A novel preoperative scoring system for predicting endometrial cancer in patients with complex atypical endometrial hyperplasia and accuracy of frozen section pathological examination in this context: A multicenter study

Objective: To estimate the accuracy of frozen pathological analysis in patients preoperatively diagnosed with endometrial atypical complex hyperplasia (ACH) and to develop a model predicting the probability of the presence of endometrial carcinoma in ACH. Methods: Patients (n = 128) who underwent total hysterectomies because of diagnoses of ACH were evaluated at four tertiary centers. Results: Diagnoses made using frozen sections and permanent sections were in good agreement (k = 0.61, p < 0.0001). A useful scoring system combining weighted risk factors derived from a regression model is as follows: (2 × age ?50 years) + (3 × BMI ?30) + (2 × menopausal status) + (2 × diabetes comorbidity) + (3 × endometrial thickness >12 mm). The AUC of this score was 0.793, and the score afforded 80.9% sensitivity, 70.3% specificity, a 75.3% positive predictive value, and a 76.4% negative predictive value, when a score of 5 was used as a cutoff. Conclusions: Patients with ACH should be evaluated by gynecological oncologists and intraoperative frozen section analysis should be performed by pathologists specializing in the evaluation of gynecological malignancies, because ACH is closely associated with endometrial cancer (EC). Our novel preoperative scoring system may aid in the detection of patients at increased risk of EC and thus guide general gynecologists. © 2014 S. Karger AG, Basel.

Yazar Gungorduk K.
Ozdemir A.
Ertas I.E.
Sahbaz A.
Asicioglu O.
Gokcu M.
Solmaz U.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/4005
Tek Biçim Adres 10.1159/000365086
Konu Başlıkları Endometrial atypical complex hyperplasia
Endometrial carcinoma
Frozen section
Preoperative scoring system
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Gynecologic and Obstetric Investigation
Dergi Cilt Bilgisi 79
Dergi Sayısı 1
Sayfalar 50 - 56
Yayın Yılı 2015
Eser Adı
[dc.title]
A novel preoperative scoring system for predicting endometrial cancer in patients with complex atypical endometrial hyperplasia and accuracy of frozen section pathological examination in this context: A multicenter study
Yazar
[dc.contributor.author]
Gungorduk K.
Yazar
[dc.contributor.author]
Ozdemir A.
Yazar
[dc.contributor.author]
Ertas I.E.
Yazar
[dc.contributor.author]
Sahbaz A.
Yazar
[dc.contributor.author]
Asicioglu O.
Yazar
[dc.contributor.author]
Gokcu M.
Yazar
[dc.contributor.author]
Solmaz U.
Yayın Yılı
[dc.date.issued]
2015
Yayıncı
[dc.publisher]
S. Karger AG
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: To estimate the accuracy of frozen pathological analysis in patients preoperatively diagnosed with endometrial atypical complex hyperplasia (ACH) and to develop a model predicting the probability of the presence of endometrial carcinoma in ACH. Methods: Patients (n = 128) who underwent total hysterectomies because of diagnoses of ACH were evaluated at four tertiary centers. Results: Diagnoses made using frozen sections and permanent sections were in good agreement (k = 0.61, p < 0.0001). A useful scoring system combining weighted risk factors derived from a regression model is as follows: (2 × age ?50 years) + (3 × BMI ?30) + (2 × menopausal status) + (2 × diabetes comorbidity) + (3 × endometrial thickness >12 mm). The AUC of this score was 0.793, and the score afforded 80.9% sensitivity, 70.3% specificity, a 75.3% positive predictive value, and a 76.4% negative predictive value, when a score of 5 was used as a cutoff. Conclusions: Patients with ACH should be evaluated by gynecological oncologists and intraoperative frozen section analysis should be performed by pathologists specializing in the evaluation of gynecological malignancies, because ACH is closely associated with endometrial cancer (EC). Our novel preoperative scoring system may aid in the detection of patients at increased risk of EC and thus guide general gynecologists. © 2014 S. Karger AG, Basel.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Endometrial atypical complex hyperplasia
Konu Başlıkları
[dc.subject]
Endometrial carcinoma
Konu Başlıkları
[dc.subject]
Frozen section
Konu Başlıkları
[dc.subject]
Preoperative scoring system
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0378-7346
İlk Sayfa Sayısı
[dc.identifier.startpage]
50
Son Sayfa Sayısı
[dc.identifier.endpage]
56
Dergi Adı
[dc.relation.journal]
Gynecologic and Obstetric Investigation
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
79
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1159/000365086
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4005
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
5
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
07 Nisan 2024 18:29
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Tıklayınız
endometrial frozen evaluated system gynecological because should predictive scoring sections Patients analysis patients negative afforded sensitivity positive specificity cutoff specializing Conclusions Karger gynecologists general increased detection oncologists preoperative cancer associated closely malignancies evaluation pathologists performed
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