patients [Kronik hepatit C hastalarinda IL18 promotor bölge polimorfizmi]

Objective: Chronic HCV infection is a dynamic state of the interactions between virus and host immune response, and the natural course varies greatly among different individuals. So currently, most studies investigating the underlying mechanisms of HCV infection have focused on genetic variations in the human population. Specially, polymorphisms of immune response genes may be considered related to a genetic susceptibility to HCV infection. IL18 is a proinflammatory cytokine that plays an important role in the Th1 response. IL18 gene has two polymorphisms (-137 G/C and -607 A/C) within the promoter of the gene have been associated with different inflammatory and autoimmune diseases. However, there are a few study whether IL18 polymorphisms have influence on host immune response to HCV infection. The aim of the present study was to determine whether IL18 promoter polymorphisms association with chronic HCV infection in Turkish subjects. Method: To evaluate the role of host IL18 -607C/A (rs1946518) and -137G/C (rs187238) polymorphism in predicting HCV infection, IL18 gene polymorphisms were studied in 63 hepatitis C patients and 65 control subjects by using the PCR-RFLP method. Results: No significant differences were observed in genotype or allele frequencies among chronically HCV-infected and healthy subjects. Conclusion: Our results suggest that the IL18 gene polymorphism is not a major factor predisposing to the development of chronic Hepatitis C infection. ©Copyright 2014 by Gazi University Medical Faculty

Yazar Karakaş-Çelik S.
Börekçi G.
Kandemir Ö.
Yalin S.
Berköz M.
Bekalp I.
Kubilay A.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/7214
Tek Biçim Adres 10.12996/gmj.2014.39
Konu Başlıkları HCV
Hepatitis C
IL18
Interleukin 18
Polymorphism
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı Gazi Medical Journal
Dergi Cilt Bilgisi 25
Dergi Sayısı 4
Sayfalar 125 - 127
Yayın Yılı 2014
Eser Adı
[dc.title]
Promoter polymorphisms of IL18 gene in chronic hepatitis C patients [Kronik hepatit C hastalarinda IL18 promotor bölge polimorfizmi]
Yazar
[dc.contributor.author]
Karakaş-Çelik S.
Yazar
[dc.contributor.author]
Börekçi G.
Yazar
[dc.contributor.author]
Kandemir Ö.
Yazar
[dc.contributor.author]
Yalin S.
Yazar
[dc.contributor.author]
Berköz M.
Yazar
[dc.contributor.author]
Bekalp I.
Yazar
[dc.contributor.author]
Kubilay A.
Yayın Yılı
[dc.date.issued]
2014
Yayıncı
[dc.publisher]
Gazi Universitesi
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: Chronic HCV infection is a dynamic state of the interactions between virus and host immune response, and the natural course varies greatly among different individuals. So currently, most studies investigating the underlying mechanisms of HCV infection have focused on genetic variations in the human population. Specially, polymorphisms of immune response genes may be considered related to a genetic susceptibility to HCV infection. IL18 is a proinflammatory cytokine that plays an important role in the Th1 response. IL18 gene has two polymorphisms (-137 G/C and -607 A/C) within the promoter of the gene have been associated with different inflammatory and autoimmune diseases. However, there are a few study whether IL18 polymorphisms have influence on host immune response to HCV infection. The aim of the present study was to determine whether IL18 promoter polymorphisms association with chronic HCV infection in Turkish subjects. Method: To evaluate the role of host IL18 -607C/A (rs1946518) and -137G/C (rs187238) polymorphism in predicting HCV infection, IL18 gene polymorphisms were studied in 63 hepatitis C patients and 65 control subjects by using the PCR-RFLP method. Results: No significant differences were observed in genotype or allele frequencies among chronically HCV-infected and healthy subjects. Conclusion: Our results suggest that the IL18 gene polymorphism is not a major factor predisposing to the development of chronic Hepatitis C infection. ©Copyright 2014 by Gazi University Medical Faculty
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
tur
Konu Başlıkları
[dc.subject]
HCV
Konu Başlıkları
[dc.subject]
Hepatitis C
Konu Başlıkları
[dc.subject]
IL18
Konu Başlıkları
[dc.subject]
Interleukin 18
Konu Başlıkları
[dc.subject]
Polymorphism
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
2147-2092
İlk Sayfa Sayısı
[dc.identifier.startpage]
125
Son Sayfa Sayısı
[dc.identifier.endpage]
127
Dergi Adı
[dc.relation.journal]
Gazi Medical Journal
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
25
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.12996/gmj.2014.39
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7214
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
51
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 09:57
Google Kontrol
Tıklayınız
infection polymorphisms response immune subjects promoter genetic polymorphism whether different chronic Turkish association control patients -137G/C Method (rs187238) evaluate -607C/A studied predicting (rs1946518) hepatitis observed Medical University ©Copyright Hepatitis development predisposing factor suggest results Conclusion
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms