Galectin-3: A biochemical marker to detect paroxysmal atrial fibrillation?

Purpose: Atrial fibrillation (AF) is the most common form of arrhythmia. AF leads to electrical remodelling and fibrosis of the atria; however, the mechanism(s) remain poorly understood. Galectin-3 is a potential mediator of cardiac fibrosis. The present study aimed to examine the relationship between serum galectin-3 levels and paroxysmal AF. Methods: Forty-six patients with paroxysmal AF and preserved left ventricular systolic function, and 38 age- and gender-matched control subjects, were involved in the study. Serum galectin-3 levels were analyzed with an enzyme-linked immunosorbent assay (ELISA). Results: Serum galectin-3 levels (median 1.38 ng/mL; 1.21 ng/mL-1.87 ng/mL; p < 0.001) were significantly elevated in patients with paroxysmal AF compared with the control. Left atrial diameter was significantly higher in patients with paroxysmal AF (41.2±3.0 mm vs. 39.6±3.3 mm). Left atrial diameter was found to be significantly correlated with serum galectin-3 levels in patients with paroxysmal AF (r= 0.378, p= 0.001). Conclusion: Serum galectin-3 levels are significantly elevated and significantly correlated with left atrial diameter in patients with paroxysmal AF. © 2016 CIM.

Yazar Selcoki Y.
Aydin H.I.
Celik T.H.
Isleyen A.
Erayman A.
Demircelik M.B.
Demirin H.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/5945
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Clinical and Investigative Medicine
Dergi Cilt Bilgisi 39
Dergi Sayısı 6
Sayfalar S197 - S203
Yayın Yılı 2016
Eser Adı
[dc.title]
Galectin-3: A biochemical marker to detect paroxysmal atrial fibrillation?
Yazar
[dc.contributor.author]
Selcoki Y.
Yazar
[dc.contributor.author]
Aydin H.I.
Yazar
[dc.contributor.author]
Celik T.H.
Yazar
[dc.contributor.author]
Isleyen A.
Yazar
[dc.contributor.author]
Erayman A.
Yazar
[dc.contributor.author]
Demircelik M.B.
Yazar
[dc.contributor.author]
Demirin H.
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
The Canadian Society for Clinical Investigation
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Purpose: Atrial fibrillation (AF) is the most common form of arrhythmia. AF leads to electrical remodelling and fibrosis of the atria; however, the mechanism(s) remain poorly understood. Galectin-3 is a potential mediator of cardiac fibrosis. The present study aimed to examine the relationship between serum galectin-3 levels and paroxysmal AF. Methods: Forty-six patients with paroxysmal AF and preserved left ventricular systolic function, and 38 age- and gender-matched control subjects, were involved in the study. Serum galectin-3 levels were analyzed with an enzyme-linked immunosorbent assay (ELISA). Results: Serum galectin-3 levels (median 1.38 ng/mL; 1.21 ng/mL-1.87 ng/mL; p < 0.001) were significantly elevated in patients with paroxysmal AF compared with the control. Left atrial diameter was significantly higher in patients with paroxysmal AF (41.2±3.0 mm vs. 39.6±3.3 mm). Left atrial diameter was found to be significantly correlated with serum galectin-3 levels in patients with paroxysmal AF (r= 0.378, p= 0.001). Conclusion: Serum galectin-3 levels are significantly elevated and significantly correlated with left atrial diameter in patients with paroxysmal AF. © 2016 CIM.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0147958X
İlk Sayfa Sayısı
[dc.identifier.startpage]
S197
Son Sayfa Sayısı
[dc.identifier.endpage]
S203
Dergi Adı
[dc.relation.journal]
Clinical and Investigative Medicine
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
39
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5945
Görüntülenme Sayısı ( Şehir )
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Görüntülenme
12
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
17 Ocak 2024 20:39
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paroxysmal galectin-3 significantly patients levels diameter atrial fibrosis elevated control correlated (median ng/mL-1 Results Purpose compared Conclusion higher (ELISA) gender-matched immunosorbent remodelling Galectin-3 understood poorly remain mechanism(s) however electrical potential arrhythmia common fibrillation Atrial mediator
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