The prevalence of mixed genotype infections in Turkish patients with hepatitis C: A multicentered assessment

Background: HCV virus infections are one of the major health problems in the world that can cause cirrhosis and liver cancer at a higher rate than other hepatitis data. The aim of this study was to determine the prevalence of mixed infections with different HCV genotypes in Turkey and also to evaluate the current HCV genotype and subtype distributions by a multicentered assessment. Methods: The HCV genotype data of 17,578 hepatitis C patients collected from 23 centers from different geographic regions covering all Turkey were collected. The data included information about the HCV genotypes in the last 10 years (between 2007 and 2016), demographic properties of the patients and the methods/systems used to determine the genotypes. Results: Two hundred twenty-eight of the patients (1.3%) had mixed genotype. The most common mixed genotype combination was 1b + 4 (0.83%) followed by 1a + 1b (0.26%). Genotype distribution varies according to geographical regions. However, genotype 1 (82.92%) was the most common genotype in all regions and all years. This was followed by genotype 3 (7.07%) and genotype 4 (5.43%). A variety of methods were used by the centers including sequencing, pyrosequencing, real-time PCR, in-house RFLP, reverse hybridization (LIPA), and hybridization. Conclusions: Infection with mixed HCV genotypes in Turkey is uncommon. Genotype distribution varies according to geographic regions; the most common genotype 1 is encountered all over the country, while genotypes 3 and 4 are only in some of the centers. Since there is limited information about mixed HCV infection, further investigations are needed to determine the clinical importance of mixed HCV infection. © 2019 Verlag Klinisches Labor GmbH. All rights reserved.

Yazar Kulah C.
Altindis M.
Akyar I.
Gokahmetoglu S.
Sayiner A.
Kaleli I.
Fidan I.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/8198
Tek Biçim Adres 10.7754/Clin.Lab.2018.180824
Konu Başlıkları Genotypes
HCV
Mixed genotypes
Multicenter
Turkey
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Clinical Laboratory
Dergi Cilt Bilgisi 65
Dergi Sayısı 4
Sayfalar 485 - 490
Yayın Yılı 2019
Eser Adı
[dc.title]
The prevalence of mixed genotype infections in Turkish patients with hepatitis C: A multicentered assessment
Yazar
[dc.contributor.author]
Kulah C.
Yazar
[dc.contributor.author]
Altindis M.
Yazar
[dc.contributor.author]
Akyar I.
Yazar
[dc.contributor.author]
Gokahmetoglu S.
Yazar
[dc.contributor.author]
Sayiner A.
Yazar
[dc.contributor.author]
Kaleli I.
Yazar
[dc.contributor.author]
Fidan I.
Yayın Yılı
[dc.date.issued]
2019
Yayıncı
[dc.publisher]
Verlag Klinisches Labor GmbH
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: HCV virus infections are one of the major health problems in the world that can cause cirrhosis and liver cancer at a higher rate than other hepatitis data. The aim of this study was to determine the prevalence of mixed infections with different HCV genotypes in Turkey and also to evaluate the current HCV genotype and subtype distributions by a multicentered assessment. Methods: The HCV genotype data of 17,578 hepatitis C patients collected from 23 centers from different geographic regions covering all Turkey were collected. The data included information about the HCV genotypes in the last 10 years (between 2007 and 2016), demographic properties of the patients and the methods/systems used to determine the genotypes. Results: Two hundred twenty-eight of the patients (1.3%) had mixed genotype. The most common mixed genotype combination was 1b + 4 (0.83%) followed by 1a + 1b (0.26%). Genotype distribution varies according to geographical regions. However, genotype 1 (82.92%) was the most common genotype in all regions and all years. This was followed by genotype 3 (7.07%) and genotype 4 (5.43%). A variety of methods were used by the centers including sequencing, pyrosequencing, real-time PCR, in-house RFLP, reverse hybridization (LIPA), and hybridization. Conclusions: Infection with mixed HCV genotypes in Turkey is uncommon. Genotype distribution varies according to geographic regions; the most common genotype 1 is encountered all over the country, while genotypes 3 and 4 are only in some of the centers. Since there is limited information about mixed HCV infection, further investigations are needed to determine the clinical importance of mixed HCV infection. © 2019 Verlag Klinisches Labor GmbH. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Genotypes
Konu Başlıkları
[dc.subject]
HCV
Konu Başlıkları
[dc.subject]
Mixed genotypes
Konu Başlıkları
[dc.subject]
Multicenter
Konu Başlıkları
[dc.subject]
Turkey
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1433-6510
İlk Sayfa Sayısı
[dc.identifier.startpage]
485
Son Sayfa Sayısı
[dc.identifier.endpage]
490
Dergi Adı
[dc.relation.journal]
Clinical Laboratory
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
65
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.7754/Clin.Lab.2018.180824
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/8198
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
13
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
29 Ocak 2024 21:03
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Tıklayınız
genotype genotypes regions Turkey common determine patients centers different distribution varies collected geographic hybridization information infection followed according hepatitis infections Genotype geographical pyrosequencing However methods sequencing including variety Background real-time further reserved rights Klinisches Verlag
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