New Method to Predict Survival in Hemodialysis Patients Using the Impedance Ratio

Objective: Bioimpedance spectroscopy (BIS) can be used to determine hypervolemia and malnutrition in chronic hemodialysis (HD) patients. In this prospective observational study, we investigated the survival predictability of impedance ratio (IR) calculated by BIS in HD patients (Clinical Trials Gov Identifier: NCT01468363). Materials and Methods: A total of 430 chronic HD patients, out of 500 prevalent chronic HD patients from the city of Zonguldak who met the inclusion criteria, were included in the study. With a mean follow-up of 32.2 +/- 14.4 months, BIS was performed in all patients. The IR percentage (IR%) was calculated by dividing the resistance values using the 200 kHz and 5 kHz impulses. Student's t-test, Cox regression analysis, and Kaplan-Meier survival analysis were performed, and a p<0.05 was accepted as statistically significant. Results: The mean age of 430 patients was 59 +/- 15 (10-92) years, and 54% of patients were male. By the end of the study, 125 (29%) patients died. Diabetes mellitus was observed in 46% of patients. Sixty-seven percent of patients used erythropoietin, and 41% used diuretics. The mean systolic blood pressure of patients before the dyalisis was 133 +/- 26 mmHg, and diastolic blood pressure was 79 +/- 12 mmHg. The IR values ranged between 73.2% and 94.1%. A multi-regression analysis that used the IR and included diabetes mellitus, age, gender, and albumin and hemoglobin levels showed that the mortality risk increased 16% (p<0.001). Evaluation using the quartiles showed decreased survival. Survival in the first quartile group was 42.8 months compared to 30.6 months in the last quartile group. Conclusion: The IR calculated using BIS data is a useful tool that can be employed to predict the survival in chronic HD patients. An early awareness of this increased mortality risk is important in terms of a close follow-up and appropriate treatment of these patients.

Yazar Hur, Ender
Gokalp, Cenk
Kose, Sennur
Duman, Elif
Magden, Kemal
Yildiz, Gursel
Toka, Bilal
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2999
Tek Biçim Adres 10.5152/turkjnephrol.2019.3126
Konu Başlıkları Bioimpedance
impedance ratio
survival
hemodialysis
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı TURKISH JOURNAL OF NEPHROLOGY
Dergi Cilt Bilgisi 28
Dergi Sayısı 1
Sayfalar 24 - 29
Yayın Yılı 2019
Eser Adı
[dc.title]
New Method to Predict Survival in Hemodialysis Patients Using the Impedance Ratio
Yazar
[dc.contributor.author]
Hur, Ender
Yazar
[dc.contributor.author]
Gokalp, Cenk
Yazar
[dc.contributor.author]
Kose, Sennur
Yazar
[dc.contributor.author]
Duman, Elif
Yazar
[dc.contributor.author]
Magden, Kemal
Yazar
[dc.contributor.author]
Yildiz, Gursel
Yazar
[dc.contributor.author]
Toka, Bilal
Yayın Yılı
[dc.date.issued]
2019
Yayıncı
[dc.publisher]
TURK NEFROLOJI DIYALIZ TRANSPLANTASYON DERGISI
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: Bioimpedance spectroscopy (BIS) can be used to determine hypervolemia and malnutrition in chronic hemodialysis (HD) patients. In this prospective observational study, we investigated the survival predictability of impedance ratio (IR) calculated by BIS in HD patients (Clinical Trials Gov Identifier: NCT01468363). Materials and Methods: A total of 430 chronic HD patients, out of 500 prevalent chronic HD patients from the city of Zonguldak who met the inclusion criteria, were included in the study. With a mean follow-up of 32.2 +/- 14.4 months, BIS was performed in all patients. The IR percentage (IR%) was calculated by dividing the resistance values using the 200 kHz and 5 kHz impulses. Student's t-test, Cox regression analysis, and Kaplan-Meier survival analysis were performed, and a p<0.05 was accepted as statistically significant. Results: The mean age of 430 patients was 59 +/- 15 (10-92) years, and 54% of patients were male. By the end of the study, 125 (29%) patients died. Diabetes mellitus was observed in 46% of patients. Sixty-seven percent of patients used erythropoietin, and 41% used diuretics. The mean systolic blood pressure of patients before the dyalisis was 133 +/- 26 mmHg, and diastolic blood pressure was 79 +/- 12 mmHg. The IR values ranged between 73.2% and 94.1%. A multi-regression analysis that used the IR and included diabetes mellitus, age, gender, and albumin and hemoglobin levels showed that the mortality risk increased 16% (p<0.001). Evaluation using the quartiles showed decreased survival. Survival in the first quartile group was 42.8 months compared to 30.6 months in the last quartile group. Conclusion: The IR calculated using BIS data is a useful tool that can be employed to predict the survival in chronic HD patients. An early awareness of this increased mortality risk is important in terms of a close follow-up and appropriate treatment of these patients.
Açıklama
[dc.description]
WOS: 000461206800006
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Bioimpedance
Konu Başlıkları
[dc.subject]
impedance ratio
Konu Başlıkları
[dc.subject]
survival
Konu Başlıkları
[dc.subject]
hemodialysis
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
2667-4440
İlk Sayfa Sayısı
[dc.identifier.startpage]
24
Son Sayfa Sayısı
[dc.identifier.endpage]
29
Dergi Adı
[dc.relation.journal]
TURKISH JOURNAL OF NEPHROLOGY
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
28
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.5152/turkjnephrol.2019.3126
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2999
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
35
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
15 Nisan 2024 06:50
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patients survival chronic months calculated analysis values follow-up mortality quartile included showed increased pressure mellitus performed between percent observed multi-regression Sixty-seven erythropoietin diuretics dyalisis diastolic ranged before systolic Objective diabetes useful employed predict awareness important
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