Bacterial translocation in experimental stroke: What happens to the gut barrier?

The reasons of post-stroke infections are still incompletely understood. Bacterial translocation (BT), the passage of viable microbes across an even anatomically intact intestinal barrier, has been described in many critical illnesses. To date, it has not been studied as a source of infection in an animal stroke model. To address this, a permanent left middle cerebral artery occlusion (MCAO) model in rats was used. After 24, 48, and 72 hours (h), sham and experimental groups were sacrificed and samples were taken for BT. Similarity between bacteria detected in tissues (blood, mesenteric lymph node, liver, spleen, and lung) and intestinal microflora was shown with phenotypic methods and antibiotyping. Possible ileum tissue injuries were shown by histopathologic examination (including morphometric analysis). Although there was no bacterial proliferation in the sham groups, 55.5 %, 45.4 %, and 30 % bacterial proliferation was detected in MCAO groups at postoperative hour 24, 48, and 72, respectively. In MCAO groups the bacterial proliferation in tissues and ileum tissue injury scores were higher over time compared to sham groups (p<0.05). Our findings support the view that stroke, itself leads to mucosal damage and bacterial translocation.

Dergi Adı Bratislava Medical Journal
Dergi Cilt Bilgisi 111
Dergi Sayısı 4
Sayfalar 194 - 199
Yayın Yılı 2010
Eser Adı
[dc.title]
Bacterial translocation in experimental stroke: What happens to the gut barrier?
Yazar
[dc.contributor.author]
Tascilar N.
Yazar
[dc.contributor.author]
Irkorucu O.
Yazar
[dc.contributor.author]
Tascilar O.
Yazar
[dc.contributor.author]
Comert F.
Yazar
[dc.contributor.author]
Eroglu O.
Yazar
[dc.contributor.author]
Bahadir B.
Yazar
[dc.contributor.author]
Cakmak G.K.
Yayın Yılı
[dc.date.issued]
2010
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
The reasons of post-stroke infections are still incompletely understood. Bacterial translocation (BT), the passage of viable microbes across an even anatomically intact intestinal barrier, has been described in many critical illnesses. To date, it has not been studied as a source of infection in an animal stroke model. To address this, a permanent left middle cerebral artery occlusion (MCAO) model in rats was used. After 24, 48, and 72 hours (h), sham and experimental groups were sacrificed and samples were taken for BT. Similarity between bacteria detected in tissues (blood, mesenteric lymph node, liver, spleen, and lung) and intestinal microflora was shown with phenotypic methods and antibiotyping. Possible ileum tissue injuries were shown by histopathologic examination (including morphometric analysis). Although there was no bacterial proliferation in the sham groups, 55.5 %, 45.4 %, and 30 % bacterial proliferation was detected in MCAO groups at postoperative hour 24, 48, and 72, respectively. In MCAO groups the bacterial proliferation in tissues and ileum tissue injury scores were higher over time compared to sham groups (p<0.05). Our findings support the view that stroke, itself leads to mucosal damage and bacterial translocation.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Bacterial translocation
Konu Başlıkları
[dc.subject]
Gut barrier
Konu Başlıkları
[dc.subject]
ICAM-1
Konu Başlıkları
[dc.subject]
Infection
Konu Başlıkları
[dc.subject]
Inflammation
Konu Başlıkları
[dc.subject]
Stroke
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0006-9248
İlk Sayfa Sayısı
[dc.identifier.startpage]
194
Son Sayfa Sayısı
[dc.identifier.endpage]
199
Dergi Adı
[dc.relation.journal]
Bratislava Medical Journal
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
111
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4468
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
35
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 08:17
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Tıklayınız
groups bacterial proliferation translocation stroke tissues detected tissue intestinal (including phenotypic analysis) morphometric antibiotyping Possible injuries methods microflora examination Although histopathologic damage mucosal itself support findings compared higher scores injury respectively postoperative spleen samples studied
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