Rectal dexmedetomidine in rats: Evaluation of sedative and mucosal effects [Dexmedetomidina retal em ratos: Avaliação dos efeitos sedativos e sobre a mucosa]

Background and objectives: In this study, we investigated the anesthetic and mucosal effects of the rectal application of dexmedetomidine to rats. Methods: Male Wistar albino rats weighing 250-300g were divided into four groups: Group S (n=8) was a sham group that served as a baseline for the normal basal values; Group C (n=8) consisted of rats that received the rectal application of saline alone; Group IPDex (n=8) included rats that received the intraperitoneal application of dexmedetomidine (100 µg kg-1); and Group RecDex (n=8) included rats that received the rectal application of dexmedetomidine (100 µg kg-1). For the rectal drug administration, we used 22G intravenous cannulas with the stylets removed. We administered the drugs by advancing the cannula 1cm into the rectum, and the rectal administration volume was 1mL for all the rats. The latency and anesthesia time (min) were measured. Two hours after rectal administration, 75 mg kg-1 ketamine was administered for intraperitoneal anesthesia in all the groups, followed by the removal of the rats' rectums to a distal distance of 3cm via an abdominoperineal surgical procedure. We histopathologically examined and scored the rectums. Results: Anesthesia was achieved in all the rats in the Group RecDex following the administration of dexmedetomidine. The onset of anesthesia in the Group RecDex was significantly later and of a shorter duration than in the Group IPDEx (p < 0.05). In the Group RecDex, the administration of dexmedetomidine induced mild-moderate losses of mucosal architecture in the colon and rectum, 2 h after rectal inoculation. Conclusion: Although 100µgkg-1 dexmedetomidine administered rectally to rats achieved a significantly longer duration of anesthesia compared with the rectal administration of saline, our histopathological evaluations showed that the rectal administration of 100µgkg-1 dexmedetomidine led to mild-moderate damage to the mucosal structure of the rectum. © 2013 Sociedade Brasileira de Anestesiologia.

Yazar Hanci V.
Gülle K.
Karakaya K.
Yurtlu S.
Akpolat M.
Yüce M.F.
Yüce F.Z.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/7335
Tek Biçim Adres 10.1016/j.bjan.2013.09.004
Konu Başlıkları Anesthesia
Dexmedetomidine
Mucosa
Rat
Rectum
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
Dergi Adı Revista Brasileira de Anestesiologia
Dergi Cilt Bilgisi 65
Dergi Sayısı 1
Sayfalar 1 - 6
Yayın Yılı 2015
Eser Adı
[dc.title]
Rectal dexmedetomidine in rats: Evaluation of sedative and mucosal effects [Dexmedetomidina retal em ratos: Avaliação dos efeitos sedativos e sobre a mucosa]
Yazar
[dc.contributor.author]
Hanci V.
Yazar
[dc.contributor.author]
Gülle K.
Yazar
[dc.contributor.author]
Karakaya K.
Yazar
[dc.contributor.author]
Yurtlu S.
Yazar
[dc.contributor.author]
Akpolat M.
Yazar
[dc.contributor.author]
Yüce M.F.
Yazar
[dc.contributor.author]
Yüce F.Z.
Yayın Yılı
[dc.date.issued]
2015
Yayıncı
[dc.publisher]
Elsevier Editora Ltda
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background and objectives: In this study, we investigated the anesthetic and mucosal effects of the rectal application of dexmedetomidine to rats. Methods: Male Wistar albino rats weighing 250-300g were divided into four groups: Group S (n=8) was a sham group that served as a baseline for the normal basal values; Group C (n=8) consisted of rats that received the rectal application of saline alone; Group IPDex (n=8) included rats that received the intraperitoneal application of dexmedetomidine (100 µg kg-1); and Group RecDex (n=8) included rats that received the rectal application of dexmedetomidine (100 µg kg-1). For the rectal drug administration, we used 22G intravenous cannulas with the stylets removed. We administered the drugs by advancing the cannula 1cm into the rectum, and the rectal administration volume was 1mL for all the rats. The latency and anesthesia time (min) were measured. Two hours after rectal administration, 75 mg kg-1 ketamine was administered for intraperitoneal anesthesia in all the groups, followed by the removal of the rats' rectums to a distal distance of 3cm via an abdominoperineal surgical procedure. We histopathologically examined and scored the rectums. Results: Anesthesia was achieved in all the rats in the Group RecDex following the administration of dexmedetomidine. The onset of anesthesia in the Group RecDex was significantly later and of a shorter duration than in the Group IPDEx (p < 0.05). In the Group RecDex, the administration of dexmedetomidine induced mild-moderate losses of mucosal architecture in the colon and rectum, 2 h after rectal inoculation. Conclusion: Although 100µgkg-1 dexmedetomidine administered rectally to rats achieved a significantly longer duration of anesthesia compared with the rectal administration of saline, our histopathological evaluations showed that the rectal administration of 100µgkg-1 dexmedetomidine led to mild-moderate damage to the mucosal structure of the rectum. © 2013 Sociedade Brasileira de Anestesiologia.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
por
Konu Başlıkları
[dc.subject]
Anesthesia
Konu Başlıkları
[dc.subject]
Dexmedetomidine
Konu Başlıkları
[dc.subject]
Mucosa
Konu Başlıkları
[dc.subject]
Rat
Konu Başlıkları
[dc.subject]
Rectum
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0034-7094
İlk Sayfa Sayısı
[dc.identifier.startpage]
1
Son Sayfa Sayısı
[dc.identifier.endpage]
6
Dergi Adı
[dc.relation.journal]
Revista Brasileira de Anestesiologia
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
65
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.bjan.2013.09.004
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/7335
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
35
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 08:14
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Tıklayınız
rectal dexmedetomidine administration RecDex application anesthesia rectum administered received mucosal duration rectums saline mild-moderate achieved included intraperitoneal significantly groups 100µgkg-1 scored distance Anestesiologia following Brasileira examined abdominoperineal surgical procedure Anesthesia histopathologically Results evaluations shorter inoculation
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