The effects of vitamin D on gentamicin-induced acute kidney injury in experimental rat model

Introduction. Acute kidney injury (AKI) pathogenesis is complex. Findings of gentamicin nephrotoxicity are seen in 30% of the AKI patients. Vitamin D has proven to be effective on renin expression, inflammatory response, oxidative stress, apoptosis, and atherosclerosis. We aimed to investigate the effect of vitamin D in an experimental rat model of gentamicin-induced AKI. Methods. Thirty nonuremic Wistar albino rats were divided into 3 groups: Control group, 1 mL saline intramuscular (im) daily; Genta group, gentamicin 100 mg/kg/day (im); Genta + vitamin D, gentamicin 100 mg/kg/day (im) in addition to 1?, 25 (OH)2D3 0.4 mcg/kg/day subcutaneously for 8 days. Blood pressures and 24-hour urine were measured. Blood urea and creatinine levels and urine tubular injury markers were measured. Renal histology was semiquantitatively assessed. Results. Urea, creatinine and urine neutrophil gelatinase-associated lipocalin, and kidney injury molecule-1 were all increased in Genta group indicating AKI model. Systolic blood pressure decreased, but urine volume and glutathione increased in Genta + Vit D group compared to Control group. Histological scores indicating tubular injury increased in Genta and Genta + Vit D groups. Conclusions. Vitamin D does not seem to be effective on histological findings although it has some beneficial effects via RAS system and a promising effect on antioxidant system. © 2013 Ender Hur et al.

Yazar Hur E.
Garip A.
Camyar A.
Ilgun S.
Ozisik M.
Tuna S.
Olukman M.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/8065
Tek Biçim Adres 10.1155/2013/313528
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
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Dergi Adı International Journal of Endocrinology
Dergi Cilt Bilgisi 2013
Sayfalar -
Yayın Yılı 2013
Eser Adı
[dc.title]
The effects of vitamin D on gentamicin-induced acute kidney injury in experimental rat model
Yazar
[dc.contributor.author]
Hur E.
Yazar
[dc.contributor.author]
Garip A.
Yazar
[dc.contributor.author]
Camyar A.
Yazar
[dc.contributor.author]
Ilgun S.
Yazar
[dc.contributor.author]
Ozisik M.
Yazar
[dc.contributor.author]
Tuna S.
Yazar
[dc.contributor.author]
Olukman M.
Yayın Yılı
[dc.date.issued]
2013
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Introduction. Acute kidney injury (AKI) pathogenesis is complex. Findings of gentamicin nephrotoxicity are seen in 30% of the AKI patients. Vitamin D has proven to be effective on renin expression, inflammatory response, oxidative stress, apoptosis, and atherosclerosis. We aimed to investigate the effect of vitamin D in an experimental rat model of gentamicin-induced AKI. Methods. Thirty nonuremic Wistar albino rats were divided into 3 groups: Control group, 1 mL saline intramuscular (im) daily; Genta group, gentamicin 100 mg/kg/day (im); Genta + vitamin D, gentamicin 100 mg/kg/day (im) in addition to 1?, 25 (OH)2D3 0.4 mcg/kg/day subcutaneously for 8 days. Blood pressures and 24-hour urine were measured. Blood urea and creatinine levels and urine tubular injury markers were measured. Renal histology was semiquantitatively assessed. Results. Urea, creatinine and urine neutrophil gelatinase-associated lipocalin, and kidney injury molecule-1 were all increased in Genta group indicating AKI model. Systolic blood pressure decreased, but urine volume and glutathione increased in Genta + Vit D group compared to Control group. Histological scores indicating tubular injury increased in Genta and Genta + Vit D groups. Conclusions. Vitamin D does not seem to be effective on histological findings although it has some beneficial effects via RAS system and a promising effect on antioxidant system. © 2013 Ender Hur et al.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1687-8337
Dergi Adı
[dc.relation.journal]
International Journal of Endocrinology
Dergi Cilt Bilgisi
[dc.identifier.volume]
2013
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1155/2013/313528
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/8065
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
5
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
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09 Şubat 2024 06:09
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injury increased gentamicin indicating mg/kg/day groups Control effect measured vitamin effective Vitamin kidney creatinine system tubular Results levels markers molecule-1 histology lipocalin gelatinase-associated neutrophil semiquantitatively assessed Systolic Introduction antioxidant promising effects beneficial pressure although findings
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