Hypervolemia for hypertension pathophysiology: A population-based study

Objectives. Hypertension and hypervolemia relationship was proven among renal disease, although it is not known in normal population. Present study determines the fluid distribution defects in relation to blood pressure. Material and Methods. In a population-based survey in Turkey demographics, height, weight, blood pressure, urine analysis, and serum creatinine measurements were recorded. Bioimpedance measured with the Body Composition Monitor. Results. Total 2034 population of 71.6% male, mean age 47 ± 12.6 (18-89) years, systolic blood pressure (SBP) 134.7 ± 20, diastolic blood pressure 77.9 ± 11.6mmHg. Body mass index (BMI) was 28.5 ± 4.5 (15.8-50.6) kg/m2; overhydration was 0.05 ± 1.05 L. There was a correlation between extracellular water (ECW)/height and SBP (r = 0.21, P < 0.001). Receiver operating characteristic (ROC) curve with the performance of 0.60 (P < 0.001) that showed cut-off value of ECW/height was 10.06 L/m, with the 69% sensitivity and 45% specificity for SBP: 140mmHg values. Risk factors for high SBP were increase of ECW/Height, age, BMI and presence of diabetes. ECW/height, SBP, and fat tissue index (FTI) increased in BMI categories (low, normal, and obese) and in diabetics. SBP and FTI were lower in smokers. Conclusions. High blood pressure may be accompanied by increased extracellular volume indices. In the future volume status assessment could be of use in evaluating the effectiveness of pharmacological intervention in the treatment of hypertension. Copyright © 2014 Ender Hür et al.

Yazar Hür E.
Özişik M.
Ural C.
Yildiz G.
Ma?den K.
Köse S.B.
Köktürk F.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/6128
Tek Biçim Adres 10.1155/2014/895401
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
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WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı BioMed Research International
Dergi Cilt Bilgisi 2014
Sayfalar -
Yayın Yılı 2014
Eser Adı
[dc.title]
Hypervolemia for hypertension pathophysiology: A population-based study
Yazar
[dc.contributor.author]
Hür E.
Yazar
[dc.contributor.author]
Özişik M.
Yazar
[dc.contributor.author]
Ural C.
Yazar
[dc.contributor.author]
Yildiz G.
Yazar
[dc.contributor.author]
Ma?den K.
Yazar
[dc.contributor.author]
Köse S.B.
Yazar
[dc.contributor.author]
Köktürk F.
Yayın Yılı
[dc.date.issued]
2014
Yayıncı
[dc.publisher]
Hindawi Limited
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objectives. Hypertension and hypervolemia relationship was proven among renal disease, although it is not known in normal population. Present study determines the fluid distribution defects in relation to blood pressure. Material and Methods. In a population-based survey in Turkey demographics, height, weight, blood pressure, urine analysis, and serum creatinine measurements were recorded. Bioimpedance measured with the Body Composition Monitor. Results. Total 2034 population of 71.6% male, mean age 47 ± 12.6 (18-89) years, systolic blood pressure (SBP) 134.7 ± 20, diastolic blood pressure 77.9 ± 11.6mmHg. Body mass index (BMI) was 28.5 ± 4.5 (15.8-50.6) kg/m2; overhydration was 0.05 ± 1.05 L. There was a correlation between extracellular water (ECW)/height and SBP (r = 0.21, P < 0.001). Receiver operating characteristic (ROC) curve with the performance of 0.60 (P < 0.001) that showed cut-off value of ECW/height was 10.06 L/m, with the 69% sensitivity and 45% specificity for SBP: 140mmHg values. Risk factors for high SBP were increase of ECW/Height, age, BMI and presence of diabetes. ECW/height, SBP, and fat tissue index (FTI) increased in BMI categories (low, normal, and obese) and in diabetics. SBP and FTI were lower in smokers. Conclusions. High blood pressure may be accompanied by increased extracellular volume indices. In the future volume status assessment could be of use in evaluating the effectiveness of pharmacological intervention in the treatment of hypertension. Copyright © 2014 Ender Hür et al.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
2314-6133
Dergi Adı
[dc.relation.journal]
BioMed Research International
Dergi Cilt Bilgisi
[dc.identifier.volume]
2014
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1155/2014/895401
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/6128
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
12
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Nisan 2024 03:20
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pressure volume extracellular increased ECW/height normal population showed Receiver values operating characteristic 140mmHg factors specificity performance sensitivity cut-off Objectives treatment assessment evaluating effectiveness pharmacological intervention hypertension future Copyright status indices increase ECW/Height presence diabetes tissue
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