The effects of nitrous oxide on vitamin B12 and homocysteine: Levels in methyltetrahydrofolate reductase gene mutation

Background: We aimed to investigate the effects of nitrous oxide on plasma total homocysteine and vitamin B12 levels in patients with or without methyltetrahydrofolate reductase (MTHRF) gene mutation. Methods: After obtaining the ethics committee approval and written informed consents of patients, 93 patients between 18-70 years of age scheduled for surgery anticipated to last 1-4 hours were enrolled in the study. Patients with contraindications for nitrous oxide use were excluded. Preoperatively, blood samples were obtained from all patients for the determination of MTHFR gene mutation. Anesthesia induction was achieved with 3 mg.kg-1 of propofol and 1 µg.kg-1 of fentanyl. Anesthesia maintenance was performed with sevoflurane and with a carrier gas composed of 40 % O2 and 60 % N2O. Venous blood samples were obtained after venous canulation, and 24 hours after extubation for the analysis of plasma total homocysteine, vitamin B12 levels. Results: Eighty-one patients were included in the study. Postoperative vitamin B12 levels were found to be significantly lower when compared with their preoperative levels (p<0.05). It was found that MTHRF gene polymorphism had no significant effect on postoperative plasma total homocysteine and serum vitamin B12 levels (p>0.05). Postoperative plasma total homocysteine levels were found to be significantly different between patients with operation times under and over 3 hours (p=0.028). Conclusions: We conclude that MTHRF gene polymorphism had no significant effects on postoperative plasma total homocysteine levels. However, we found that homocysteine levels might rise in patients who received general anesthesia with nitrous oxide for longer than 3 hours (Tab. 7, Ref. 26). Full Text in PDF www.elis.sk.

Yazar Hakimoglu S.
Hanci V.
Hakimoglu Y.
Cicek S.
Yurtlu S.
Okyay R.D.
Ayoglu H.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/8038
Tek Biçim Adres 10.4149/BLL_2013_067
Konu Başlıkları General anesthesia
Homocysteine
Methyltetrahydrofolate reductase
Nitrous oxide
Vitamin B12
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı Bratislava Medical Journal
Dergi Cilt Bilgisi 114
Dergi Sayısı 6
Sayfalar 317 - 322
Yayın Yılı 2013
Eser Adı
[dc.title]
The effects of nitrous oxide on vitamin B12 and homocysteine: Levels in methyltetrahydrofolate reductase gene mutation
Yazar
[dc.contributor.author]
Hakimoglu S.
Yazar
[dc.contributor.author]
Hanci V.
Yazar
[dc.contributor.author]
Hakimoglu Y.
Yazar
[dc.contributor.author]
Cicek S.
Yazar
[dc.contributor.author]
Yurtlu S.
Yazar
[dc.contributor.author]
Okyay R.D.
Yazar
[dc.contributor.author]
Ayoglu H.
Yayın Yılı
[dc.date.issued]
2013
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: We aimed to investigate the effects of nitrous oxide on plasma total homocysteine and vitamin B12 levels in patients with or without methyltetrahydrofolate reductase (MTHRF) gene mutation. Methods: After obtaining the ethics committee approval and written informed consents of patients, 93 patients between 18-70 years of age scheduled for surgery anticipated to last 1-4 hours were enrolled in the study. Patients with contraindications for nitrous oxide use were excluded. Preoperatively, blood samples were obtained from all patients for the determination of MTHFR gene mutation. Anesthesia induction was achieved with 3 mg.kg-1 of propofol and 1 µg.kg-1 of fentanyl. Anesthesia maintenance was performed with sevoflurane and with a carrier gas composed of 40 % O2 and 60 % N2O. Venous blood samples were obtained after venous canulation, and 24 hours after extubation for the analysis of plasma total homocysteine, vitamin B12 levels. Results: Eighty-one patients were included in the study. Postoperative vitamin B12 levels were found to be significantly lower when compared with their preoperative levels (p<0.05). It was found that MTHRF gene polymorphism had no significant effect on postoperative plasma total homocysteine and serum vitamin B12 levels (p>0.05). Postoperative plasma total homocysteine levels were found to be significantly different between patients with operation times under and over 3 hours (p=0.028). Conclusions: We conclude that MTHRF gene polymorphism had no significant effects on postoperative plasma total homocysteine levels. However, we found that homocysteine levels might rise in patients who received general anesthesia with nitrous oxide for longer than 3 hours (Tab. 7, Ref. 26). Full Text in PDF www.elis.sk.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
General anesthesia
Konu Başlıkları
[dc.subject]
Homocysteine
Konu Başlıkları
[dc.subject]
Methyltetrahydrofolate reductase
Konu Başlıkları
[dc.subject]
Nitrous oxide
Konu Başlıkları
[dc.subject]
Vitamin B12
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0006-9248
Sponsor YAYINCI
[dc.description.sponsorship]
Karaelmas University Scientific Research
İlk Sayfa Sayısı
[dc.identifier.startpage]
317
Son Sayfa Sayısı
[dc.identifier.endpage]
322
Dergi Adı
[dc.relation.journal]
Bratislava Medical Journal
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
114
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.4149/BLL_2013_067
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/8038
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
95
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
18 Mayıs 2024 17:54
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Tıklayınız
levels patients homocysteine plasma vitamin nitrous polymorphism Anesthesia significant postoperative obtained between significantly effects Postoperative mutation samples compared included preoperative effect Eighty-one Background general longer anesthesia received However conclude Conclusions analysis operation different Results fentanyl
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