The effects of dexmedetomidine dosage on cerebral vasospasm in a rat subarachnoid haemorrhage model

We investigated the effect of two different doses of dexmedetomidine on vasospasm in a rat model of subarachnoid haemorrhage (SAH). SAH was induced by injecting 0.3 mL blood into the cisterna magna in all rat groups except the control (Group C). At 1 hour and 24 hours after SAH, 5 µg/kg dexmedetomidine was given to group D5, and 10 µg/kg dexmedetomidine was given to group D10. No medication was administered to the haemorrhage group (Group H). Malondialdehyde (MDA) and paraoxonase (PON) levels were measured at 48 hours after SAH. Mean wall thickness (MWT), mean luminal diameter (MLD), and proliferating cell nuclear antigen (PCNA) expression of the basilar artery were evaluated. MDA levels and MWT were lower in the dexmedetomidine groups. The lowest MDA levels and MWT were found in Group D10. The MLD was lowest in Group H. PCNA expression was observed only in Group D10. We concluded that dexmedetomidine reduces oxidative stress and vasospasm following SAH in a dose-dependent manner. © 2009 Elsevier Ltd. All rights reserved.

Yazar Ayoglu H.
Gul S.
Hanci V.
Bahadir B.
Bektas S.
Mungan A.G.
Turan I.O.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/8019
Tek Biçim Adres 10.1016/j.jocn.2009.10.012
Konu Başlıkları Cerebral vasospasm
Dexmedetomidine
Subarachnoid haemorrhage
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Journal of Clinical Neuroscience
Dergi Cilt Bilgisi 17
Dergi Sayısı 6
Sayfalar 770 - 773
Yayın Yılı 2010
Eser Adı
[dc.title]
The effects of dexmedetomidine dosage on cerebral vasospasm in a rat subarachnoid haemorrhage model
Yazar
[dc.contributor.author]
Ayoglu H.
Yazar
[dc.contributor.author]
Gul S.
Yazar
[dc.contributor.author]
Hanci V.
Yazar
[dc.contributor.author]
Bahadir B.
Yazar
[dc.contributor.author]
Bektas S.
Yazar
[dc.contributor.author]
Mungan A.G.
Yazar
[dc.contributor.author]
Turan I.O.
Yayın Yılı
[dc.date.issued]
2010
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
We investigated the effect of two different doses of dexmedetomidine on vasospasm in a rat model of subarachnoid haemorrhage (SAH). SAH was induced by injecting 0.3 mL blood into the cisterna magna in all rat groups except the control (Group C). At 1 hour and 24 hours after SAH, 5 µg/kg dexmedetomidine was given to group D5, and 10 µg/kg dexmedetomidine was given to group D10. No medication was administered to the haemorrhage group (Group H). Malondialdehyde (MDA) and paraoxonase (PON) levels were measured at 48 hours after SAH. Mean wall thickness (MWT), mean luminal diameter (MLD), and proliferating cell nuclear antigen (PCNA) expression of the basilar artery were evaluated. MDA levels and MWT were lower in the dexmedetomidine groups. The lowest MDA levels and MWT were found in Group D10. The MLD was lowest in Group H. PCNA expression was observed only in Group D10. We concluded that dexmedetomidine reduces oxidative stress and vasospasm following SAH in a dose-dependent manner. © 2009 Elsevier Ltd. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Cerebral vasospasm
Konu Başlıkları
[dc.subject]
Dexmedetomidine
Konu Başlıkları
[dc.subject]
Subarachnoid haemorrhage
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0967-5868
İlk Sayfa Sayısı
[dc.identifier.startpage]
770
Son Sayfa Sayısı
[dc.identifier.endpage]
773
Dergi Adı
[dc.relation.journal]
Journal of Clinical Neuroscience
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
17
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.jocn.2009.10.012
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/8019
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
37
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 22:10
Google Kontrol
Tıklayınız
dexmedetomidine levels (Group µg/kg groups lowest expression vasospasm haemorrhage luminal diameter proliferating basilar antigen evaluated artery (PCNA) nuclear following reserved rights Elsevier manner dose-dependent stress oxidative reduces concluded observed thickness cisterna injecting induced except subarachnoid
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms