Effect of nitric oxide synthase inhibitors in acute lung injury due to blunt lung trauma in rats

Background: This study aims to investigate the effects of blunt lung trauma performed in experimental rat model on lung tissue and blood as well as proinflammatory cytokines, oxidant-antioxidant enzymes and histopathological parameters after Ngamma-nitro-L-arginine methyl ester and N-iminoethyl-L-ornithine administration. Methods: The study included 50 adult male Wistar albino rats (weighing 350 to 400 g). Rats were randomly allocated into four groups. Except in the control, moderate-level pulmonary contusion was created in all other groups. Intraperitoneal saline solution was performed in groups 1 and 2, 25 mg.kg(-1) Ngamma-nitro-L-arginine methyl ester in group 3, and 20 mg. kg(-1) N-iminoethyl-L-ornithine in group 4. Blood and lung tissues were studied biochemically and histopathologically. Results: Best outcomes were recorded statistically significantly in groups with administration of Ngamma-nitro-L-arginine methyl ester and N-iminoethyl-L-ornithine when malondialdehyde response, mucous and histopathological values were examined. Significant improvement was detected in superoxide dismutase values in the group with administration of competitive nitric oxide synthase inhibitor Ngamma-nitro-L-arginine methyl ester. Nitric oxide values were substantially decreased in N-iminoethyl-L-ornithine group, while no significance was detected. Conclusion: Free oxygen radicals and lipid peroxidation played a role in pulmonary contusion after blunt lung trauma. According to biochemical and histopathological outcomes, effects of inflammation were decreased and protective effects were formed with administration of both Ngammanitro-L-arginine methyl ester and N-iminoethyl-L-ornithine.

Yazar Akgul, Ash Gul
Sahin, Deniz
Temel, Ugur
Elicora, Aykut
Dillioglugil, Meltem
Kir, Hale Maral
Ozsoy, Ozgur Doga
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2458
Tek Biçim Adres 10.5606/tgkdc.dergisi.2019.15936
Konu Başlıkları Acute lung injury
oxidative stress
trauma
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
Dergi Cilt Bilgisi 27
Dergi Sayısı 1
Sayfalar 63 - 72
Yayın Yılı 2019
Eser Adı
[dc.title]
Effect of nitric oxide synthase inhibitors in acute lung injury due to blunt lung trauma in rats
Yazar
[dc.contributor.author]
Akgul, Ash Gul
Yazar
[dc.contributor.author]
Sahin, Deniz
Yazar
[dc.contributor.author]
Temel, Ugur
Yazar
[dc.contributor.author]
Elicora, Aykut
Yazar
[dc.contributor.author]
Dillioglugil, Meltem
Yazar
[dc.contributor.author]
Kir, Hale Maral
Yazar
[dc.contributor.author]
Ozsoy, Ozgur Doga
Yayın Yılı
[dc.date.issued]
2019
Yayıncı
[dc.publisher]
BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: This study aims to investigate the effects of blunt lung trauma performed in experimental rat model on lung tissue and blood as well as proinflammatory cytokines, oxidant-antioxidant enzymes and histopathological parameters after Ngamma-nitro-L-arginine methyl ester and N-iminoethyl-L-ornithine administration. Methods: The study included 50 adult male Wistar albino rats (weighing 350 to 400 g). Rats were randomly allocated into four groups. Except in the control, moderate-level pulmonary contusion was created in all other groups. Intraperitoneal saline solution was performed in groups 1 and 2, 25 mg.kg(-1) Ngamma-nitro-L-arginine methyl ester in group 3, and 20 mg. kg(-1) N-iminoethyl-L-ornithine in group 4. Blood and lung tissues were studied biochemically and histopathologically. Results: Best outcomes were recorded statistically significantly in groups with administration of Ngamma-nitro-L-arginine methyl ester and N-iminoethyl-L-ornithine when malondialdehyde response, mucous and histopathological values were examined. Significant improvement was detected in superoxide dismutase values in the group with administration of competitive nitric oxide synthase inhibitor Ngamma-nitro-L-arginine methyl ester. Nitric oxide values were substantially decreased in N-iminoethyl-L-ornithine group, while no significance was detected. Conclusion: Free oxygen radicals and lipid peroxidation played a role in pulmonary contusion after blunt lung trauma. According to biochemical and histopathological outcomes, effects of inflammation were decreased and protective effects were formed with administration of both Ngammanitro-L-arginine methyl ester and N-iminoethyl-L-ornithine.
Açıklama
[dc.description]
WOS: 000455260600010
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Acute lung injury
Konu Başlıkları
[dc.subject]
oxidative stress
Konu Başlıkları
[dc.subject]
trauma
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1301-5680
İlk Sayfa Sayısı
[dc.identifier.startpage]
63
Son Sayfa Sayısı
[dc.identifier.endpage]
72
Dergi Adı
[dc.relation.journal]
TURK GOGUS KALP DAMAR CERRAHISI DERGISI-TURKISH JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
27
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.5606/tgkdc.dergisi.2019.15936
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2458
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
16
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
06 Şubat 2024 17:41
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Tıklayınız
methyl N-iminoethyl-L-ornithine administration groups Ngamma-nitro-L-arginine histopathological effects values contusion decreased pulmonary detected trauma outcomes kg(-1) performed improvement histopathologically Significant examined Results mucous response malondialdehyde recorded statistically significantly Background superoxide Ngammanitro-L-arginine formed protective inflammation biochemical According
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