Anti-inflammatory efficiency of Ankaferd blood stopper in experimental distal colitis model

Background/Aim: Ankaferd blood stopper (ABS) is a herbal extract that enhances mucosal healing. In this study, we aimed to investigate the efficiency of ABS in the treatment of experimental distal colitis. Materials and Methods: Twenty one male albino rats were divided into three groups: Sham control (Group 1), colitis induced by acetic acid and treated with saline (Group 2), colitis induced by acetic acid and treated with ABS (Group 3). At end of the 7 th day of induction, all the rats were lightly anesthetized with intramuscular ketamine (8 mg/kg) and thereafter laparotomy and total colectomy were performed. The distal colon segment was assessed macroscopically and microscopically. In addition malondialdehyde (MDA), superoxide dismutase (SOD) and nitric oxide (NO) levels of the colonic tissue and changes in body weight were measured. Results: The MDA and NO levels of the colonic tissues and weight loss were significantly higher in Group 2 compared to Group 1 and Group 3. Microscopic and macroscopic damage scores were significantly higher in Group 2 and Group 3 than Group 1 (P: 0.001, P: 0.004, respectively). Although the microscopic and macroscopic damage scores in Group 3 were slightly lower than Group 2, the difference was not statistically significant. The SOD levels of the colonic tissues were not different between the three groups. Conclusion: Weight alterations and high-levels of the colonic tissue MDA and NO suggested that ABS might have anti-inflammatory effects on experimental distal colitis. However, this suggestion was not supported by histopathological findings.

Yazar Koçak E.
Akbal E.
Tas A.
Köklü S.
Karaca G.
Can M.
Kösem B.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/4308
Tek Biçim Adres 10.4103/1319-3767.111955
Konu Başlıkları Acetic acid
ankaferd blood stopper
experimental colitis
malondialdehyde
nitric oxide
superoxide dismutase
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Saudi Journal of Gastroenterology
Dergi Cilt Bilgisi 19
Dergi Sayısı 3
Sayfalar 126 - 130
Yayın Yılı 2013
Eser Adı
[dc.title]
Anti-inflammatory efficiency of Ankaferd blood stopper in experimental distal colitis model
Yazar
[dc.contributor.author]
Koçak E.
Yazar
[dc.contributor.author]
Akbal E.
Yazar
[dc.contributor.author]
Tas A.
Yazar
[dc.contributor.author]
Köklü S.
Yazar
[dc.contributor.author]
Karaca G.
Yazar
[dc.contributor.author]
Can M.
Yazar
[dc.contributor.author]
Kösem B.
Yayın Yılı
[dc.date.issued]
2013
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background/Aim: Ankaferd blood stopper (ABS) is a herbal extract that enhances mucosal healing. In this study, we aimed to investigate the efficiency of ABS in the treatment of experimental distal colitis. Materials and Methods: Twenty one male albino rats were divided into three groups: Sham control (Group 1), colitis induced by acetic acid and treated with saline (Group 2), colitis induced by acetic acid and treated with ABS (Group 3). At end of the 7 th day of induction, all the rats were lightly anesthetized with intramuscular ketamine (8 mg/kg) and thereafter laparotomy and total colectomy were performed. The distal colon segment was assessed macroscopically and microscopically. In addition malondialdehyde (MDA), superoxide dismutase (SOD) and nitric oxide (NO) levels of the colonic tissue and changes in body weight were measured. Results: The MDA and NO levels of the colonic tissues and weight loss were significantly higher in Group 2 compared to Group 1 and Group 3. Microscopic and macroscopic damage scores were significantly higher in Group 2 and Group 3 than Group 1 (P: 0.001, P: 0.004, respectively). Although the microscopic and macroscopic damage scores in Group 3 were slightly lower than Group 2, the difference was not statistically significant. The SOD levels of the colonic tissues were not different between the three groups. Conclusion: Weight alterations and high-levels of the colonic tissue MDA and NO suggested that ABS might have anti-inflammatory effects on experimental distal colitis. However, this suggestion was not supported by histopathological findings.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Acetic acid
Konu Başlıkları
[dc.subject]
ankaferd blood stopper
Konu Başlıkları
[dc.subject]
experimental colitis
Konu Başlıkları
[dc.subject]
malondialdehyde
Konu Başlıkları
[dc.subject]
nitric oxide
Konu Başlıkları
[dc.subject]
superoxide dismutase
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1319-3767
İlk Sayfa Sayısı
[dc.identifier.startpage]
126
Son Sayfa Sayısı
[dc.identifier.endpage]
130
Dergi Adı
[dc.relation.journal]
Saudi Journal of Gastroenterology
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
19
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.4103/1319-3767.111955
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4308
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
7
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 08:04
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Tıklayınız
colitis colonic (Group distal levels induced scores groups macroscopic higher experimental significantly tissues acetic weight treated tissue damage Background/Aim Microscopic compared Results measured changes Although alterations findings histopathological supported suggestion However effects anti-inflammatory suggested high-levels
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