The protective effects of tadalafil on renal damage following ischemia reperfusion injury in rats

Ischemia-reperfusion injury can cause renal damage, and phosphodiesterase inhibitors are reported to regulate antioxidant activity. We investigated the prevention of renal damage using tadalafil after renal ischemia reperfusion (I/R) injury in rats. A total of 21 adult male Wistar albino rats were randomly divided into three groups of seven, including Group 1-control, Group 2-I/R, and Group 3-tadalafil + I/R group (I/R-T group) received tadalafil intraperitoneally at 30 minutes before ischemia. Inducible nitric oxide synthase, endothelial nitric oxide synthase, malondialdehyde, and total antioxidant capacity levels were evaluated, and histopathological changes and apoptosis in the groups were examined. Tadalafil decreased malondialdehyde levels in the I/R group and increased the total antioxidant capacity level. Histopathological and immunohistochemical findings revealed that tadalafil decreased renal injury scores and the ratios of injured cells, as measured through apoptotic protease activating factor 1, inducible nitric oxide synthase, and endothelial nitric oxide synthase levels. We suggest that tadalafil has protective effects against I/R-related renal tissue injury. © 2015, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved.

Yazar Erol B.
Turker T.
Tok A.
Bektas S.
Mungan G.
Ozkanli S.
Karakas B.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/8208
Tek Biçim Adres 10.1016/j.kjms.2015.06.005
Konu Başlıkları Ischemia reperfusion
Kidney
Tadalafil
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Kaohsiung Journal of Medical Sciences
Dergi Cilt Bilgisi 31
Dergi Sayısı 9
Sayfalar 454 - 462
Yayın Yılı 2015
Eser Adı
[dc.title]
The protective effects of tadalafil on renal damage following ischemia reperfusion injury in rats
Yazar
[dc.contributor.author]
Erol B.
Yazar
[dc.contributor.author]
Turker T.
Yazar
[dc.contributor.author]
Tok A.
Yazar
[dc.contributor.author]
Bektas S.
Yazar
[dc.contributor.author]
Mungan G.
Yazar
[dc.contributor.author]
Ozkanli S.
Yazar
[dc.contributor.author]
Karakas B.
Yayın Yılı
[dc.date.issued]
2015
Yayıncı
[dc.publisher]
Elsevier (Singapore) Pte Ltd
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Ischemia-reperfusion injury can cause renal damage, and phosphodiesterase inhibitors are reported to regulate antioxidant activity. We investigated the prevention of renal damage using tadalafil after renal ischemia reperfusion (I/R) injury in rats. A total of 21 adult male Wistar albino rats were randomly divided into three groups of seven, including Group 1-control, Group 2-I/R, and Group 3-tadalafil + I/R group (I/R-T group) received tadalafil intraperitoneally at 30 minutes before ischemia. Inducible nitric oxide synthase, endothelial nitric oxide synthase, malondialdehyde, and total antioxidant capacity levels were evaluated, and histopathological changes and apoptosis in the groups were examined. Tadalafil decreased malondialdehyde levels in the I/R group and increased the total antioxidant capacity level. Histopathological and immunohistochemical findings revealed that tadalafil decreased renal injury scores and the ratios of injured cells, as measured through apoptotic protease activating factor 1, inducible nitric oxide synthase, and endothelial nitric oxide synthase levels. We suggest that tadalafil has protective effects against I/R-related renal tissue injury. © 2015, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Ischemia reperfusion
Konu Başlıkları
[dc.subject]
Kidney
Konu Başlıkları
[dc.subject]
Tadalafil
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1607551X
İlk Sayfa Sayısı
[dc.identifier.startpage]
454
Son Sayfa Sayısı
[dc.identifier.endpage]
462
Dergi Adı
[dc.relation.journal]
Kaohsiung Journal of Medical Sciences
Dergi Sayısı
[dc.identifier.issue]
9
Dergi Cilt Bilgisi
[dc.identifier.volume]
31
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.kjms.2015.06.005
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/8208
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
21
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 07:05
Google Kontrol
Tıklayınız
injury tadalafil nitric synthase levels antioxidant ischemia groups damage decreased endothelial malondialdehyde capacity through measured increased injured ratios immunohistochemical scores revealed findings Histopathological Ischemia-reperfusion inducible apoptotic reserved rights Taiwan Elsevier Published University Medical Kaohsiung protease
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms