Antioxidative and immunomodulatory effects of A-lipoic acid in rat colitis model induced by acetic acid

Aim: Benefit of ?-Lipoic acid (ALA) was previously shown in rat-colitis model via suppression of neutrophil accumulation, preservation of endogenous glutathione and inhibition of reactive oxidant generation. Ulcerative colitis is a chronic inflammatory condition of the colon and cytokines (such as TNF-?, IL-1ß and TGF-ß) are crucial components of these inflammatory pathways. Hence, the present study was undertaken to evaluate the antioxidative and immunomodulatory effects of ALA on experimental colitis model induced by acetic acid in Wistar albino rats. Methods: Mice received either a control diet or ALA-supplemented diet for 14 d. Colitis was induced by acetic acid administration at 7th day. Mucosal damage and the activation of immune cells and cytokines were determined by macroscopic score, histological score, tissue cytokine levels (TNF-?, IL-1ß and TGF-ß). Anti-oxidant effect of ALA was determined by Malondialdehyde, and total antioxidative status. Results: Disease activity Index was significantly higher in colitis group compared to control, ALA and ALA-colitis groups (p<0.001). No significant difference was found between DAI of control, ALA and ALA-colitis groups. The inflammatory mediators, TNF-? and IL-1ß, and MDA were elevated in colitis group compared to other groups (p<0.001, p<0.001 respectively). TGF-ß and total antioxidative status were significantly lower in colitis group (p<0.001). Conclusion: ALA may possibly have some therapeutic usefulness in the management of ulcerative colitis. ©Copyright 2019 by Gazi University Medical Faculty - Available on-line at web site http://medicaljournal.gazi.edu.tr/

Yazar Ergül B.
Doğan Z.
Sarıkaya M.
Filik L.
Utku Ö.G.
Gönültaş M.
Hücümenoğlu S.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/4315
Tek Biçim Adres 10.12996/gmj.2019.33
Konu Başlıkları Antioxidative effect
IL-1ß
MDA
TAS
TGF-ß
TNF-?
Ulcerative colitis
?-Lipoic acid
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Gazi Medical Journal
Dergi Cilt Bilgisi 30
Dergi Sayısı 2
Sayfalar 125 - 129
Yayın Yılı 2019
Eser Adı
[dc.title]
Antioxidative and immunomodulatory effects of A-lipoic acid in rat colitis model induced by acetic acid
Yazar
[dc.contributor.author]
Ergül B.
Yazar
[dc.contributor.author]
Doğan Z.
Yazar
[dc.contributor.author]
Sarıkaya M.
Yazar
[dc.contributor.author]
Filik L.
Yazar
[dc.contributor.author]
Utku Ö.G.
Yazar
[dc.contributor.author]
Gönültaş M.
Yazar
[dc.contributor.author]
Hücümenoğlu S.
Yayın Yılı
[dc.date.issued]
2019
Yayıncı
[dc.publisher]
Gazi Universitesi
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Aim: Benefit of ?-Lipoic acid (ALA) was previously shown in rat-colitis model via suppression of neutrophil accumulation, preservation of endogenous glutathione and inhibition of reactive oxidant generation. Ulcerative colitis is a chronic inflammatory condition of the colon and cytokines (such as TNF-?, IL-1ß and TGF-ß) are crucial components of these inflammatory pathways. Hence, the present study was undertaken to evaluate the antioxidative and immunomodulatory effects of ALA on experimental colitis model induced by acetic acid in Wistar albino rats. Methods: Mice received either a control diet or ALA-supplemented diet for 14 d. Colitis was induced by acetic acid administration at 7th day. Mucosal damage and the activation of immune cells and cytokines were determined by macroscopic score, histological score, tissue cytokine levels (TNF-?, IL-1ß and TGF-ß). Anti-oxidant effect of ALA was determined by Malondialdehyde, and total antioxidative status. Results: Disease activity Index was significantly higher in colitis group compared to control, ALA and ALA-colitis groups (p<0.001). No significant difference was found between DAI of control, ALA and ALA-colitis groups. The inflammatory mediators, TNF-? and IL-1ß, and MDA were elevated in colitis group compared to other groups (p<0.001, p<0.001 respectively). TGF-ß and total antioxidative status were significantly lower in colitis group (p<0.001). Conclusion: ALA may possibly have some therapeutic usefulness in the management of ulcerative colitis. ©Copyright 2019 by Gazi University Medical Faculty - Available on-line at web site http://medicaljournal.gazi.edu.tr/
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Antioxidative effect
Konu Başlıkları
[dc.subject]
IL-1ß
Konu Başlıkları
[dc.subject]
MDA
Konu Başlıkları
[dc.subject]
TAS
Konu Başlıkları
[dc.subject]
TGF-ß
Konu Başlıkları
[dc.subject]
TNF-?
Konu Başlıkları
[dc.subject]
Ulcerative colitis
Konu Başlıkları
[dc.subject]
?-Lipoic acid
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
2147-2092
İlk Sayfa Sayısı
[dc.identifier.startpage]
125
Son Sayfa Sayısı
[dc.identifier.endpage]
129
Dergi Adı
[dc.relation.journal]
Gazi Medical Journal
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
30
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.12996/gmj.2019.33
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4315
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
29
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
21 Şubat 2024 00:56
Google Kontrol
Tıklayınız
colitis IL-1ß groups antioxidative inflammatory control TGF-ß) //medicaljournal cytokines determined ALA-colitis compared acetic significantly status induced between effect Disease difference significant activity Malondialdehyde higher Results respectively) ©Copyright target="_blank">http href="http on-line Available Faculty Medical University ulcerative
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms