Gender disparities in heart failure with mid-range and preserved ejection fraction: Results from APOLLON study

Objective: This study aimed to examine gender-based differences in epidemiology, clinical characteristics, and management of consecutive patients with heart failure with mid-range ejection fraction (HFmrEF) and heart failure with preserved ejection fraction (HFpEF). Methods: The APOLLON trial (A comPrehensive, ObservationaL registry of heart faiLure with mid-range and preserved ejection fractiON) is a multicenter, cross-sectional, and observational study. Consecutive patients with HFmrEF or HFpEF who were admitted to the cardiology clinics were included (NCT03026114). Herein, we performed a post-hoc analysis of data from the APOLLON trial. Results: The study population included 1065 (mean age of 67.1±10.6 years, 54% women) patients from 11 sites in Turkey. Compared with men, women were older (68 years vs. 67 years, p<0.001), had higher body mass index (29 kg/m2 vs. 27 kg/m2, p<0.001), and had higher heart rate (80 bpm vs. 77.5 bpm, p<0.001). Women were more likely to have HFpEF (82% vs. 70.9%, p<0.001), and they differ from men having a higher prevalence of hypertension (78.7% vs. 73.2%, p=0.035) and atrial fibrillation (40.7% vs. 29.9%, p<0.001) but lower prevalence of coronary artery disease (29.5% vs. 54.9%, p<0.001). Women had higher N-terminal pro-B-type natriuretic peptide (691 pg/mL vs. 541 pg/mL, p=0.004), lower hemoglobin (12.7 g/dL vs. 13.8 g/dL, p<0.001), and serum ferritin (51 ng/mL vs. 64 ng/mL, p=0.001) levels, and they had worse diastolic function (E/e’=10 vs. 9, p<0.001). The main cause of heart failure (HF) in women was atrial fibrillation, while it was ischemic heart disease in men. Conclusion: Clinical characteristics, laboratory findings, and etiological factors are significantly different in female and male patients with HFmrEF and HFpEF. This study offers a broad perspective for increased awareness about this patient profile in Turkey. (Anatol J Cardiol 2019; 21: 242-52). © Copyright 2019 by Turkish Society of Cardiology.

Yazar Özlek B.
Özlek E.
Kahraman S.
Tekinalp M.
Ağuş H.Z.
Çelik O.
Çil C.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/5963
Tek Biçim Adres 10.14744/AnatolJCardiol.2019.71954
Konu Başlıkları Clinical features
Differences
Gender
Heart failure with mid-range ejection fraction
Heart failure with preserved ejection fraction
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
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Dergi Adı Anatolian Journal of Cardiology
Dergi Cilt Bilgisi 21
Dergi Sayısı 5
Sayfalar 242 - 252
Yayın Yılı 2019
Eser Adı
[dc.title]
Gender disparities in heart failure with mid-range and preserved ejection fraction: Results from APOLLON study
Yazar
[dc.contributor.author]
Özlek B.
Yazar
[dc.contributor.author]
Özlek E.
Yazar
[dc.contributor.author]
Kahraman S.
Yazar
[dc.contributor.author]
Tekinalp M.
Yazar
[dc.contributor.author]
Ağuş H.Z.
Yazar
[dc.contributor.author]
Çelik O.
Yazar
[dc.contributor.author]
Çil C.
Yayın Yılı
[dc.date.issued]
2019
Yayıncı
[dc.publisher]
Turkish Society of Cardiology
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: This study aimed to examine gender-based differences in epidemiology, clinical characteristics, and management of consecutive patients with heart failure with mid-range ejection fraction (HFmrEF) and heart failure with preserved ejection fraction (HFpEF). Methods: The APOLLON trial (A comPrehensive, ObservationaL registry of heart faiLure with mid-range and preserved ejection fractiON) is a multicenter, cross-sectional, and observational study. Consecutive patients with HFmrEF or HFpEF who were admitted to the cardiology clinics were included (NCT03026114). Herein, we performed a post-hoc analysis of data from the APOLLON trial. Results: The study population included 1065 (mean age of 67.1±10.6 years, 54% women) patients from 11 sites in Turkey. Compared with men, women were older (68 years vs. 67 years, p<0.001), had higher body mass index (29 kg/m2 vs. 27 kg/m2, p<0.001), and had higher heart rate (80 bpm vs. 77.5 bpm, p<0.001). Women were more likely to have HFpEF (82% vs. 70.9%, p<0.001), and they differ from men having a higher prevalence of hypertension (78.7% vs. 73.2%, p=0.035) and atrial fibrillation (40.7% vs. 29.9%, p<0.001) but lower prevalence of coronary artery disease (29.5% vs. 54.9%, p<0.001). Women had higher N-terminal pro-B-type natriuretic peptide (691 pg/mL vs. 541 pg/mL, p=0.004), lower hemoglobin (12.7 g/dL vs. 13.8 g/dL, p<0.001), and serum ferritin (51 ng/mL vs. 64 ng/mL, p=0.001) levels, and they had worse diastolic function (E/e’=10 vs. 9, p<0.001). The main cause of heart failure (HF) in women was atrial fibrillation, while it was ischemic heart disease in men. Conclusion: Clinical characteristics, laboratory findings, and etiological factors are significantly different in female and male patients with HFmrEF and HFpEF. This study offers a broad perspective for increased awareness about this patient profile in Turkey. (Anatol J Cardiol 2019; 21: 242-52). © Copyright 2019 by Turkish Society of Cardiology.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Clinical features
Konu Başlıkları
[dc.subject]
Differences
Konu Başlıkları
[dc.subject]
Gender
Konu Başlıkları
[dc.subject]
Heart failure with mid-range ejection fraction
Konu Başlıkları
[dc.subject]
Heart failure with preserved ejection fraction
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
2149-2263
İlk Sayfa Sayısı
[dc.identifier.startpage]
242
Son Sayfa Sayısı
[dc.identifier.endpage]
252
Dergi Adı
[dc.relation.journal]
Anatolian Journal of Cardiology
Dergi Sayısı
[dc.identifier.issue]
5
Dergi Cilt Bilgisi
[dc.identifier.volume]
21
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.14744/AnatolJCardiol.2019.71954
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5963
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
12
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
06 Şubat 2024 18:24
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Tıklayınız
higher patients ejection failure fraction included characteristics fibrillation disease atrial HFmrEF preserved Turkey mid-range APOLLON prevalence artery pro-B-type natriuretic peptide ferritin N-terminal hemoglobin Objective levels (Anatol perspective increased awareness patient profile offers Cardiol 242-52) Copyright
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