A retrospective evaluation of the epithelial changes/lesions and neoplasms of the Gallbladder in Turkey and a review of the existing sampling methods: A multicentre study

Objective: As there is continuing disagreement among the observers on the differential diagnosis between the epithelial changes/lesions and neoplasms of the gallbladder, this multicentre study was planned in order to assess the rate of the epithelial gallbladder lesions in Turkey and to propose microscopy and macroscopy protocols. Material and Method: With the participation of 22 institutions around Turkey that were included in the Hepato-Pancreato-Biliary Study Group, 89,324 cholecystectomy specimens sampled from 2003 to 2016 were retrospectively evaluated. The numbers of adenocarcinomas, dysplasias, intracholecystic neoplasms/adenomas, intestinal metaplasias and reactive atypia were identified with the review of pathology reports and the regional and countrywide incidence rates were presented in percentages. Results: Epithelial changes/lesions were reported in 6% of cholecystectomy materials. Of these epithelial lesions, 7% were reported as adenocarcinoma, 0.9% as high-grade dysplasia, 4% as low-grade dysplasia, 7.8% as reactive/regenerative atypia, 1.7% as neoplastic polyp, and 15.6% as intestinal metaplasia. The remaining lesions (63%) primarily included non-neoplastic polypoids/hyperplastic lesions and antral/pyloric metaplasia. There were also differences between pathology laboratories. Conclusion: The major causes of the difference in reporting these epithelial changes/lesions and neoplasms include the differences related to the institute’s oncological surgery frequency, sampling protocols, geographical dissimilarities, and differences in the diagnoses/interpretations of the pathologists. It seems that the diagnosis may change if new sections are taken from the specimen when any epithelial abnormality is seen during microscopic examination of the cholecystectomy materials. © 2018, Federation of Turkish Pathology Societies. All rights reserved.

Yazar Esendağli G.
Akarca F.G.
Balci S.
Argon A.
Şengiz Erhan S.
Turhan N.
İnce Zengin N.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/4045
Tek Biçim Adres 10.5146/tjpath.2017.01404
Konu Başlıkları Cholecystectomy
Dysplasia
Gallbladder
Neoplasia
Sampling
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Turk Patoloji Dergisi
Dergi Cilt Bilgisi 34
Dergi Sayısı 1
Sayfalar 41 - 48
Yayın Yılı 2018
Eser Adı
[dc.title]
A retrospective evaluation of the epithelial changes/lesions and neoplasms of the Gallbladder in Turkey and a review of the existing sampling methods: A multicentre study
Yazar
[dc.contributor.author]
Esendağli G.
Yazar
[dc.contributor.author]
Akarca F.G.
Yazar
[dc.contributor.author]
Balci S.
Yazar
[dc.contributor.author]
Argon A.
Yazar
[dc.contributor.author]
Şengiz Erhan S.
Yazar
[dc.contributor.author]
Turhan N.
Yazar
[dc.contributor.author]
İnce Zengin N.
Yayın Yılı
[dc.date.issued]
2018
Yayıncı
[dc.publisher]
Federation of Turkish Pathology Societies
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: As there is continuing disagreement among the observers on the differential diagnosis between the epithelial changes/lesions and neoplasms of the gallbladder, this multicentre study was planned in order to assess the rate of the epithelial gallbladder lesions in Turkey and to propose microscopy and macroscopy protocols. Material and Method: With the participation of 22 institutions around Turkey that were included in the Hepato-Pancreato-Biliary Study Group, 89,324 cholecystectomy specimens sampled from 2003 to 2016 were retrospectively evaluated. The numbers of adenocarcinomas, dysplasias, intracholecystic neoplasms/adenomas, intestinal metaplasias and reactive atypia were identified with the review of pathology reports and the regional and countrywide incidence rates were presented in percentages. Results: Epithelial changes/lesions were reported in 6% of cholecystectomy materials. Of these epithelial lesions, 7% were reported as adenocarcinoma, 0.9% as high-grade dysplasia, 4% as low-grade dysplasia, 7.8% as reactive/regenerative atypia, 1.7% as neoplastic polyp, and 15.6% as intestinal metaplasia. The remaining lesions (63%) primarily included non-neoplastic polypoids/hyperplastic lesions and antral/pyloric metaplasia. There were also differences between pathology laboratories. Conclusion: The major causes of the difference in reporting these epithelial changes/lesions and neoplasms include the differences related to the institute’s oncological surgery frequency, sampling protocols, geographical dissimilarities, and differences in the diagnoses/interpretations of the pathologists. It seems that the diagnosis may change if new sections are taken from the specimen when any epithelial abnormality is seen during microscopic examination of the cholecystectomy materials. © 2018, Federation of Turkish Pathology Societies. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Cholecystectomy
Konu Başlıkları
[dc.subject]
Dysplasia
Konu Başlıkları
[dc.subject]
Gallbladder
Konu Başlıkları
[dc.subject]
Neoplasia
Konu Başlıkları
[dc.subject]
Sampling
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1018-5615
İlk Sayfa Sayısı
[dc.identifier.startpage]
41
Son Sayfa Sayısı
[dc.identifier.endpage]
48
Dergi Adı
[dc.relation.journal]
Turk Patoloji Dergisi
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
34
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.5146/tjpath.2017.01404
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4045
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
22
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
18 Ocak 2024 13:59
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Tıklayınız
epithelial lesions cholecystectomy differences changes/lesions between metaplasia intestinal included atypia pathology diagnosis Turkey protocols reported neoplasms gallbladder materials dysplasia remaining neoplastic reporting difference causes Conclusion include laboratories primarily non-neoplastic reactive/regenerative antral/pyloric polypoids/hyperplastic Objective related abnormality
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