Is Xanthine oxidase activity in polycystic ovary syndrome associated with inflammatory and cardiovascular risk factors?

The aim of this study is to examine women with polycystic ovary syndrome (PCOS) to determine the relationship between xanthine oxidase (XO) and oxidative stress, inflammatory status, and various clinical and biochemical parameters. In this cross-sectional study a total of 83 women including 45 PCOS patients and 38 healthy women were enrolled. We collected blood samples for XO and superoxide dismutase (SOD) activity, hormone levels, cholesterol values, and inflammatory markers. Body mass index (BMI) , waist-to-hip ratio (WHR), and blood pressure were assessed. Blood samples were taken for hormonal levels, cholesterol levels, fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostatic model assessment-insulin resistance (HOMA-IR) index, quantitative insulin sensitivity check index (QUICKI), C-reactive protein (CRP), white blood cell and neutrophil counts, XO and SOD activities. The basal hormone levels, triglyceride (TG) levels, TG/HDL-C (high density lipoprotein-cholesterol) ratios FPG, FPI and HOMA-IR levels were higher in PCOS patients compared to controls (p < 0.05). Platelet and plateletcrit (PCT) values, CRP, and XO activity were significantly increased, however SOD activity was decreased in PCOS patients (p < 0.001). XO activity was positively correlated with LH/FSH and TG/HDL ratios, CRP, PCT, FPG, FPI, and HOMA-IR, and negatively correlated with QUICKI levels. In conclusion, XO is a useful marker to assess oxidative stress in PCOS patients. Positive correlations between XO and inflammatory markers and cardiovascular disease risk factors suggest that XO plays an important role in the pathogenesis of PCOS and its metabolic complications. © 2016.

Yazar Isik H.
Aynioglu O.
Timur H.
Sahbaz A.
Harma M.
Can M.
Guven B.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/6411
Tek Biçim Adres 10.1016/j.jri.2016.06.002
Konu Başlıkları Cardiovascular risk
Inflammation
PCOS
Xanthine oxidase activity
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Journal of Reproductive Immunology
Dergi Cilt Bilgisi 116
Sayfalar 98 - 103
Yayın Yılı 2016
Eser Adı
[dc.title]
Is Xanthine oxidase activity in polycystic ovary syndrome associated with inflammatory and cardiovascular risk factors?
Yazar
[dc.contributor.author]
Isik H.
Yazar
[dc.contributor.author]
Aynioglu O.
Yazar
[dc.contributor.author]
Timur H.
Yazar
[dc.contributor.author]
Sahbaz A.
Yazar
[dc.contributor.author]
Harma M.
Yazar
[dc.contributor.author]
Can M.
Yazar
[dc.contributor.author]
Guven B.
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
Elsevier Ireland Ltd
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
The aim of this study is to examine women with polycystic ovary syndrome (PCOS) to determine the relationship between xanthine oxidase (XO) and oxidative stress, inflammatory status, and various clinical and biochemical parameters. In this cross-sectional study a total of 83 women including 45 PCOS patients and 38 healthy women were enrolled. We collected blood samples for XO and superoxide dismutase (SOD) activity, hormone levels, cholesterol values, and inflammatory markers. Body mass index (BMI) , waist-to-hip ratio (WHR), and blood pressure were assessed. Blood samples were taken for hormonal levels, cholesterol levels, fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostatic model assessment-insulin resistance (HOMA-IR) index, quantitative insulin sensitivity check index (QUICKI), C-reactive protein (CRP), white blood cell and neutrophil counts, XO and SOD activities. The basal hormone levels, triglyceride (TG) levels, TG/HDL-C (high density lipoprotein-cholesterol) ratios FPG, FPI and HOMA-IR levels were higher in PCOS patients compared to controls (p < 0.05). Platelet and plateletcrit (PCT) values, CRP, and XO activity were significantly increased, however SOD activity was decreased in PCOS patients (p < 0.001). XO activity was positively correlated with LH/FSH and TG/HDL ratios, CRP, PCT, FPG, FPI, and HOMA-IR, and negatively correlated with QUICKI levels. In conclusion, XO is a useful marker to assess oxidative stress in PCOS patients. Positive correlations between XO and inflammatory markers and cardiovascular disease risk factors suggest that XO plays an important role in the pathogenesis of PCOS and its metabolic complications. © 2016.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Cardiovascular risk
Konu Başlıkları
[dc.subject]
Inflammation
Konu Başlıkları
[dc.subject]
PCOS
Konu Başlıkları
[dc.subject]
Xanthine oxidase activity
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0165-0378
İlk Sayfa Sayısı
[dc.identifier.startpage]
98
Son Sayfa Sayısı
[dc.identifier.endpage]
103
Dergi Adı
[dc.relation.journal]
Journal of Reproductive Immunology
Dergi Cilt Bilgisi
[dc.identifier.volume]
116
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.jri.2016.06.002
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/6411
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
79
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
18 Mayıs 2024 20:58
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levels patients activity inflammatory samples ratios correlated hormone insulin HOMA-IR cholesterol values markers fasting plasma oxidative stress between pathogenesis Platelet metabolic plateletcrit marker complications controls compared higher lipoprotein-cholesterol) density TG/HDL-C triglyceride increased significantly LH/FSH Positive
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