Insulin resistance and serum leptin levels in men with obstructive sleep apnea syndrome [Obstrüktif uyku apne sendromu olan erkek hastalarda i·nsülin rezistansi ve serum leptin seviyeleri]

Aim: The aim of this study was to assess the insulin resistance and serum leptin levels in patients with obstructive sleep apnea syndrome (OSAS), and to compare body mass indexes (BMI) of OSAS patients with matched controls without OSAS. Method: Twenty eight patients having apnea-hypopnea index (AHI)?5 included in the study. Thirty two healthy subjects assumed as a control group. Venous blood was obtained in the fasting state for the measurement of glucose, insulin and leptin levels. Insulin resistance index was based on the homeostasis model assesment method (HOMA-IR). Result: There was no significant difference in the serum leptin levels (control group, 32.88±24.22 ng/ml, OSAS group, 24.93±25.84 ng/ml) and HOMA-IR (control group, 3.01±1.81, OSAS group, 2.58±1.21) between control group and OSAS patients. Insulin resistance and circulating plasma leptin concentrations in OSAS patients were independent of the AHI and were not different from the control group. Conclusion: We concluded that insulin resistance and plasma leptin concentrations are mostly associated with the degree of obesity and BMI. Those parameters seem not to be related with the AHI in OSAS patients.

Yazar Koçak E.
Koçak G.
Örnek T.
Bakirtaş H.
Atmaca H.
Can M.
Bayraktaroglu T.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/6271
Konu Başlıkları Apnea hypopnea index
Insulin resistance
Leptin
OSAS
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı European Journal of General Medicine
Dergi Cilt Bilgisi 8
Dergi Sayısı 4
Sayfalar 273 - 279
Yayın Yılı 2011
Eser Adı
[dc.title]
Insulin resistance and serum leptin levels in men with obstructive sleep apnea syndrome [Obstrüktif uyku apne sendromu olan erkek hastalarda i·nsülin rezistansi ve serum leptin seviyeleri]
Yazar
[dc.contributor.author]
Koçak E.
Yazar
[dc.contributor.author]
Koçak G.
Yazar
[dc.contributor.author]
Örnek T.
Yazar
[dc.contributor.author]
Bakirtaş H.
Yazar
[dc.contributor.author]
Atmaca H.
Yazar
[dc.contributor.author]
Can M.
Yazar
[dc.contributor.author]
Bayraktaroglu T.
Yayın Yılı
[dc.date.issued]
2011
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Aim: The aim of this study was to assess the insulin resistance and serum leptin levels in patients with obstructive sleep apnea syndrome (OSAS), and to compare body mass indexes (BMI) of OSAS patients with matched controls without OSAS. Method: Twenty eight patients having apnea-hypopnea index (AHI)?5 included in the study. Thirty two healthy subjects assumed as a control group. Venous blood was obtained in the fasting state for the measurement of glucose, insulin and leptin levels. Insulin resistance index was based on the homeostasis model assesment method (HOMA-IR). Result: There was no significant difference in the serum leptin levels (control group, 32.88±24.22 ng/ml, OSAS group, 24.93±25.84 ng/ml) and HOMA-IR (control group, 3.01±1.81, OSAS group, 2.58±1.21) between control group and OSAS patients. Insulin resistance and circulating plasma leptin concentrations in OSAS patients were independent of the AHI and were not different from the control group. Conclusion: We concluded that insulin resistance and plasma leptin concentrations are mostly associated with the degree of obesity and BMI. Those parameters seem not to be related with the AHI in OSAS patients.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Apnea hypopnea index
Konu Başlıkları
[dc.subject]
Insulin resistance
Konu Başlıkları
[dc.subject]
Leptin
Konu Başlıkları
[dc.subject]
OSAS
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1304-3889
İlk Sayfa Sayısı
[dc.identifier.startpage]
273
Son Sayfa Sayısı
[dc.identifier.endpage]
279
Dergi Adı
[dc.relation.journal]
European Journal of General Medicine
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
8
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/6271
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
14
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
17 Nisan 2024 18:00
Google Kontrol
Tıklayınız
patients leptin resistance insulin levels control Insulin concentrations (control plasma HOMA-IR ng/ml) 93±25 88±24 difference significant different associated related parameters obesity degree mostly between concluded Conclusion independent circulating measurement Result Twenty Method without controls matched
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms