Comparison of the diagnostic value of different lymphocyte subpopulations in bronchoalveolar lavage fluid in patients with biopsy proven sarcoidosis

Background: Bronchoalveolar lavage is considered a helpful tool in the diagnosis of diffuse parenchimal lung diseases such as sarcoidosis. CD4/CD8 ratio is higly specific but not sensitive to distinguish sarcoidosis and other intestitial lung diseases. We aimed to compare the diagnostic value of CD4/CD8 ratio and other lmphocyte subpopulations such as CD3+16+56, CD103+, CD4+CD103+, CD8+CD103+ in bronchoalveolar lavage to distinguish sarcoidosis and other nonsarcoidosis interstitial lung diseases. Methods: Using the bronchoscopy records from 2006 to 2013, we evaluated 68 patients with biopsy proven sarcoidosis and 72 patients with clinicoradiological and/or biopsy proven diffuse parenchimal lung diseases. Cut off values, sensitivity and specificity were given for aforementioned parameters. Results: Bronchoalveolar lavage CD4/CD8 ratio, CD4+ T lymphocyte percentage, CD4+103+, CD3+CD103-, CD8+CD103+/CD103+ ratio were significantly higher in sarcoidosis than other diffuse parenchimal lung diseases whereas CD3+103+, CD3+16+56+, CD8+, CD8+CD103+, CD8+CD103+/CD8+ were significantly lower. Best cut off value of CD4/CD8 was 1.34 with sensitivity and specificity 76.4%, 79.4% respectively. The cut off values of CD4/CD8 of >3.5 and >2.5 had specificity 95.9% and 95.3%, respectively and sensitivity 52%, 41 %, respectively. Conclusion: CD4/CD8 ratio is highly specific but not sensitive for sarcoidosis diagnosis. Thus, BAL flow cytometry is not diagnostic alone without appropriate clinicoradiological and/or histopathological findings. © Mattioli 1885.

Yazar Tanriverdi H.
Uygur F.
Örnek T.
Erboy F.
Altinsoy B.
Atalay F.
Büyükuysal M.Ç.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/4840
Konu Başlıkları Bronchoalveolar lavage
CD103+
CD4/CD8
Sarcoidosis
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Sarcoidosis Vasculitis and Diffuse Lung Diseases
Dergi Cilt Bilgisi 32
Dergi Sayısı 4
Sayfalar 305 - 312
Yayın Yılı 2015
Eser Adı
[dc.title]
Comparison of the diagnostic value of different lymphocyte subpopulations in bronchoalveolar lavage fluid in patients with biopsy proven sarcoidosis
Yazar
[dc.contributor.author]
Tanriverdi H.
Yazar
[dc.contributor.author]
Uygur F.
Yazar
[dc.contributor.author]
Örnek T.
Yazar
[dc.contributor.author]
Erboy F.
Yazar
[dc.contributor.author]
Altinsoy B.
Yazar
[dc.contributor.author]
Atalay F.
Yazar
[dc.contributor.author]
Büyükuysal M.Ç.
Yayın Yılı
[dc.date.issued]
2015
Yayıncı
[dc.publisher]
Mattioli 1885
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: Bronchoalveolar lavage is considered a helpful tool in the diagnosis of diffuse parenchimal lung diseases such as sarcoidosis. CD4/CD8 ratio is higly specific but not sensitive to distinguish sarcoidosis and other intestitial lung diseases. We aimed to compare the diagnostic value of CD4/CD8 ratio and other lmphocyte subpopulations such as CD3+16+56, CD103+, CD4+CD103+, CD8+CD103+ in bronchoalveolar lavage to distinguish sarcoidosis and other nonsarcoidosis interstitial lung diseases. Methods: Using the bronchoscopy records from 2006 to 2013, we evaluated 68 patients with biopsy proven sarcoidosis and 72 patients with clinicoradiological and/or biopsy proven diffuse parenchimal lung diseases. Cut off values, sensitivity and specificity were given for aforementioned parameters. Results: Bronchoalveolar lavage CD4/CD8 ratio, CD4+ T lymphocyte percentage, CD4+103+, CD3+CD103-, CD8+CD103+/CD103+ ratio were significantly higher in sarcoidosis than other diffuse parenchimal lung diseases whereas CD3+103+, CD3+16+56+, CD8+, CD8+CD103+, CD8+CD103+/CD8+ were significantly lower. Best cut off value of CD4/CD8 was 1.34 with sensitivity and specificity 76.4%, 79.4% respectively. The cut off values of CD4/CD8 of >3.5 and >2.5 had specificity 95.9% and 95.3%, respectively and sensitivity 52%, 41 %, respectively. Conclusion: CD4/CD8 ratio is highly specific but not sensitive for sarcoidosis diagnosis. Thus, BAL flow cytometry is not diagnostic alone without appropriate clinicoradiological and/or histopathological findings. © Mattioli 1885.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Bronchoalveolar lavage
Konu Başlıkları
[dc.subject]
CD103+
Konu Başlıkları
[dc.subject]
CD4/CD8
Konu Başlıkları
[dc.subject]
Sarcoidosis
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1124-0490
İlk Sayfa Sayısı
[dc.identifier.startpage]
305
Son Sayfa Sayısı
[dc.identifier.endpage]
312
Dergi Adı
[dc.relation.journal]
Sarcoidosis Vasculitis and Diffuse Lung Diseases
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
32
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/4840
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
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36
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
19 Şubat 2024 07:01
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Tıklayınız
CD4/CD8 sarcoidosis diseases diffuse parenchimal sensitivity specificity respectively lavage patients and/or biopsy proven clinicoradiological CD8+CD103+ values significantly distinguish Bronchoalveolar diagnosis specific sensitive diagnostic Mattioli CD8+CD103+/CD8+ CD3+16+56+ CD3+103+ whereas findings highly cytometry without appropriate histopathological Conclusion
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