The impact of obstructive sleep apnoea and nasal continuous positive airway pressure on circulating ischaemia-modified albumin concentrations

The aim of the present study was to evaluate the impact of obstructive sleep apnoea syndrome (OSAS) and the effects of nasal continuous positive airway pressure (CPAP) on circulating ischaemia-modified albumin (IMA) concentrations. The study included 97 newly diagnosed OSAS patients and 30 nonapnoeic controls. Blood samples were obtained in the morning after polysomnography. After 3 months of CPAP treatment, 31 patients with moderate-severe OSAS were reassessed for serum IMA concentrations. Significantly higher serum IMA concentrations were measured in the OSAS group than in the control group [0.518 ± 0.091 absorbance units (ABSU), 0.415 ± 0.068 ABSU, P < 0.001]. Serum IMA concentrations correlated significantly with the apnoea-hypopnoea index, mean SaO desaturation index, and C-reactive protein concentrations. Multiple logistic regression analyses showed that OSAS increased the serum IMA concentration independent of age, sex, body mass index, smoking habit, and cardiovascular disease. After 3 months of treatment with CPAP, OSAS patients had significantly lower serum IMA concentrations (0.555 ± 0.062 ABSU to 0.431 ± 0.063 ABSU, P < 0.001). The results showed that OSAS is associated with elevated concentrations of IMA, which can be reversed by effective CPAP treatment. © 2016 Firat Uygur et al.

Yazar Uygur F.
Tanriverdi H.
Can M.
Ornek T.
Erboy F.
Altinsoy B.
Atalay F.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/8115
Tek Biçim Adres 10.1155/2016/8907314
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Mediators of Inflammation
Dergi Cilt Bilgisi 2016
Sayfalar -
Yayın Yılı 2016
Eser Adı
[dc.title]
The impact of obstructive sleep apnoea and nasal continuous positive airway pressure on circulating ischaemia-modified albumin concentrations
Yazar
[dc.contributor.author]
Uygur F.
Yazar
[dc.contributor.author]
Tanriverdi H.
Yazar
[dc.contributor.author]
Can M.
Yazar
[dc.contributor.author]
Ornek T.
Yazar
[dc.contributor.author]
Erboy F.
Yazar
[dc.contributor.author]
Altinsoy B.
Yazar
[dc.contributor.author]
Atalay F.
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
Hindawi Limited
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
The aim of the present study was to evaluate the impact of obstructive sleep apnoea syndrome (OSAS) and the effects of nasal continuous positive airway pressure (CPAP) on circulating ischaemia-modified albumin (IMA) concentrations. The study included 97 newly diagnosed OSAS patients and 30 nonapnoeic controls. Blood samples were obtained in the morning after polysomnography. After 3 months of CPAP treatment, 31 patients with moderate-severe OSAS were reassessed for serum IMA concentrations. Significantly higher serum IMA concentrations were measured in the OSAS group than in the control group [0.518 ± 0.091 absorbance units (ABSU), 0.415 ± 0.068 ABSU, P < 0.001]. Serum IMA concentrations correlated significantly with the apnoea-hypopnoea index, mean SaO desaturation index, and C-reactive protein concentrations. Multiple logistic regression analyses showed that OSAS increased the serum IMA concentration independent of age, sex, body mass index, smoking habit, and cardiovascular disease. After 3 months of treatment with CPAP, OSAS patients had significantly lower serum IMA concentrations (0.555 ± 0.062 ABSU to 0.431 ± 0.063 ABSU, P < 0.001). The results showed that OSAS is associated with elevated concentrations of IMA, which can be reversed by effective CPAP treatment. © 2016 Firat Uygur et al.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0962-9351
Dergi Adı
[dc.relation.journal]
Mediators of Inflammation
Dergi Cilt Bilgisi
[dc.identifier.volume]
2016
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1155/2016/8907314
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/8115
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
23
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
18 Şubat 2024 23:50
Google Kontrol
Tıklayınız
concentrations patients treatment showed months significantly protein effective analyses regression logistic Multiple desaturation C-reactive reversed apnoea-hypopnoea correlated increased disease cardiovascular results independent concentration associated elevated smoking positive included albumin ischaemia-modified circulating (CPAP) pressure airway continuous
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms