Effects of dexmedetomidine pretreatment on bupivacaine cardiotoxicity in rats

Background and Objective: We evaluated the effects of dexmedetomidine pretreatment on bupivacaine cardiotoxicity in anesthetized rats. Methods: Sixteen Wistar-Albino male rats (300-400 g) were anesthetized with ketamine. Electrocardiographic and invasive blood pressure monitoring were performed, and the results were continuously recorded. The rats were randomized into 2 groups. In group D, rats were pretreated with intravenous dexmedetomidine at a dose of 10 µg/kg (n = 8), whereas in group S, rats were pretreated with intravenous saline (n = 8). Fifteen minutes later, bupivacaine was infused at a rate of 3 mg/kg per minute until cardiac asystole occurred. The timing of specific cardiotoxic events (a 25%, 50%, and 75% reductions of mean arterial pressure and heart rate as well as occurrence of the first arrhythmia and asystole) was recorded. Results: Dexmedetomidine pretreatment reduced the heart rates and mean arterial pressures of the rats who received it (P < 0.05). Dexmedetomidine pretreatment before bupivacaine administration also significantly increased the time to the 25%, 50%, and 75% reductions in mean arterial pressure and the time to the 25% and 50% reductions in heart rate (P < 0.05). In addition, dexmedetomidine significantly increased the time to first arrhythmia and time to asystole (P < 0.05) in the rats who received it before receiving bupivacaine. Conclusions: Dexmedetomidine pretreatment delays the effects of bupivacaine cardiotoxicity. Copyright © 2009 by American Society of Regional Anesthesia and Pain Medicine.

Yazar Hanci V.
Karakaya K.
Yurtlu S.
Hakimoglu S.
Can M.
Ayoglu H.
Erdogan G.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/5456
Tek Biçim Adres 10.1097/AAP.0b013e3181bfbe35
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Regional Anesthesia and Pain Medicine
Dergi Cilt Bilgisi 34
Dergi Sayısı 6
Sayfalar 565 - 568
Yayın Yılı 2009
Eser Adı
[dc.title]
Effects of dexmedetomidine pretreatment on bupivacaine cardiotoxicity in rats
Yazar
[dc.contributor.author]
Hanci V.
Yazar
[dc.contributor.author]
Karakaya K.
Yazar
[dc.contributor.author]
Yurtlu S.
Yazar
[dc.contributor.author]
Hakimoglu S.
Yazar
[dc.contributor.author]
Can M.
Yazar
[dc.contributor.author]
Ayoglu H.
Yazar
[dc.contributor.author]
Erdogan G.
Yayın Yılı
[dc.date.issued]
2009
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background and Objective: We evaluated the effects of dexmedetomidine pretreatment on bupivacaine cardiotoxicity in anesthetized rats. Methods: Sixteen Wistar-Albino male rats (300-400 g) were anesthetized with ketamine. Electrocardiographic and invasive blood pressure monitoring were performed, and the results were continuously recorded. The rats were randomized into 2 groups. In group D, rats were pretreated with intravenous dexmedetomidine at a dose of 10 µg/kg (n = 8), whereas in group S, rats were pretreated with intravenous saline (n = 8). Fifteen minutes later, bupivacaine was infused at a rate of 3 mg/kg per minute until cardiac asystole occurred. The timing of specific cardiotoxic events (a 25%, 50%, and 75% reductions of mean arterial pressure and heart rate as well as occurrence of the first arrhythmia and asystole) was recorded. Results: Dexmedetomidine pretreatment reduced the heart rates and mean arterial pressures of the rats who received it (P < 0.05). Dexmedetomidine pretreatment before bupivacaine administration also significantly increased the time to the 25%, 50%, and 75% reductions in mean arterial pressure and the time to the 25% and 50% reductions in heart rate (P < 0.05). In addition, dexmedetomidine significantly increased the time to first arrhythmia and time to asystole (P < 0.05) in the rats who received it before receiving bupivacaine. Conclusions: Dexmedetomidine pretreatment delays the effects of bupivacaine cardiotoxicity. Copyright © 2009 by American Society of Regional Anesthesia and Pain Medicine.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1098-7339
İlk Sayfa Sayısı
[dc.identifier.startpage]
565
Son Sayfa Sayısı
[dc.identifier.endpage]
568
Dergi Adı
[dc.relation.journal]
Regional Anesthesia and Pain Medicine
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
34
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1097/AAP.0b013e3181bfbe35
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5456
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
201
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
17 Temmuz 2024 02:32
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bupivacaine pretreatment Dexmedetomidine arterial reductions pressure dexmedetomidine received anesthetized cardiotoxicity intravenous arrhythmia asystole effects pretreated before increased recorded significantly delays Conclusions Medicine Anesthesia receiving addition Copyright occurrence asystole) Results Society Regional reduced pressures American administration
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