Effects of aminoguanidine and antioxidant erdosteine on bleomycin-induced lung fibrosis in rats

Reactive oxygen and nitrogen species have been implicated in the pathogenesis of bleomycin-induced lung fibrosis. The effects of aminoguanidine and erdosteine on the bleomycin-induced lung fibrosis were evaluated in rats. The animals were placed into five groups: Vehicle + vehicle, vehicle + bleomycin (2.5 U/kg), bleomycin + aminoguanidine (200 mg/kg), bleomycin + erdosteine (10 mg/kg), and bleomycin + erdosteine + aminoguanidine. Bleomycin administration resulted in prominent lung fibrosis as measured by lung hydroxyproline content and lung histology, which is completely prevented by erdosteine and aminoguanidine. A strong staining for nitro tyrosine antibody in lung tissue and increased levels of lung NO were found in bleomycin group, that were significantly reduced by aminoguanidine and erdosteine. Aminoguanidine and erdosteine significantly prevented depletion of superoxide dismutase and glutathione peroxidase and elevated myeloperoxidase activities, malondialdehyde level in lung tissue produced by bleomycin. Data presented here indicate that aminoguanidine and erdosteine prevented bleomycin-induced lung fibrosis and that nitric oxide mediated tyrosine nitration of proteins plays a significant role in the pathogenesis of bleomycin-induced lung fibrosis. Also our data suggest that antifibrotic affect of antioxidants may be due to their inhibitory effect on nitric oxide generation in this model. © 2004 Elsevier Inc. All rights reserved.

Yazar Yildirim Z.
Turkoz Y.
Kotuk M.
Armutcu F.
Gurel A.
Iraz M.
Ozen S.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/5429
Tek Biçim Adres 10.1016/j.niox.2004.07.011
Konu Başlıkları Aminoguanidin
Bleomycin
Erdosteine
Lung fibrosis
Nitric oxide
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Nitric Oxide - Biology and Chemistry
Dergi Cilt Bilgisi 11
Dergi Sayısı 2
Sayfalar 156 - 165
Yayın Yılı 2004
Eser Adı
[dc.title]
Effects of aminoguanidine and antioxidant erdosteine on bleomycin-induced lung fibrosis in rats
Yazar
[dc.contributor.author]
Yildirim Z.
Yazar
[dc.contributor.author]
Turkoz Y.
Yazar
[dc.contributor.author]
Kotuk M.
Yazar
[dc.contributor.author]
Armutcu F.
Yazar
[dc.contributor.author]
Gurel A.
Yazar
[dc.contributor.author]
Iraz M.
Yazar
[dc.contributor.author]
Ozen S.
Yayın Yılı
[dc.date.issued]
2004
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Reactive oxygen and nitrogen species have been implicated in the pathogenesis of bleomycin-induced lung fibrosis. The effects of aminoguanidine and erdosteine on the bleomycin-induced lung fibrosis were evaluated in rats. The animals were placed into five groups: Vehicle + vehicle, vehicle + bleomycin (2.5 U/kg), bleomycin + aminoguanidine (200 mg/kg), bleomycin + erdosteine (10 mg/kg), and bleomycin + erdosteine + aminoguanidine. Bleomycin administration resulted in prominent lung fibrosis as measured by lung hydroxyproline content and lung histology, which is completely prevented by erdosteine and aminoguanidine. A strong staining for nitro tyrosine antibody in lung tissue and increased levels of lung NO were found in bleomycin group, that were significantly reduced by aminoguanidine and erdosteine. Aminoguanidine and erdosteine significantly prevented depletion of superoxide dismutase and glutathione peroxidase and elevated myeloperoxidase activities, malondialdehyde level in lung tissue produced by bleomycin. Data presented here indicate that aminoguanidine and erdosteine prevented bleomycin-induced lung fibrosis and that nitric oxide mediated tyrosine nitration of proteins plays a significant role in the pathogenesis of bleomycin-induced lung fibrosis. Also our data suggest that antifibrotic affect of antioxidants may be due to their inhibitory effect on nitric oxide generation in this model. © 2004 Elsevier Inc. All rights reserved.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Aminoguanidin
Konu Başlıkları
[dc.subject]
Bleomycin
Konu Başlıkları
[dc.subject]
Erdosteine
Konu Başlıkları
[dc.subject]
Lung fibrosis
Konu Başlıkları
[dc.subject]
Nitric oxide
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1089-8603
İlk Sayfa Sayısı
[dc.identifier.startpage]
156
Son Sayfa Sayısı
[dc.identifier.endpage]
165
Dergi Adı
[dc.relation.journal]
Nitric Oxide - Biology and Chemistry
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
11
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.niox.2004.07.011
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/5429
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
28
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 07:09
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Tıklayınız
erdosteine aminoguanidine bleomycin fibrosis bleomycin-induced prevented tyrosine tissue nitric mg/kg) vehicle pathogenesis significantly mediated nitration proteins Reactive malondialdehyde indicate presented produced activities myeloperoxidase elevated peroxidase significant effect reserved rights Elsevier generation inhibitory dismutase antioxidants affect
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