Tetanus in adults: results of the multicenter ID-IRI study

Tetanus is an acute, severe infection caused by a neurotoxin secreting bacterium. Various prognostic factors affecting mortality in tetanus patients have been described in the literature. In this study, we aimed to analyze the factors affecting mortality in hospitalized tetanus patients in a large case series. This retrospective multicenter study pooled data of tetanus patients from 25 medical centers. The hospitals participating in this study were the collaborating centers of the Infectious Diseases International Research Initiative (ID-IRI). Only adult patients over the age of 15 years with tetanus were included. The diagnosis of tetanus was made by the clinicians at the participant centers. Izmir Bozyaka Education and Research Hospital’s Review Board approved the study. Prognostic factors were analyzed by using the multivariate regression analysis method. In this study, 117 adult patients with tetanus were included. Of these, 79 (67.5%) patients survived and 38 (32.5%) patients died. Most of the deaths were observed in patients >60 years of age (60.5%). Generalized type of tetanus, presence of pain at the wound area, presence of generalized spasms, leukocytosis, high alanine aminotransferase (ALT) and C-reactive protein (CRP) values on admission, and the use of equine immunoglobulins in the treatment were found to be statistically associated with mortality (p < 0.05 for all). Here, we describe the prognostic factors for mortality in tetanus. Immunization seems to be the most critical point, considering the advanced age of our patients. A combination of laboratory and clinical parameters indicates mortality. Moreover, human immunoglobulins should be preferred over equine sera to increase survival. © 2017, Springer-Verlag Berlin Heidelberg.

Yazar Tosun S.
Batirel A.
Oluk A.I.
Aksoy F.
Puca E.
Bénézit F.
Ural S.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/7827
Tek Biçim Adres 10.1007/s10096-017-2954-3
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
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Dergi Adı European Journal of Clinical Microbiology and Infectious Diseases
Dergi Cilt Bilgisi 36
Dergi Sayısı 8
Sayfalar 1455 - 1462
Yayın Yılı 2017
Eser Adı
[dc.title]
Tetanus in adults: results of the multicenter ID-IRI study
Yazar
[dc.contributor.author]
Tosun S.
Yazar
[dc.contributor.author]
Batirel A.
Yazar
[dc.contributor.author]
Oluk A.I.
Yazar
[dc.contributor.author]
Aksoy F.
Yazar
[dc.contributor.author]
Puca E.
Yazar
[dc.contributor.author]
Bénézit F.
Yazar
[dc.contributor.author]
Ural S.
Yayın Yılı
[dc.date.issued]
2017
Yayıncı
[dc.publisher]
Springer Verlag
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Tetanus is an acute, severe infection caused by a neurotoxin secreting bacterium. Various prognostic factors affecting mortality in tetanus patients have been described in the literature. In this study, we aimed to analyze the factors affecting mortality in hospitalized tetanus patients in a large case series. This retrospective multicenter study pooled data of tetanus patients from 25 medical centers. The hospitals participating in this study were the collaborating centers of the Infectious Diseases International Research Initiative (ID-IRI). Only adult patients over the age of 15 years with tetanus were included. The diagnosis of tetanus was made by the clinicians at the participant centers. Izmir Bozyaka Education and Research Hospital’s Review Board approved the study. Prognostic factors were analyzed by using the multivariate regression analysis method. In this study, 117 adult patients with tetanus were included. Of these, 79 (67.5%) patients survived and 38 (32.5%) patients died. Most of the deaths were observed in patients >60 years of age (60.5%). Generalized type of tetanus, presence of pain at the wound area, presence of generalized spasms, leukocytosis, high alanine aminotransferase (ALT) and C-reactive protein (CRP) values on admission, and the use of equine immunoglobulins in the treatment were found to be statistically associated with mortality (p < 0.05 for all). Here, we describe the prognostic factors for mortality in tetanus. Immunization seems to be the most critical point, considering the advanced age of our patients. A combination of laboratory and clinical parameters indicates mortality. Moreover, human immunoglobulins should be preferred over equine sera to increase survival. © 2017, Springer-Verlag Berlin Heidelberg.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0934-9723
İlk Sayfa Sayısı
[dc.identifier.startpage]
1455
Son Sayfa Sayısı
[dc.identifier.endpage]
1462
Dergi Adı
[dc.relation.journal]
European Journal of Clinical Microbiology and Infectious Diseases
Dergi Sayısı
[dc.identifier.issue]
8
Dergi Cilt Bilgisi
[dc.identifier.volume]
36
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/s10096-017-2954-3
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7827
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
169
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
17 Temmuz 2024 22:34
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Tıklayınız
patients tetanus mortality factors centers immunoglobulins included equine Research affecting presence prognostic Generalized treatment generalized alanine spasms leukocytosis admission values protein C-reactive aminotransferase Tetanus statistically parameters indicates Moreover should preferred increase laboratory survival Springer-Verlag Berlin
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