Does skip metastasis or other lymph node parameters have additional effects on survival of patients undergoing radical cystectomy for bladder cancer?

Purpose: To investigate the effects of lymph node metastasis, skip metastasis, and other factors related to lymph node status on survival in patients who underwent radical cystectomy (RC) and extended lymph node dissection (eLND). Materials and Methods: RC and eLND were performed in 85 patients with a diagnosis of bladder cancer. Disease-free survival (DFS) and overall survival (OS) were determined by using a Cox proportional hazards model that included the number of excised lymph nodes, the presence of pathological lymph node metastasis, the anatomical level of positive nodes, the number of positive lymph nodes, lymph node density, and the presence of skip metastasis. Results: The mean number of lymph nodes removed per patient was 29.4±9.3. Lymph node positivity was detected in 85 patients (34.1%). The mean follow-up duration was 44.9±27.4 months (2–93 months). Five-year estimated OS and DFS for the 85 patients were 62.6% and 57%, respectively. Three of 29 lymph node-positive patients (10.3%) had skip metastasis. Only lymph node positivity had a significant effect on 5-year OS and DFS (p<0.001). No difference in OS and DFS was found between the three patients with skip metastasis and other lymph node-positive patients. Other factors related to lymph node status had no significant effect on 5-year OS and DFS. Conclusions: No factors related to lymph node status predict DFS and OS, except for lymph node positivity. OS and DFS were comparable between patients with skip metastasis and other lymph node-positive patients. © The Korean Urological Association, 2015.

Yazar Ugurlu O.
Baltaci S.
Aslan G.
Can C.
Cal C.
Elhan A.
Turkeri L.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/5177
Tek Biçim Adres 10.4111/kju.2015.56.5.357
Konu Başlıkları Lymph node excision
Treatment outcome
Urinary bladder neoplasms
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Korean Journal of Urology
Dergi Cilt Bilgisi 56
Dergi Sayısı 5
Sayfalar 357 - 364
Yayın Yılı 2015
Eser Adı
[dc.title]
Does skip metastasis or other lymph node parameters have additional effects on survival of patients undergoing radical cystectomy for bladder cancer?
Yazar
[dc.contributor.author]
Ugurlu O.
Yazar
[dc.contributor.author]
Baltaci S.
Yazar
[dc.contributor.author]
Aslan G.
Yazar
[dc.contributor.author]
Can C.
Yazar
[dc.contributor.author]
Cal C.
Yazar
[dc.contributor.author]
Elhan A.
Yazar
[dc.contributor.author]
Turkeri L.
Yayın Yılı
[dc.date.issued]
2015
Yayıncı
[dc.publisher]
Korean Urological Association
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Purpose: To investigate the effects of lymph node metastasis, skip metastasis, and other factors related to lymph node status on survival in patients who underwent radical cystectomy (RC) and extended lymph node dissection (eLND). Materials and Methods: RC and eLND were performed in 85 patients with a diagnosis of bladder cancer. Disease-free survival (DFS) and overall survival (OS) were determined by using a Cox proportional hazards model that included the number of excised lymph nodes, the presence of pathological lymph node metastasis, the anatomical level of positive nodes, the number of positive lymph nodes, lymph node density, and the presence of skip metastasis. Results: The mean number of lymph nodes removed per patient was 29.4±9.3. Lymph node positivity was detected in 85 patients (34.1%). The mean follow-up duration was 44.9±27.4 months (2–93 months). Five-year estimated OS and DFS for the 85 patients were 62.6% and 57%, respectively. Three of 29 lymph node-positive patients (10.3%) had skip metastasis. Only lymph node positivity had a significant effect on 5-year OS and DFS (p<0.001). No difference in OS and DFS was found between the three patients with skip metastasis and other lymph node-positive patients. Other factors related to lymph node status had no significant effect on 5-year OS and DFS. Conclusions: No factors related to lymph node status predict DFS and OS, except for lymph node positivity. OS and DFS were comparable between patients with skip metastasis and other lymph node-positive patients. © The Korean Urological Association, 2015.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Lymph node excision
Konu Başlıkları
[dc.subject]
Treatment outcome
Konu Başlıkları
[dc.subject]
Urinary bladder neoplasms
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
2005-6737
İlk Sayfa Sayısı
[dc.identifier.startpage]
357
Son Sayfa Sayısı
[dc.identifier.endpage]
364
Dergi Adı
[dc.relation.journal]
Korean Journal of Urology
Dergi Sayısı
[dc.identifier.issue]
5
Dergi Cilt Bilgisi
[dc.identifier.volume]
56
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.4111/kju.2015.56.5.357
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5177
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
10
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 12:38
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Tıklayınız
patients metastasis positivity node-positive number survival related factors status presence significant effect 5-year positive between months) months Urological Association Five-year estimated duration follow-up (2–93 comparable Korean predict Conclusions difference except respectively Purpose (eLND) Disease-free cancer
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