Effect of timing of glutamine-enriched enteral nutrition on intestinal damage caused by irradiation

Intestinal mucosal damage and bacterial translocation are clinical problems that may be caused by the use of ionizing radiation. Glutamine (Gln) support reduces the mucosal barrier in several ways. This study was undertaken to investigate the effect of timing of Gln-enriched enteral nutrition (EN) on bacterial translocation and mucosal damage due to radiotherapy (RT). A rat model of whole body irradiation was designed in which a single dose of 485 cGy was given. A total of 50 rats were randomly assigned to the following 5 groups, each of which comprised 10 rats: (1) balanced rat chow given for 8 days without RT (group 1); (2) balanced rat chow given 4 days before and 4 days after RT (group 2); (3) Gln-enriched EN given 4 days before RT (group 3); (4) Gln-enriched EN given 4 days after RT (group 4); and (5) Gln-enriched EN given 4 days before and 4 days after RT (group 5). Mesenteric lymph node and ileum samples were removed for evaluation of bacterial translocation (BT) and histopathologic investigation, respectively. BT and intestinal mucosal injury scores in all rats that received RT were higher than in rats without RT. No difference was seen in parameters between groups 3 and 4 (P>.05, P>.016, respectively); BT and intestinal mucosal injury scores of group 5 were significantly lower than those of groups 3 and 4 (P<,05, P<.016, respectively). Meanwhile, the BT and mesenteric injury scores of group 5 were significantly lower than those of group 2 (P<.05, P<.016, respectively). As a result, intestinal injury due to RT was significantly decreased by Gln-enriched EN support given before and after whole body RT. ©2007 Health Communications Inc.

Yazar Salman B.
Oguz M.
Akmansu M.
Bebitoglu I.
Akca G.
Sultan N.
Emre U.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/5397
Tek Biçim Adres 10.1007/BF02848790
Konu Başlıkları Enteral nutrition
Glutamine
Intestinal damage
Irradiation
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Advances in Therapy
Dergi Cilt Bilgisi 24
Dergi Sayısı 3
Sayfalar 648 - 661
Yayın Yılı 2007
Eser Adı
[dc.title]
Effect of timing of glutamine-enriched enteral nutrition on intestinal damage caused by irradiation
Yazar
[dc.contributor.author]
Salman B.
Yazar
[dc.contributor.author]
Oguz M.
Yazar
[dc.contributor.author]
Akmansu M.
Yazar
[dc.contributor.author]
Bebitoglu I.
Yazar
[dc.contributor.author]
Akca G.
Yazar
[dc.contributor.author]
Sultan N.
Yazar
[dc.contributor.author]
Emre U.
Yayın Yılı
[dc.date.issued]
2007
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Intestinal mucosal damage and bacterial translocation are clinical problems that may be caused by the use of ionizing radiation. Glutamine (Gln) support reduces the mucosal barrier in several ways. This study was undertaken to investigate the effect of timing of Gln-enriched enteral nutrition (EN) on bacterial translocation and mucosal damage due to radiotherapy (RT). A rat model of whole body irradiation was designed in which a single dose of 485 cGy was given. A total of 50 rats were randomly assigned to the following 5 groups, each of which comprised 10 rats: (1) balanced rat chow given for 8 days without RT (group 1); (2) balanced rat chow given 4 days before and 4 days after RT (group 2); (3) Gln-enriched EN given 4 days before RT (group 3); (4) Gln-enriched EN given 4 days after RT (group 4); and (5) Gln-enriched EN given 4 days before and 4 days after RT (group 5). Mesenteric lymph node and ileum samples were removed for evaluation of bacterial translocation (BT) and histopathologic investigation, respectively. BT and intestinal mucosal injury scores in all rats that received RT were higher than in rats without RT. No difference was seen in parameters between groups 3 and 4 (P>.05, P>.016, respectively); BT and intestinal mucosal injury scores of group 5 were significantly lower than those of groups 3 and 4 (P<,05, P<.016, respectively). Meanwhile, the BT and mesenteric injury scores of group 5 were significantly lower than those of group 2 (P<.05, P<.016, respectively). As a result, intestinal injury due to RT was significantly decreased by Gln-enriched EN support given before and after whole body RT. ©2007 Health Communications Inc.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Enteral nutrition
Konu Başlıkları
[dc.subject]
Glutamine
Konu Başlıkları
[dc.subject]
Intestinal damage
Konu Başlıkları
[dc.subject]
Irradiation
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0741238X
İlk Sayfa Sayısı
[dc.identifier.startpage]
648
Son Sayfa Sayısı
[dc.identifier.endpage]
661
Dergi Adı
[dc.relation.journal]
Advances in Therapy
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
24
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/BF02848790
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5397
Görüntülenme Sayısı ( Şehir )
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Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
11
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
06 Şubat 2024 20:45
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Tıklayınız
Gln-enriched mucosal (group before injury scores groups intestinal respectively) significantly bacterial translocation support damage balanced without evaluation removed Mesenteric samples Intestinal histopathologic Communications Health ©2007 decreased result mesenteric Meanwhile investigation between parameters difference higher received
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