The role of vitamin D in children with recurrent Tonsillopharyngitis

Background: The exact etiology of recurrent tonsillopharyngitis in children is not clear. Recurrent tonsillitis in children has multifactorial etiology like most of the diseases in childhood. In this study, our aim was to determine the potential role of vitamin D in recurrent tonsillitis by measuring serum 25-OH vitamin D levels and determining the vitamin D receptor polymorphism among children with recurrent tonsillitis. Methods: Eighty-four children with recurrent tonsillitis and seventy-one healthy children aging between 2 and 10 years were enrolled in this study. Serum 25-OH vitamin D level was measured with ELISA and vitamin D receptor gene polymorphism (Apa1, Taq 1, Fok1) was determined by PCR. Serum 25-OH vitamin D level below 50 nmol/L was accepted as deficiency. The vitamin D receptor gene polymorphism in each group was compared. Results: The mean age was 5.6 ± 2.4 and 6.1 ± 2.7 years in study and control group, respectively. The average serum 25-OH vitamin D level was 142.7 ± 68.1 nmol/L in study group and 192.3 ± 56.1 nmol/L in control group. There was significant difference between the groups (p < 0.01). In study group, 4.7% (n = 4) of children had serum 25 OH vitamin D levels below 50 nmol/L. None of the children in control group had serum 25-OH vitamin D level below 50 nmol/L. There was no significant differences in vitamin D receptor gene polymorphisms between groups. Conclusion: Serum 25-OH vitamin D levels in recurrent tonsillitis group were lower than those in healthy children. But, there was no difference in the incidence of vitamin D receptor gene polymorphism between the two groups. © 2012 Yildiz et al.; licensee BioMed Central Ltd.

Yazar Yildiz I.
Unuvar E.
Zeybek U.
Toptas B.
Cacina C.
Toprak S.
Kilic A.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/8263
Tek Biçim Adres 10.1186/1824-7288-38-25
Konu Başlıkları Child
Infection
Tonsillitis
Vitamin D
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı Italian Journal of Pediatrics
Dergi Cilt Bilgisi 38
Dergi Sayısı 1
Sayfalar -
Yayın Yılı 2012
Eser Adı
[dc.title]
The role of vitamin D in children with recurrent Tonsillopharyngitis
Yazar
[dc.contributor.author]
Yildiz I.
Yazar
[dc.contributor.author]
Unuvar E.
Yazar
[dc.contributor.author]
Zeybek U.
Yazar
[dc.contributor.author]
Toptas B.
Yazar
[dc.contributor.author]
Cacina C.
Yazar
[dc.contributor.author]
Toprak S.
Yazar
[dc.contributor.author]
Kilic A.
Yayın Yılı
[dc.date.issued]
2012
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: The exact etiology of recurrent tonsillopharyngitis in children is not clear. Recurrent tonsillitis in children has multifactorial etiology like most of the diseases in childhood. In this study, our aim was to determine the potential role of vitamin D in recurrent tonsillitis by measuring serum 25-OH vitamin D levels and determining the vitamin D receptor polymorphism among children with recurrent tonsillitis. Methods: Eighty-four children with recurrent tonsillitis and seventy-one healthy children aging between 2 and 10 years were enrolled in this study. Serum 25-OH vitamin D level was measured with ELISA and vitamin D receptor gene polymorphism (Apa1, Taq 1, Fok1) was determined by PCR. Serum 25-OH vitamin D level below 50 nmol/L was accepted as deficiency. The vitamin D receptor gene polymorphism in each group was compared. Results: The mean age was 5.6 ± 2.4 and 6.1 ± 2.7 years in study and control group, respectively. The average serum 25-OH vitamin D level was 142.7 ± 68.1 nmol/L in study group and 192.3 ± 56.1 nmol/L in control group. There was significant difference between the groups (p < 0.01). In study group, 4.7% (n = 4) of children had serum 25 OH vitamin D levels below 50 nmol/L. None of the children in control group had serum 25-OH vitamin D level below 50 nmol/L. There was no significant differences in vitamin D receptor gene polymorphisms between groups. Conclusion: Serum 25-OH vitamin D levels in recurrent tonsillitis group were lower than those in healthy children. But, there was no difference in the incidence of vitamin D receptor gene polymorphism between the two groups. © 2012 Yildiz et al.; licensee BioMed Central Ltd.
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Child
Konu Başlıkları
[dc.subject]
Infection
Konu Başlıkları
[dc.subject]
Tonsillitis
Konu Başlıkları
[dc.subject]
Vitamin D
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1720-8424
Dergi Adı
[dc.relation.journal]
Italian Journal of Pediatrics
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
38
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1186/1824-7288-38-25
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/8263
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
19
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
07 Şubat 2024 12:12
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Tıklayınız
vitamin children recurrent receptor tonsillitis nmol/L between polymorphism levels groups control significant difference healthy etiology licensee Yildiz BioMed average Central incidence differences polymorphisms Conclusion Background respectively potential determine childhood diseases determining multifactorial Recurrent tonsillopharyngitis measuring
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