The association between insulin resistance and hepatic fibrosis in patients with chronic hepatitis C: An observational, multicenter study in Turkey

Background/Aims: To evaluate the association between insulin resistance and hepatic fibrosis in patients with chronic hepatitis C.Materials and Methods: A total of 104 chronic hepatitis C patients were included in this non-interventional, open-label, observational, multicenter, cross-sectional study conducted at 20 gastroenterology clinics in Turkey. The primary end point was the correlation between stage of hepatic fibrosis and insulin resistance evaluated via the homeostasis model of assessment-insulin resistance index. Confounders of hepatic fibrosis and insulin resistance were the secondary end points.Results: The mean age of patients was 52.8 years; 65.4% were female. Type 2 diabetes was present in 6.8% and insulin resistance noted in 38.0% of patients. Further, 45.7% of the patients had mild (A0/A1) and the remaining had moderate/severe (A2/A3) hepatic necroinflammatory activity. Patient distribution according to Metavir fibrosis stage was as follows: F0/F1 (57.0%); F2 (6.5%); F3 (23.7%); and F4 (12.9%). A univariate analysis revealed significant positive correlations between Metavir fibrosis stage and insulin resistance (r=0.297; p=0.007). Logistic regression analysis showed that significant predictors of insulin resistance were high alanine transaminase levels (odds ratio, 0.97; 95% confidence interval, 0.944-0.997) and liver fibrosis stage (odds ratio, 0.114; 95% confidence interval, 0.021-0.607).Conclusion: Our findings revealed significant associations between insulin resistance and hepatic fibrosis. © 2014 by The Turkish Society of Gastroenterology.

Yazar Dökmeci A.
Üstünda? Y.
Hulagu S.
Tuncer I.
Akdo?an M.
Demirsoy H.
Köklü S.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/7850
Tek Biçim Adres 10.5152/tjg.2014.7829
Konu Başlıkları Chronic hepatitis C
Hepatic fibrosis
Insulin resistance
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı Turkish Journal of Gastroenterology
Dergi Cilt Bilgisi 25
Dergi Sayısı 5
Sayfalar 546 - 552
Yayın Yılı 2014
Eser Adı
[dc.title]
The association between insulin resistance and hepatic fibrosis in patients with chronic hepatitis C: An observational, multicenter study in Turkey
Yazar
[dc.contributor.author]
Dökmeci A.
Yazar
[dc.contributor.author]
Üstünda? Y.
Yazar
[dc.contributor.author]
Hulagu S.
Yazar
[dc.contributor.author]
Tuncer I.
Yazar
[dc.contributor.author]
Akdo?an M.
Yazar
[dc.contributor.author]
Demirsoy H.
Yazar
[dc.contributor.author]
Köklü S.
Yayın Yılı
[dc.date.issued]
2014
Yayıncı
[dc.publisher]
Turkish Society of Gastroenterology
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background/Aims: To evaluate the association between insulin resistance and hepatic fibrosis in patients with chronic hepatitis C.Materials and Methods: A total of 104 chronic hepatitis C patients were included in this non-interventional, open-label, observational, multicenter, cross-sectional study conducted at 20 gastroenterology clinics in Turkey. The primary end point was the correlation between stage of hepatic fibrosis and insulin resistance evaluated via the homeostasis model of assessment-insulin resistance index. Confounders of hepatic fibrosis and insulin resistance were the secondary end points.Results: The mean age of patients was 52.8 years; 65.4% were female. Type 2 diabetes was present in 6.8% and insulin resistance noted in 38.0% of patients. Further, 45.7% of the patients had mild (A0/A1) and the remaining had moderate/severe (A2/A3) hepatic necroinflammatory activity. Patient distribution according to Metavir fibrosis stage was as follows: F0/F1 (57.0%); F2 (6.5%); F3 (23.7%); and F4 (12.9%). A univariate analysis revealed significant positive correlations between Metavir fibrosis stage and insulin resistance (r=0.297; p=0.007). Logistic regression analysis showed that significant predictors of insulin resistance were high alanine transaminase levels (odds ratio, 0.97; 95% confidence interval, 0.944-0.997) and liver fibrosis stage (odds ratio, 0.114; 95% confidence interval, 0.021-0.607).Conclusion: Our findings revealed significant associations between insulin resistance and hepatic fibrosis. © 2014 by The Turkish Society of Gastroenterology.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Chronic hepatitis C
Konu Başlıkları
[dc.subject]
Hepatic fibrosis
Konu Başlıkları
[dc.subject]
Insulin resistance
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1300-4948
İlk Sayfa Sayısı
[dc.identifier.startpage]
546
Son Sayfa Sayısı
[dc.identifier.endpage]
552
Dergi Adı
[dc.relation.journal]
Turkish Journal of Gastroenterology
Dergi Sayısı
[dc.identifier.issue]
5
Dergi Cilt Bilgisi
[dc.identifier.volume]
25
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.5152/tjg.2014.7829
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7850
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
15
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 07:20
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Tıklayınız
resistance fibrosis insulin hepatic patients between significant interval confidence analysis revealed hepatitis chronic Metavir univariate positive correlations follows according Background/Aims Gastroenterology Society Turkish associations findings Conclusion Logistic Patient levels transaminase alanine predictors showed regression distribution
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