Prognostic importance of Ki-67 labeling index in grade II glial tumors

OBJECTIVE To date, several methods have been identified for predicting the prognostic subgroups of grade II gliomas; however, these methods have some limitations in predicting survival. So, we aimed to determine the predictive role of Ki-67 labeling index (LI) on survival. METHODS Between 1995 and 2014, patients with grade II gliomas were retrospectively analyzed. All patients received radiotherapy (RT). RESULTS This study included 78 patients with median 44 (range, 6–137) months follow-up. Patients aged ?40 years had a poorer overall survival (OS) than those aged <40 years (p=0.04). Patients with gross total resection/ subtotal resection had a longer OS than those with biopsy/partial resection (p=0.001). If the disease had recurrence or progression during the follow-up period, the patients had a poorer OS (p=0.01). Patients with a Ki-67 LI ?4% had a poorer OS than those with Ki-67 LI < 4% (p=0.001). The extent of resection, recurrence, or progression, and Ki-67 ?4% were the independent prognostic factors for OS. CONCLUSION In our opinion, Ki-67 LI is an important prognostic factor for grade II gliomas, but it cannot be used as a diagnostic measure alone. It must be used in combination with the other prognostic factors. © 2018, Turkish Society for Radiation Oncology.

Yazar Kanyilmaz G.
Önder H.
Aktan M.
Koç M.
Bora H.
Karahacioğlu E.
Erkal H.Ş.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/7203
Tek Biçim Adres 10.5505/tjo.2018.1752
Konu Başlıkları Grade II glial tumors
Ki-67 labeling index
Prognostic factors
Radiotherapy
Survival
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Turk Onkoloji Dergisi
Dergi Cilt Bilgisi 33
Dergi Sayısı 2
Sayfalar 48 - 53
Yayın Yılı 2018
Eser Adı
[dc.title]
Prognostic importance of Ki-67 labeling index in grade II glial tumors
Yazar
[dc.contributor.author]
Kanyilmaz G.
Yazar
[dc.contributor.author]
Önder H.
Yazar
[dc.contributor.author]
Aktan M.
Yazar
[dc.contributor.author]
Koç M.
Yazar
[dc.contributor.author]
Bora H.
Yazar
[dc.contributor.author]
Karahacioğlu E.
Yazar
[dc.contributor.author]
Erkal H.Ş.
Yayın Yılı
[dc.date.issued]
2018
Yayıncı
[dc.publisher]
Istanbul Tip Fakultesi
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
OBJECTIVE To date, several methods have been identified for predicting the prognostic subgroups of grade II gliomas; however, these methods have some limitations in predicting survival. So, we aimed to determine the predictive role of Ki-67 labeling index (LI) on survival. METHODS Between 1995 and 2014, patients with grade II gliomas were retrospectively analyzed. All patients received radiotherapy (RT). RESULTS This study included 78 patients with median 44 (range, 6–137) months follow-up. Patients aged ?40 years had a poorer overall survival (OS) than those aged <40 years (p=0.04). Patients with gross total resection/ subtotal resection had a longer OS than those with biopsy/partial resection (p=0.001). If the disease had recurrence or progression during the follow-up period, the patients had a poorer OS (p=0.01). Patients with a Ki-67 LI ?4% had a poorer OS than those with Ki-67 LI < 4% (p=0.001). The extent of resection, recurrence, or progression, and Ki-67 ?4% were the independent prognostic factors for OS. CONCLUSION In our opinion, Ki-67 LI is an important prognostic factor for grade II gliomas, but it cannot be used as a diagnostic measure alone. It must be used in combination with the other prognostic factors. © 2018, Turkish Society for Radiation Oncology.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Grade II glial tumors
Konu Başlıkları
[dc.subject]
Ki-67 labeling index
Konu Başlıkları
[dc.subject]
Prognostic factors
Konu Başlıkları
[dc.subject]
Radiotherapy
Konu Başlıkları
[dc.subject]
Survival
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1300-7467
İlk Sayfa Sayısı
[dc.identifier.startpage]
48
Son Sayfa Sayısı
[dc.identifier.endpage]
53
Dergi Adı
[dc.relation.journal]
Turk Onkoloji Dergisi
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
33
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.5505/tjo.2018.1752
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7203
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
28
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
07 Şubat 2024 20:43
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patients prognostic gliomas survival Patients resection poorer recurrence follow-up progression factors predicting methods combination disease Turkish during Society biopsy/partial Radiation Oncology longer period factor important subtotal cannot opinion CONCLUSION diagnostic independent extent measure OBJECTIVE resection/
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